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State Representation in Early Psychosis 2
Who can join
Ages 15 to 45 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: All participants: * Aged between 15 and 45 years * English proficiency, as determined by staff observation and participant self-report * Estimated IQ at or above 70, as estimated by cognitive assessments * Estimated visual acuity at 20/40, as estimated by the visual acuity test Early Psychosis participants: * Clinical diagnosis of schizophrenia, schizoaffective disorder, schizophreniform disorder, psychosis NOS, bipolar disorder with psychosis, or major depressive disorder with psychosis * Age 35 years or younger, or age 36 to 45 years with onset of psychotic symptoms within the previous 5 years * Achieved clinical stability, defined as outpatient status for at least one month prior to study participation Exclusion Criteria: All participants: * Unable or unwilling to provide informed consent * Unable to demonstrate adequate decisional capacity, in the judgment of the consenting study staff member * Illiterate * Previous clinically significant head injury or prolonged unconsciousness, as determined by the investigators * Meets criteria for severe substance or alcohol use disorder within 3 months of behavioral assessment * Presence of any major medical condition that, in the opinion of the investigators, would impede participation or put the participant at additional risk * Has participated in significant formal cognitive training programs, as determined by the investigators * Meets criteria for clinical risk of suicidal behavior Early Psychosis participants: \- Presence of a major neurological disorder Healthy Control participants: * Meets DSM-5 criteria for psychotic or bipolar disorder * Has a first-degree family history of psychotic or bipolar disorder * Presence of a major neurological disorder
About the study
This observational study will examine behavioral and electroencephalography measures related to state representation in individuals with early psychosis and healthy control participants.
Participants will complete clinical interviews, self-report measures, cognitive assessments, computerized behavioral tasks, and EEG assessments. The study will evaluate performance and computed parameters from the Translational Orientation Pattern Expectancy task and Translational Bandit Task, along with EEG variables related to cognitive control, reward processing, and neural synchrony.
The study aims to better understand heterogeneity in early psychosis and identify neurocognitive and neurophysiologic markers that may inform future precision psychiatry approaches.
Sponsor: University of Minnesota · Participants: 500 · Started: Oct 15, 2025
Contact the study team
- Grace Owens · Phone: (612) 741-2826
Official record on ClinicalTrials.gov — NCT07834203
Locations in the U.S.
| Minnesota | University of Minnesota Ambulatory Research Center, Minneapolis University of Minnesota Department of Psychology, Minneapolis |
Conditions
From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.