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Liver Cancer clinical trials recruiting in the U.S.
67 studies for Liver Cancer are recruiting participants at sites across the United States.
The most common form of liver cancer in adults is hepatocellular carcinoma. Learn about diagnosis, treatment and taking part in research studies.
Cities with the most studies
- Houston, TX14 studies
- Los Angeles, CA11 studies
- Cleveland, OH11 studies
- Dallas, TX10 studies
- Boston, MA9 studies
- St. Louis, MO8 studies
- Chicago, IL8 studies
- Durham, NC7 studies
- Philadelphia, PA7 studies
- Orange, CA6 studies
- New York City, NY6 studies
- Washington, DC6 studies
- Seattle, WA5 studies
- Nashville, TN5 studies
- Baldwin Park, CA5 studies
- Pittsburgh, PA5 studies
- San Francisco, CA5 studies
- Rochester, MN5 studies
- Aurora, CO4 studies
- San Diego, CA4 studies
- Ann Arbor, MI4 studies
- Mountain View, CA4 studies
- Highlands Ranch, CO3 studies
- Omaha, NE3 studies
- Kansas City, MO3 studies
- Tampa, FL3 studies
- Irvine, CA3 studies
- Santa Monica, CA3 studies
- Birmingham, AL3 studies
- Miami, FL3 studies
- Portland, OR3 studies
- The Bronx, NY3 studies
- Baltimore, MD3 studies
- Atlanta, GA3 studies
- San Antonio, TX3 studies
- Columbus, OH3 studies
- Winston-Salem, NC3 studies
- Richmond, VA3 studies
By state
- Alabama3 studies
- Arizona5 studies
- Arkansas3 studies
- California24 studies
- Colorado7 studies
- Connecticut3 studies
- Florida10 studies
- Georgia4 studies
- Illinois11 studies
- Kansas3 studies
- Maryland8 studies
- Massachusetts11 studies
- Michigan5 studies
- Minnesota9 studies
- Missouri11 studies
- Nebraska3 studies
- New York10 studies
- North Carolina11 studies
- Ohio15 studies
- Oklahoma3 studies
- Oregon3 studies
- Pennsylvania13 studies
- Tennessee6 studies
- Texas24 studies
- Utah3 studies
- Virginia7 studies
- Washington5 studies
- Wisconsin5 studies
Recently updated studies
Symbiotic-GI-13: A Study to Learn About Study Medicine Called PF-08634404 as a Single Treatment and Combination Treatment in Adult Participants With a Liver Cancer Called Hepatocellular Carcinoma, That is Too Advanced to be Removed by Surgery and May Have Spread to Other Parts of the Body.
RecruitingPhase 1/2
Ages 18 and older ยท All sexes ยท Updated Sep 28, 2026 ยท NCT07227012Collection of Blood From Patients With Cancer
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older ยท All sexes ยท Updated Sep 28, 2026 ยท NCT00034216DESTINY-PANTUMOUR04
RecruitingObservational study
Ages 18 to 130 ยท All sexes ยท Updated Sep 25, 2026 ยท NCT07124000National Liver Cancer Screening Trial
RecruitingPhase 4
Ages 18 to 85 ยท All sexes ยท Updated Sep 25, 2026 ยท NCT06084234A Study to Assess Adverse Events and Change in Disease Activity of Intravenously (IV) Infused ABBV-324 in Adult Participants With Hepatocellular Cancer (HCC) or Squamous-Cell Non-Small Cell Lung Cancer (LUSC)
RecruitingPhase 1
Ages 18 and older ยท All sexes ยท Updated Sep 22, 2026 ยท NCT06858813Protoacoustic Imaging For 3D Mapping
RecruitingObservational study
Ages 18 and older ยท All sexes ยท Updated Sep 22, 2026 ยท NCT07832617A Study Evaluating a New Radiation Treatment Workflow (NGDS)
Recruiting
Ages 21 and older ยท All sexes ยท Updated Sep 17, 2026 ยท NCT07824583Histotripsy Plus Chemotherapy vs Chemotherapy Alone for Advanced Colorectal Liver Metastasis
Recruiting
Ages 18 and older ยท All sexes ยท Updated Sep 15, 2026 ยท NCT07044362EQUITY GI: A Prospective Study to Enhance Quality, Inclusivity, and Trial Participation in Black Patients With Gastrointestinal Cancer.
Recruiting
Ages 18 and older ยท All sexes ยท Updated Sep 15, 2026 ยท NCT06263088Defining the Ablative Dose for Y-90 TARE
RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Sep 15, 2026 ยท NCT07586046CREO - Microwave Ablation Feasibility Study
Recruiting
Ages 18 and older ยท All sexes ยท Updated Sep 14, 2026 ยท NCT07817147Real-world Evaluation of the HistoSonics Edison System for Treatment of Liver Tumors Across Multidisciplinary Users (BOOMBOX: Master Study)
RecruitingObservational study
Ages 22 and older ยท All sexes ยท Updated Sep 11, 2026 ยท NCT06486454GPC3-Targeted T-Cell Therapy (ECT204) in Adults With Advanced HCC
RecruitingPhase 1/2
Ages 18 and older ยท All sexes ยท Updated Sep 10, 2026 ยท NCT04864054A Study to Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors
RecruitingPhase 1
Ages 18 and older ยท All sexes ยท Updated Sep 9, 2026 ยท NCT06440005Ovarian-Sparing Adaptive Radiotherapy in Young Adult Women
RecruitingObservational study
Ages 18 to 50 ยท Women ยท Updated Sep 2, 2026 ยท NCT06904365Pre- and Post-operative TEG Indices in Patients With or Without Adenocarcinoma Undergoing Surgical Resection
RecruitingObservational studyHealthy volunteers welcome
Ages 18 to 99 ยท All sexes ยท Updated Aug 24, 2026 ยท NCT05517811HepQuant: Study to Assess the Role of Blood-based Biomarkers and Quantitative MR Imaging for Patients Receiving Radiation Therapy for Liver Cancer
Recruiting
Ages 18 and older ยท All sexes ยท Updated Aug 11, 2026 ยท NCT06899152Interleukin-15 and -21 Armored Glypican-3-specific Chimeric Antigen Receptor Expressed in T Cells for Pediatric Solid Tumors
RecruitingPhase 1
Ages 1 to 21 ยท All sexes ยท Updated Aug 6, 2026 ยท NCT04715191Development and Testing of a Patient-facing Educational Tool About Liver Cancer Prevention
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older ยท All sexes ยท Updated Aug 6, 2026 ยท NCT07010315Distance-Based Exercise to Preserve Function and Prevent Disability
Recruiting
Ages 18 and older ยท All sexes ยท Updated Aug 5, 2026 ยท NCT07059884DRAGON Registry - International Multicenter Registry and Medical Image Bank for Patients With Primarily Unresectable Liver Cancer or Liver Metastases That Underwent Combined Portal and Hepatic Vein Embolization (PVE/HVE) to Increase Future Liver Remnant Before Resection.
RecruitingObservational study
Ages 18 and older ยท All sexes ยท Updated Jul 21, 2026 ยท NCT07717437Jump: MR Simulation For Radiation Therapy Master Protocol
Recruiting
Ages 18 and older ยท All sexes ยท Updated Jul 20, 2026 ยท NCT04545957Repurposing Riluzole for Cancer-Related Cognitive Impairment: A Pilot Trial
RecruitingPhase 2
Ages 18 and older ยท All sexes ยท Updated Jul 14, 2026 ยท NCT06580002Multi-analyte Blood Test Clinical Trial
RecruitingObservational study
Ages 18 and older ยท All sexes ยท Updated Jul 10, 2026 ยท NCT05199259An Exosome-Based Liquid Biopsy for the Differential Diagnosis of Primary Liver Cancer
RecruitingObservational study
Ages 18 and older ยท All sexes ยท Updated Jul 7, 2026 ยท NCT06342414From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.