Characterization of Acute Pain

RecruitingObservational study

Characterization of Acute Nociceptive Pain and Analgesic Response in Pediatric and Adolescent Patients

Who can join

Ages 6 to 21 · All sexes

Full eligibility criteria

Inclusion Criteria:

* Children and adolescents ages 6 to 21 years
* Undergoing elective surgical procedures without a history of chronic pain, OR undergoing or planning to undergo bone marrow transplantation (BMT)
* Able to provide written informed assent and parental permission/consent, as applicable

Exclusion Criteria:

* Documented history of eye disease that precludes pupillometry
* Unwilling or unable to participate

About the study

This study aims to better understand how acute pain and responses to pain treatment can be measured in children and adolescents using a non-invasive device. Pain is usually assessed using self-reported or observational scales, which can be difficult to interpret, especially in pediatric patients. This study will evaluate whether a novel device, the AlgometRx Nociometer, can provide an objective measure of nociceptive pain. Participants ages 6 to 21 years who are undergoing elective surgery or bone marrow transplantation will be enrolled at Children's National Hospital. The device measures changes in pupil size in response to gentle electrical stimulation, which reflects activity in pain-related nerve pathways. Measurements will be taken before and after procedures and during routine hospital care, alongside standard pain assessments. This is an observational study. Participation will not change or guide any medical treatment, and all pain management will follow standard clinical care. The information collected may help improve future pain assessment and treatment for pediatric patients.

What is being tested

AlgometRx Nociometer (device)

Sponsor: Children's National Research Institute · Participants: 100 · Started: Dec 2, 2025

Contact the study team

Julia Finkel, M.D · Phone: 202-841-0362
Shaghayegh Rezalou · Phone: 216-463-5052

Official record on ClinicalTrials.gov — NCT07336264

Locations in the U.S.

District of Columbia

Children's National Hospital, Washington D.C.

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.