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VNS Algorithm for Advanced Dosing

VNS Algorithm for Advanced Dosing: Example Guided Mode Titrations "The Augusta Way"

Who can join

Ages 18 to 75 · All sexes

Inclusion Criteria:

* Subjects who are clinically determined to be candidates for VNS implantation for seizure control
* Subject/legally authorized representative able to provide informed consent.

Exclusion Criteria:

* Subjects with VNS system treating pathologies other than drug refractory epilepsy or medical co-morbidities that prevent any surgical intervention

About the study

The goal of this clinical trial is to compare the standard programming of the VNS device (Control) to a modified programming (Augusta Way) in adults with epilepsy. The main question it aims to answer is:

Does the modified programming of the VNS reduce seizures faster than the standard programming?

Participants in both groups will:

1. Attend up to 3 study visits every 3 months for 2 years 2. Answer questionnaires to assess quality of life and cognitive function 3. Maintain a diary of seizure activity

What is being tested

• Rapid Titration VNS programming (device)
• Standard VNS programming (device)

Sponsor: Fernando Vale · Participants: 80 · Started: Aug 1, 2025

Contact the study team

• Brandy Quarles, MPH · Phone: 706-721-0390

Official record on ClinicalTrials.gov — NCT07725601

Locations in the U.S.

Conditions

• Epilepsy
• Drug Resistant Epilepsy

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.