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Cognitive Neurocomputational Task Reliability and Clinical Applications Consortium: Study 3
Cognitive Neurocomputational Task Reliability and Clinical Applications Consortium
Who can join
Ages 18 to 59 · All sexes · Healthy volunteers welcome
Full eligibility criteria
Inclusion Criteria: * Residents of the U.S. * between 18-59 years of age Exclusion Criteria: * Resides outside of U.S. * under 18 or over 59 years of age
About the study
In Study 3, all tasks and models from Aim 1 will be evaluated in a large community sample of online participants recruited through Prolific.
Aim 3 will establish 1) requirements for testing computational algorithms in population-based samples, 2) whether task length is optimal, and 3) whether computational parameters help predict psychopathology (hallucinations and delusions in particular) in the general population, and how these predictors may be impacted by demographic variables, such as race, ethnicity, gender, age and other social determinants of health.
Participant demographics will be matched to the U.S. Census 2023 American Community Survey (ACS) data release (updated as available). MPI MacDonald has successfully recruited large online samples for over a decade.
Specifically, researchers will recruit two samples of n=2,000 to preregister hypotheses and then n=3,000 to independently confirm those hypotheses. Multiple methods will affirm the highest quality human self-report and behavioral data for online samples.
Researchers use Prolific, which is known for high quality research participation, maintaining low levels of bots through strategies such as requiring a photo ID and a waiting period. Second, inclusion criteria will require an approval rating of 90-100% from previous researchers. Participants will complete three sessions, each limited to \~60 min to avoid burnout.
What is being tested
- Motion Perception Task (behavioral)
- Sine Wave Speech Task (behavioral)
- Volatility Task (behavioral)
- Choice Probabilistic Reversal Task (behavioral)
- Kamin Blocking Task (behavioral)
- Minnesota Trust Game (behavioral)
Sponsor: Washington University School of Medicine · Participants: 10,000 · Started: Dec 1, 2026
Contact the study team
- Deanna Barch, PhD · Phone: 314-935-8729
Official record on ClinicalTrials.gov — NCT07900893
Locations in the U.S.
| Minnesota | University of Minnesota, Minneapolis |
| Missouri | Washington University, St Louis |
Conditions
From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.