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Caris Chromoseq Data Collection

An Observational Study to Describe the Performance of Caris Chromoseq as Compared to Conventional Cytogenetics, FISH, and NGS Testing Among Patients Receiving the Caris Chromoseq Assay for Hematologic Malignancies

Who can join

Ages 18 and older · All sexes

Inclusion Criteria:

In order to be eligible to participate in this study, an individual must meet all of the following criteria:

1. Stated willingness to comply with all study procedures and availability for the duration of the study and has signed consent form
2. Subject must be 18 or older
3. Subject be diagnosed with acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), or myeloproliferative neoplasms (MPN)
4. Physician must order or plan to order Caris Chromoseq for their patient
5. Physicians must order or have ordered conventional cytogenetics, FISH, and NGS testing for AML, MDS, or MPN within the same timeframe of Caris Chromoseq without intervening line of therapy.

Exclusion Criteria:

An individual who meets any of the following criteria will be excluded from participation in this study:

1. Patient for whom Caris Chromoseq is not being ordered
2. Patient is pregnant or lactating
3. Patient is not able or willing to provide consent to data collection for this protocol

About the study

The study will collect clinical data on patients who receive the Caris Chromoseq assay for an underlying hematologic malignancy. The assay provides risk stratification for patients with acute myeloid leukemia (AML) myelodysplastic syndrome (MDS), or myeloproliferative neoplasms (MPN). The hypothesis of the study is that Caris Chromoseq compares favorably to conventional cytogenetics, FISH, and NGS analysis in terms of risk stratification capabilities, ease of use, and turnaround time.

What is being tested

• Caris Chromoseq (diagnostic test)

Sponsor: Caris Science, Inc. · Participants: 300 · Started: 2026-07

Contact the study team

• Mary Baker · Phone: 602-571-2771
• Harshita Mittal · Phone: 617-862-1263

Official record on ClinicalTrials.gov — NCT07680868

Locations in the U.S.

Conditions

• Acute Myeloid Leukemia
• Myeloproliferative Neoplasms

From ClinicalTrials.gov, data retrieved Oct 2, 2026. Each study sets its own eligibility; the study team decides who can join.