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Mindfulness Training During Accelerated TMS for Depression

MB-TBS: Mindfulness-Based Theta-Burst Stimulation-A Pilot Study Integrating Mindfulness Training Into Accelerated Neuromodulation Therapy for Depression

Who can join

Ages 18 to 80 · All sexes

Inclusion Criteria:

* Clinical diagnosis of MDD and eligible for aiTBS at MUSC
* Already enrolled in aiTBS course at MUSC
* English proficiency
* Smartphone or willingness to use study-provided device

Exclusion Criteria:

* TMS contraindications (e.g., seizure history, implants, pregnancy)
* Concurrent neuromodulation (ECT, VNS)
* Psychotic disorder, bipolar disorder, active substance use disorder, high suicide risk
* Unable/unwilling to engage in mindfulness or complete questionnaires

About the study

This NIH-funded single-arm pilot tests the feasibility, acceptability, and preliminary effects of embedding brief guided mindfulness practice (via the Waking Up smartphone app) into the inter-session intervals of clinically administered accelerated intermittent theta-burst stimulation (aiTBS) for major depressive disorder (MDD). Participants receive aiTBS as standard clinical care at MUSC; the research intervention is daily guided mindfulness practice during the aiTBS course. Outcomes include feasibility/acceptability, changes in state mindfulness and hedonic tone (Day 0 to Day 5), perceived ease of meditation, trait mindfulness at 4 and 12 weeks, and durability of antidepressant response (PHQ-9) at 4 and 12 weeks.

What is being tested

• Guided Mindfulness Practice using a study created web app that links to the commercially available Waking Up app (behavioral)

Sponsor: Medical University of South Carolina · Participants: 20 · Started: Apr 13, 2026

Contact the study team

Official record on ClinicalTrials.gov — NCT07369557

Locations in the U.S.

Conditions

• Depression
• Major Depressive Disorder

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.