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Rehabilitation Through Virtual Immersion & Integrated Exposure for Mild Traumatic Brain Injury (ReVIVE for mTBI)

RecruitingPhase 1

Who can join

Ages 18 to 55 · All sexes

Full eligibility criteria
Inclusion criteria:

* History of one or more concussions.
* Presence of mild-to-moderate PTSD symptoms, defined as a score between 20 and 44 on the Davidson Trauma Scale (DTS), indicating clinically relevant but not severe symptomatology (Davidson et al., 1997).
* Prior or ongoing therapy, defined as current or recent (within the last 3 months) engagement in standard care treatments such as psychiatric medication management, and evidence-based psychotherapy targeting mTBI or PTSD symptoms.
* Prior U.S military service (any duration and any branch) is required for eligibility.

Exclusion criteria:

* Age over 55 to reduce confounding effects of age-related neurodegeneration and cognitive decline.
* Diagnosis of severe psychiatric disorders (e.g., schizophrenia, bipolar disorder).
* Active substance abuse.
* Presence of unrelated neurological conditions such as epilepsy, stroke, seizure disorders, or neurodegenerative diseases (e.g., Alzheimer's, Parkinson's).
* Significant cognitive impairment, assessed by standardized cognitive screening, which would interfere with the ability to participate fully in VR and therapy sessions.
* Physical impairments that would prevent safe engagement in VR and therapy.

About the study

The primary goal of this study is to evaluate the effectiveness of an integrated therapeutic model - combining VR and standard psychotherapy in improving executive function and hyperarousal adults impacted with mTBI. Specifically, the study will: Evaluate PTSD Symptom Reduction - PTSD symptoms, specifically hyperarousal and hypervigilance will be assessed using the Davidson Trauma Scale, which will provide insight into improvements PTSD symptom reduction.

What is being tested

Sponsor: Johns Hopkins University · Participants: 30 · Started: 2026-11

Contact the study team

Official record on ClinicalTrials.gov — NCT07890337

Locations in the U.S.

MarylandJohns Hopkins Bayview Medical Center - Pyschiatry, Baltimore

Conditions

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.