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Rehabilitation Through Virtual Immersion & Integrated Exposure for Mild Traumatic Brain Injury (ReVIVE for mTBI)
Who can join
Ages 18 to 55 · All sexes
Full eligibility criteria
Inclusion criteria: * History of one or more concussions. * Presence of mild-to-moderate PTSD symptoms, defined as a score between 20 and 44 on the Davidson Trauma Scale (DTS), indicating clinically relevant but not severe symptomatology (Davidson et al., 1997). * Prior or ongoing therapy, defined as current or recent (within the last 3 months) engagement in standard care treatments such as psychiatric medication management, and evidence-based psychotherapy targeting mTBI or PTSD symptoms. * Prior U.S military service (any duration and any branch) is required for eligibility. Exclusion criteria: * Age over 55 to reduce confounding effects of age-related neurodegeneration and cognitive decline. * Diagnosis of severe psychiatric disorders (e.g., schizophrenia, bipolar disorder). * Active substance abuse. * Presence of unrelated neurological conditions such as epilepsy, stroke, seizure disorders, or neurodegenerative diseases (e.g., Alzheimer's, Parkinson's). * Significant cognitive impairment, assessed by standardized cognitive screening, which would interfere with the ability to participate fully in VR and therapy sessions. * Physical impairments that would prevent safe engagement in VR and therapy.
About the study
The primary goal of this study is to evaluate the effectiveness of an integrated therapeutic model - combining VR and standard psychotherapy in improving executive function and hyperarousal adults impacted with mTBI. Specifically, the study will: Evaluate PTSD Symptom Reduction - PTSD symptoms, specifically hyperarousal and hypervigilance will be assessed using the Davidson Trauma Scale, which will provide insight into improvements PTSD symptom reduction.
What is being tested
- Virtual Reality (device)
- Standard Psychotherapy (behavioral)
Sponsor: Johns Hopkins University · Participants: 30 · Started: 2026-11
Contact the study team
- Saumik Das · Phone: 703-554-0332
- Durga Roy, MD · Phone: 443-422-3506
Official record on ClinicalTrials.gov — NCT07890337
Locations in the U.S.
| Maryland | Johns Hopkins Bayview Medical Center - Pyschiatry, Baltimore |
Conditions
From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.