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Colorectal Cancer clinical trials in Louisville, KY

8 studies for Colorectal Cancer are looking for participants at sites in and around Louisville (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, ERASur Trial

RecruitingPhase 2
  • Baptist Health Louisville, Louisville
  • Baptist Health Floyd, New Albany · 4 mi away
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT05673148

Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer

RecruitingPhase 3
  • UofL Health Brown Cancer Center, Louisville
  • Baptist Health Louisville, Louisville
  • Baptist Health EastPoint, Louisville
  • and 1 more
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07222800

A Study to Evaluate the Safety, Pharmacokinetics, and Anti-Tumor Activity of VVD-133214 as Monotherapy and in Combination in Participants With Advanced Solid Tumors

RecruitingPhase 1
  • Norton Cancer Institute - MDC, Louisville
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06004245

A Study of Tucatinib With Trastuzumab and mFOLFOX6 Versus Standard of Care Treatment in First-line HER2+ Metastatic Colorectal Cancer

RecruitingPhase 3
  • Norton Cancer Institute - Downtown, Louisville
  • Norton Cancer Institute, Downtown, Louisville
  • Norton Hospital, Louisville
  • and 4 more
Ages 18 and older · All sexes · Updated Jul 22, 2026 · NCT05253651

A Study to Investigate ALE.P03 as Monotherapy in Adult Patients With Selected Advanced or Metastatic CLDN1+ Solid Tumors

RecruitingPhase 1/2
  • Norton Cancer Institute - Norton Healthcare Pavilion, Louisville
Ages 18 and older · All sexes · Updated Jul 2, 2026 · NCT07169734

Anastomotic Safety and Surveillance Using Real-time Enhanced Sensing Using xBar

Recruiting
  • University of Louisville Hospital, Louisville
Ages 21 and older · All sexes · Updated Jun 16, 2026 · NCT07337590

cfDNA Assay Prospective Observational Validation for Early Cancer Detection and Minimal Residual Disease

RecruitingObservational studyHealthy volunteers welcome
  • Baptist Floyd, New Albany · 4 mi away
Ages 40 and older · All sexes · Updated Jan 20, 2026 · NCT05366881

About Colorectal Cancer

Colorectal cancer starts in the colon or rectum. It may not cause symptoms at first. Screening tests can help find it early, when treatment is most effective.

More about Colorectal Cancer on MedlinePlus

Colorectal Cancer trials in other cities

Other studies in Louisville

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.