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Colorectal Cancer clinical trials in Philadelphia, PA
44 studies for Colorectal Cancer are looking for participants at sites in and around Philadelphia (within about 30 miles). Open a study to see who can join and how to contact the study team.
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The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
RecruitingPhase 1/2
- Abramson Cancer Center of the University of Pennsylvania, Philadelphia
Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, ERASur Trial
RecruitingPhase 2
- Christiana Care Health System-Concord Health Center, Chadds Ford · 23 mi away
- Christiana Care Health System-Wilmington Hospital, Wilmington · 25 mi away
Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
RecruitingObservational studyHealthy volunteers welcome
- Reading Hospital McGlinn Cancer Institute at Phoenixville, Phoenixville · 22 mi away
Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors
RecruitingPhase 1
- Exelixis Clinical Site #98, Philadelphia
A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy
RecruitingPhase 3
- Thomas Jefferson University, Philadelphia
- Fox Chase Cancer Center, Philadelphia
- Alliance Cancer Specialists at Main Line, Penn Wynne · 6 mi away
A Study of GSK5764227 in Combination With Standard of Care (SoC) or Other Agents in Participants With Advanced Solid Tumors
RecruitingPhase 1
- GSK Investigational Site, Philadelphia
Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors
RecruitingPhase 1
- Research Site, Philadelphia
A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer
RecruitingPhase 3
- Thomas Jefferson University, Philadelphia
- Fox Chase Cancer Center, Philadelphia
Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial
RecruitingPhase 3
- Fox Chase Cancer Center, Philadelphia
A Study of LY4337713 in Participants With FAP-Positive Solid Tumors
RecruitingPhase 1
- University of Pennsylvania, Philadelphia
- Fox Chase Cancer Center, Philadelphia
Study of RAS(ON) Inhibitors in Patients With Gastrointestinal Solid Tumors
RecruitingPhase 1/2
- Hospital of the University of Pennsylvania, Philadelphia
A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer
RecruitingPhase 3
- University of Pennsylvania, Philadelphia
Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal Cancer
RecruitingPhase 3
- Clinical Study Site, Philadelphia
- Clinical Study Site, Philadelphia
- Clinical Study Site, Philadelphia
FT836 With or Without Chemotherapy and/or Monoclonal Antibodies, in Participants With Advanced Solid Tumors
RecruitingPhase 1
- Thomas Jefferson University, Sidney Kimmel Cancer Center, Philadelphia
A Randomized Phase 2 Trial of Fruquintinib and TAS-102 as Compared to Fruquintinib in Patients With Refractory Advanced/Metastatic Colorectal Cancer
RecruitingPhase 2
- Thomas Jefferson University - Sidney Kimmel Comprehensive Cancer Center, Philadelphia
Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors
RecruitingPhase 1/2
- Children's Hospital of Philadelphia, Philadelphia
Collecting Blood and Stool Samples to Detect Colorectal Cancer or Advanced Neoplasia in Lynch Syndrome Patients
RecruitingObservational study
- University of Pennsylvania, Philadelphia
FOG-001 in Locally Advanced or Metastatic Solid Tumors
RecruitingPhase 1/2
- University of Pennsylvania, Perelman School of Medicine, Philadelphia
TCR1188-ABC Cells in KRAS-mutated Cancers
RecruitingPhase 1
- University of Pennsylvania, Philadelphia
A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors
RecruitingPhase 1/2
- University of Pennsylvania / Abramson Cancer Center, Philadelphia
- Thomas Jefferson University, Sidney Kimmel Cancer Center, Clinical Research Organization, Philadelphia
AMG 410 Alone and in Combination With Other Agents in Participants With KRAS Altered Advanced or Metastatic Solid Tumors
RecruitingPhase 1
- Thomas Jefferson University, Philadelphia
A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors
RecruitingPhase 1/2
- University of Pennsylvania, Philadelphia
A Study to Evaluate INCB161734 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation
RecruitingPhase 1
- Jefferson University Hospitals, Philadelphia
A Study to Evaluate the Safety and Efficacy of Two Dose Levels of ONO-4578 With Opdivo®, in Combination With mFOLFOX6 and Bevacizumab Versus Standard of Care in Participants With Non-MSI-H/dMMR, PD-L1 Positive Advanced Colorectal Cancer
RecruitingPhase 2
- Thomas Jefferson University, Sidney Kimmel Cancer Center, Philadelphia
A Study to Assess Adverse Events and Change in Disease Activity in Adult Participants Receiving Intravenously Infused Telisotuzumab Adizutecan Alone or With Standard of Care in Participants With Post Adjuvant Circulating Tumor DNA Positive Colorectal Cancer and No Radiographic Evidence of Disease
RecruitingPhase 2
- Abramson Cancer Center at the University of Pennsylvania /ID# 275407, Philadelphia
A Trial to Evaluate the Safety and Activity of Fruquintinib in Minority Populations With Advanced, Previously Treated Colorectal Cancer
RecruitingPhase 4
- Jefferson Health, Philadelphia
A Phase 1 Dose-escalation Trial of KST-6051 in Participants With Advanced Solid Tumors With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Mutation
RecruitingPhase 1
- Sidney Kimmel Cancer Center, Philadelphia
CT-95 in Advanced Cancers Associated With Mesothelin Expression
RecruitingPhase 1
- University of Pennsylvania, Philadelphia
- Context Investigational Site, Philadelphia
A Study of Fruquintinib Plus FOLFIRI as Second-Line Treatment for Participants With Metastatic Colorectal Cancer (FRUITFUL)
RecruitingPhase 2
- Alliance Cancer Specialists, Wynnewood · 7 mi away
Study of IDE196 in Patients With Solid Tumors Harboring GNAQ/11 Mutations or PRKC Fusions
RecruitingPhase 1/2
- Sidney Kimmel Cancer Center at Thomas Jefferson University, Philadelphia
GUCY2C Prime-Boost Vaccination for Advanced Colorectal and Small Bowel Adenocarcinomas
RecruitingPhase 1
- Sidney Kimmel Cancer Center at Thomas Jefferson University, Philadelphia
A Study to Investigate the Safety and Efficacy of KQB365 as Monotherapy and in Combination in Participants With Advanced Solid Malignancies
RecruitingPhase 1
- Sydney Kimmel Cancer Center, Philadelphia
A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors
RecruitingPhase 1/2
- Univ of Pennsylvania, Abramson Cancer Center, Philadelphia
Evaluating Whether an Educational Website Called Current Together After Cancer (CTAC) Improves Follow-up Care for Colorectal Cancer Survivors
RecruitingPhase 3Healthy volunteers welcome
- Christiana Care Health System-Concord Health Center, Chadds Ford · 23 mi away
- Christiana Care Health System-Wilmington Hospital, Wilmington · 25 mi away
A Study of PARG Inhibitor ETX-19477 in Patients With Advanced Solid Malignancies
RecruitingPhase 1/2
- Thomas Jefferson University, Sidney Kimmel Comprehensive Cancer Center, Philadelphia
A Study Evaluating FMC-376 in Participants With KRAS G12C Mutated Solid Tumors
RecruitingPhase 1/2
- University of Pennsylvania, Philadelphia
Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors
RecruitingPhase 1/2
- University of Pennsylvania, Philadelphia
A Phase 1/2 Study to Evaluate CHM-2101, an Autologous Cadherin 17 Chimeric Antigen Receptor (CAR) T Cell Therapy
RecruitingPhase 1/2
- University of Pennsylvania, Philadelphia
Effect on Body Movement and Mental Skills in Patients Who Received Gadolinium-based Contrast Media for Magnetic Resonance Examination Multiple Times Within 5 Years
RecruitingPhase 4
- Albert Einstein Healthcare Network, Philadelphia
LOTUS-CC: An Observational Research Study to Uncover Subtypes of Cancer Cachexia
RecruitingObservational study
- Christiana Care Health System-Wilmington Hospital, Wilmington · 25 mi away
Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer
RecruitingObservational study
- Christiana Care Health System-Wilmington Hospital, Wilmington · 25 mi away
Collection of Samples USOPTIVAL Study
RecruitingObservational studyHealthy volunteers welcome
- University of Pennsylvania, Philadelphia
Neuroprotective Potential of Cannabidiol (CBD) in Preventing Oxaliplatin (Ox)-Induced Neuropathy
RecruitingEarly phase 1
- Fox Chase Cancer Center, Philadelphia
Performance of SGM-101 for the Delineation of Primary and Recurrent Tumor and Metastases in Patients Undergoing Surgery for Colorectal Cancer
RecruitingPhase 3
- Perelman Center for Advanced Medicine, Philadelphia
About Colorectal Cancer
Colorectal cancer starts in the colon or rectum. It may not cause symptoms at first. Screening tests can help find it early, when treatment is most effective.
More about Colorectal Cancer on MedlinePlus
Colorectal Cancer trials in other cities
- Houston, TX102 studies
- New York City, NY78 studies
- Nashville, TN69 studies
- Boston, MA63 studies
- Los Angeles, CA59 studies
- Arlington, VA52 studies
- St. Louis, MO50 studies
- San Antonio, TX46 studies
- Grand Rapids, MI40 studies
- Baldwin Park, CA37 studies
- Chicago, IL34 studies
- Tampa, FL34 studies
Other studies in Philadelphia
- Cancer (all types)59 studies
- Breast Cancer56 studies
- Non-Small Cell Lung Cancer51 studies
- Metastatic Cancer46 studies
- Prostate Cancer44 studies
- Ovarian Cancer44 studies
- Lung Cancer36 studies
- Acute Myeloid Leukemia34 studies
- Heart Failure31 studies
- Endometrial Cancer28 studies
- Depression26 studies
- Pancreatic Cancer26 studies
From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.