🔎 Trials Near Me

Home › Obesity › NCT07881458

A Study of EloraTZP in Adult Participants With Obesity or Overweight and Type 2 Diabetes

RecruitingPhase 3

A Phase 3 Study to Investigate the Efficacy and Safety of LY900043 in Adult Participants With Obesity or Overweight and Type 2 Diabetes

Who can join

Ages 18 and older · All sexes

Full eligibility criteria
Inclusion Criteria:

* Have type 2 diabetes
* Have a stable self-reported body weight (\<5% body weight change) for 90 days prior to screening
* Have a BMI of ≥27 kg/m2 at screening
* Have a history of at least 1 self-reported unsuccessful dietary effort to reduce body weight

Exclusion Criteria:

* Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed \>1 year before screening)
* Have a prior or planned endoscopic procedure and/or device-based therapy for obesity and/or type 2 diabetes (prior device-based therapy acceptable if device removal was more than 6 months prior to screening)
* Have type 1 diabetes
* Have taken any of the following within 90 days prior to screening

  * medications with direct amylin, glucagon-like peptide-1 (GLP-1) or glucagon-dependent insulinotropic polypeptide (GIP) receptor activity, including compounded therapies
  * dipeptidyl peptidase 4 (DPP-4) inhibitors, and
  * insulin
* Have had within 90 days prior to screening:

  * heart attack
  * stroke
  * coronary artery revascularization
  * unstable angina, or
  * hospitalization due to congestive heart failure
* Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure
* Have taken medications or alternative remedies intended for weight loss within 90 days of screening

About the study

The purpose of this study is to investigate the efficacy and safety of eloralintide and tirzepatide coformulation (EloraTZP) compared to tirzepatide for body weight reduction in participants with obesity or overweight and type 2 diabetes.

Participation in the study will last about 2 years.

What is being tested

Sponsor: Eli Lilly and Company · Participants: 1,000 · Started: Oct 16, 2026

Contact the study team

Official record on ClinicalTrials.gov — NCT07881458

Locations in the U.S.

ArizonaTucson Clinical Research Institute, Tucson (Not yet recruiting)
CaliforniaPacific Clinical Studies Inc., Los Alamitos (Not yet recruiting)
Los Angeles Institute for Metabolic Research, Los Angeles
ColoradoUniversity of Colorado Anschutz Medical Campus, Aurora (Not yet recruiting)
FloridaAmerican Research Centers of Florida, Pembroke Pines (Not yet recruiting)
Encore Medical Research - Weston, Weston (Not yet recruiting)
GeorgiaCare Access - Dalton - Clinical Trials Center by Walmart & Care Access, Dalton (Not yet recruiting)
HawaiiPacific Diabetes & Endocrine Center, Honolulu (Not yet recruiting)
IndianaDM Clinical Research - Indianapolis, Indianapolis (Not yet recruiting)
LouisianaCare Access - Eunice, Eunice (Not yet recruiting)
Tandem Clinical Research, Marrero (Not yet recruiting)
MissouriCare Access - St. Louis, St Louis (Not yet recruiting)
New JerseyIMA Clinical Research Warren, Warren Township (Not yet recruiting)
New YorkIMA Clinical Research NYC Midtown, New York (Not yet recruiting)
NYC Research, New York (Not yet recruiting)
TexasIMA Clinical Research Austin, Austin (Not yet recruiting)
Diabetes and Thyroid Center of Ft. Worth, Fort Worth (Not yet recruiting)
Care Access - Houston - Clinical Trials Center by Walmart & Care Access, Houston (Not yet recruiting)
Juno Research, Houston (Not yet recruiting)
ERA Health Research-Texas, Midland (Not yet recruiting)
Texas Valley Clinical Research (TVCR) - Mission, Mission (Not yet recruiting)
IMA Clinical Research San Antonio, San Antonio (Not yet recruiting)
Care Access - Tyler - Clinical Trials Center by Walmart & Care Access, Tyler (Not yet recruiting)
VirginiaWashington Center for Weight Management and Research, Arlington (Not yet recruiting)
WashingtonEastside Research Associates, Redmond (Not yet recruiting)

Conditions

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.