Feasibility and Adherence to a Technology-assisted Home-based Strength Training Program in Adults With Type 2 Diabetes Mellitus and Mild Cognitive Impairment

Inclusion Criteria:

1. Age: 55-80 years
2. Diabetes: Diagnosed T2DM with ≥5 years duration
3. Cognitive Status: Mild cognitive impairment as defined by Petersen criteria and confirmed by Montreal Cognitive Assessment (MoCA) scores of 18-25
4. Medication Stability: Stable medication regimen for at least 3 months
5. Physical Capability: Physically capable of participating in moderate-intensity exercise (physician clearance required)
6. Support System: Having a caregiver or support person willing to assist with technology use if needed

Exclusion Criteria:

1. Diagnosis of movement disorders such as multiple sclerosis, parkinson's disease
2. Diagnosis of Alzheimer's disease,
3. Current diagnosis of severe depression, major psychiatric conditions such as bipolar disorder, psychosis, schizophrenia, or alcoholism that could affect the ability to understand and/or cooperate fully with the protocol.
4. Significant cerebral vascular disease
5. Concomitant medications with significant cholinergic or anticholinergic effects or adverse effects on cognition, including antipsychotics, tricyclic antidepressants, anticonvulsants, sedative/hypnotics, anxiolytics, glucocorticoids (chronic or frequent intermittent),
6. Visual/hearing impairment that would significantly impact the ability to participate in psychometric testing.
7. Significant medical illness or organ failure, including hepatic or renal failure, unstable cardiac disease,
8. Untreated B12 deficiency or hypothyroidism (stable treatment for at least 3 months is allowable).
9. Uncontrolled hypertension: over 160 mmHg systolic or 100 mmHg diastolic (stable treatment is allowable).
10. Stage 5 renal impairment (GFR less than 15 or dialysis).
11. Participation in another clinical trial.
12. Prisoners.
13. Exercise Contraindications: Any condition that would make moderate-intensity exercise unsafe such as a history of severe aortic stenosis, poorly controlled hypertension, angina, or syncope.
14. Lack of Support: No available caregiver or support person for technology assistance