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Head and Neck Squamous Cell Carcinoma clinical trials in Milwaukee, WI

13 studies for Head and Neck Squamous Cell Carcinoma are looking for participants at sites in and around Milwaukee (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

High-dose Prophylactic Gabapentin (HOPE) vs. Placebo to Prevent Opioid Use for Oral Mucositis Pain During Concurrent Chemoradiation for Head and Neck Cancer

RecruitingPhase 3
  • Aurora Cancer Care-Milwaukee, Milwaukee
  • Aurora Saint Luke's Medical Center, Milwaukee
  • Medical College of Wisconsin, Milwaukee
  • and 8 more
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06992427

FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC

RecruitingPhase 2/3
  • Site # 0153, Milwaukee
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06788990

Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors

RecruitingPhase 1
  • Exelixis Clinical Site #33, Milwaukee
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT05176483

Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment

RecruitingPhase 3
  • Aurora Cancer Care-Milwaukee, Milwaukee
  • Aurora Saint Luke's Medical Center, Milwaukee
  • Aurora Sinai Medical Center, Milwaukee
  • and 8 more
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06589804

A Study of NT-175 in Adult Participants With Advanced Malignancies That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation

RecruitingPhase 1
  • Research Site, Milwaukee
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT05877599

BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

RecruitingPhase 2
  • Medical College of Wisconsin, Milwaukee
  • ProHealth Waukesha Memorial Hospital, Waukesha · 17 mi away
  • UW Cancer Center at ProHealth Care, Waukesha · 17 mi away
  • and 1 more
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT05136196

Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma

RecruitingPhase 2
  • Medical College of Wisconsin, Milwaukee
  • Drexel Town Square Health Center, Oak Creek · 11 mi away
  • Froedtert Menomonee Falls Hospital, Menomonee Falls · 14 mi away
Ages 18 to 79 · All sexes · Updated Sep 22, 2026 · NCT04671667

A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations

RecruitingPhase 1/2
  • Froedtert & MCW Cancer Center, Milwaukee
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07109726

Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery

RecruitingPhase 2
  • Aurora Cancer Care-Milwaukee, Milwaukee
  • Aurora Saint Luke's Medical Center, Milwaukee
  • Aurora Sinai Medical Center, Milwaukee
  • and 5 more
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT02734537

Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity Cancer

RecruitingPhase 2/3
  • Medical College of Wisconsin, Milwaukee
  • Drexel Town Square Health Center, Oak Creek · 11 mi away
  • Froedtert and MCW Moorland Reserve Health Center, New Berlin · 11 mi away
  • and 1 more
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT04333537

Testing the Addition of the Drug BMX-001, a Radioprotector, or a Placebo to the Usual Chemoradiation Therapy for Patients With Head and Neck Cancer

RecruitingPhase 2
  • Medical College of Wisconsin, Milwaukee
  • Zablocki Veterans Administration Medical Center, Milwaukee
  • Drexel Town Square Health Center, Oak Creek · 11 mi away
  • and 1 more
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT06532279

Comparing Radiation Plus Cetuximab to Radiation Plus Chemotherapy in People With Head and Neck Cancer Who Cannot Receive Cisplatin

RecruitingPhase 3
  • Medical College of Wisconsin, Milwaukee
  • Drexel Town Square Health Center, Oak Creek · 11 mi away
  • Froedtert and MCW Moorland Reserve Health Center, New Berlin · 11 mi away
  • and 1 more
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT07441681

A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer

RecruitingPhase 1/2
  • Froedtert & the Medical College of Wisconsin, Milwaukee
Ages 18 and older · All sexes · Updated Nov 4, 2025 · NCT05902988

Head and Neck Squamous Cell Carcinoma trials in other cities

Other studies in Milwaukee

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.