Precision Microbiota Interventions for Senoreduction Trial
RecruitingPhase 1/2
Geroprotective Precision Medicine Strategies in PWH That Use Alcohol
Who can join
Ages 40 and older · All sexes
Full eligibility criteria
Inclusion Criteria: * Age ≥40 years * People with HIV * Recent alcohol use defined as ≥42 grams in the prior week and positive urine ethyl glucuronide (EtG) Exclusion Criteria: * Probiotic use in past 3 months * Recent antibiotics or immunosuppressives * Allergy to study products * Pregnancy or breastfeeding * Inability to comply
About the study
People with HIV who drink alcohol are at increased risk for accelerated aging biology, including increased immune senescence. This randomized, double-blind, crossover clinical trial evaluates two generally recognized as safe (GRAS) microbiota-targeted interventions on immune senescence biomarkers.
What is being tested
- Limosilactobacillus reuteri (dietary supplement)
- Blueberry extract (dietary supplement)
Sponsor: Louisiana State University Health Sciences Center in New Orleans · Participants: 160 · Started: Sep 1, 2026
Contact the study team
- David A Welsh, MD · Phone: United States
Official record on ClinicalTrials.gov — NCT07462767
Locations in the U.S.
| Louisiana | LSU Health, New Orleans |
Conditions
From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.