Tributyrin for Progressive Supranuclear Palsy (PSP): Virtual Trial

Inclusion Criteria:

* Male or Female, age 45 years and over.
* Diagnosis of PSP-Richardson syndrome (RS) based on Movement Disorder Society (MDS) Criteria, including

  1. Vertical supranuclear gaze palsy.
  2. Repeated unprovoked falls OR tendency to fall on the pull test within 3 years.
* Access to the internet and webcam for virtual visits.
* Presence of a caregiver.

Exclusion Criteria:

* Recent history of significant, uncontrolled GI disease such as Gastroesophageal reflux disease, colorectal cancer.
* Significant metabolic or uncontrolled medical comorbidity.
* Regular use of typical anti-cholinergic drugs.
* Women of child-bearing potential, or who are pregnant and/or nursing.
* Suicidal ideation, as indicated by a response of 2 or 3 on question 9 of the Beck Depression Inventory.
* Any other condition or criterion that, in the opinion of the investigators, would preclude safe and meaningful participation in the study.