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Head and Neck Squamous Cell Carcinoma clinical trials in Houston, TX

47 studies for Head and Neck Squamous Cell Carcinoma are looking for participants at sites in and around Houston (within about 30 miles). Open a study to see who can join and how to contact the study team.

A First in Human Study of ALX2004 With Advanced or Metastatic Selected Solid Tumors

RecruitingPhase 1
  • ALX Center 5, Houston
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT07085091

177Lu-BetaBart in Patients With Relapsed/Refractory, Locally Advanced Inoperable, or Metastatic Solid Tumors

RecruitingPhase 1/2
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT07189871

A Study of NT-175 in Adult Participants With Advanced Malignancies That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation

RecruitingPhase 1
  • Research Site, Houston
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT05877599

A Study of Amivantamab in Addition to Standard of Care Agents (SOC) Compared With SOC Alone in Participants With Recurrent/Metastatic Head and Neck Cancer

RecruitingPhase 3
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07276399

Intratumoral N17350 in Advanced Solid Tumors

RecruitingPhase 1/2
  • The University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07339176

Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors

RecruitingPhase 1
  • Oncology Consultants, P.A., Houston
  • University of Texas M.D. Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT05983432

Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer

RecruitingPhase 1/2
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT05267626

A Phase 1/2 Trial of TER-2013 in Patients With Solid Tumors Harboring AKT/PI3K/PTEN Pathway Alterations

RecruitingPhase 1/2
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07109726

A Phase 1 Study of EPI-326 in EGFR-mutant NSCLC and HNSCC

RecruitingPhase 1
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT07462377

ADCE-T02, a Tissue Factor Targeted Antibody-Drug Conjugate, in Patients With Selected Advanced Solid Tumours

RecruitingPhase 1
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT06597721

A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors

RecruitingPhase 1
  • University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 4, 2026 · NCT06465069

A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors

RecruitingPhase 1
  • University of Texas MD Anderson Cancer Center, Houston
  • The University of Texas, MD Anderson Cancer Center - West Houston, Houston
Ages 18 and older · All sexes · Updated Sep 4, 2026 · NCT07090499

FT836 With or Without Chemotherapy and/or Monoclonal Antibodies, in Participants With Advanced Solid Tumors

RecruitingPhase 1
  • M. D. Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT07216105

A Study to Investigate Safety of AZD6750 in Adult Participants With Select Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2
  • Research Site, Houston
Ages 18 and older · All sexes · Updated Aug 19, 2026 · NCT07115043

A Phase 1 Study of NRM-823 in Participants With Locally Advanced or Metastatic Refractory Solid Tumors

RecruitingPhase 1
  • Normunity Investigational Site, Houston
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT07182149

A Study of BMS-986340 as Monotherapy and as Combination Therapy in Participants With Advanced Solid Tumors

RecruitingPhase 1/2
  • Houston Methodist Hospital, Houston
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT04895709

Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity Cancer

RecruitingPhase 2/3
  • Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center, Houston
  • Michael E DeBakey VA Medical Center, Houston
  • UT MD Anderson Cancer Center, Houston
  • and 1 more
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT04333537

SMP-3124LP in Adults With Advanced Solid Tumors

RecruitingPhase 1/2
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Aug 12, 2026 · NCT06526819

A Study of MGC026 in Participants With Advanced Solid Tumors

RecruitingPhase 1
  • The University of Texas MD Anderson Cancer Center, Houston
  • University of Texas Health Science Center at Houston, Houston
Ages 18 and older · All sexes · Updated Aug 11, 2026 · NCT06242470

3-5 FrAction Stereotactic Body Radiation Therapy for Palliation of Head and Neck Squamous Cell Carcinoma: the FAST Phase II Randomized Trial

RecruitingPhase 2
  • M D Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Aug 10, 2026 · NCT05674396

A Study of Bispecific Antibody MCLA-158 in Patients With Advanced Solid Tumors

RecruitingPhase 1/2
  • Oncology Consultants, Houston
Ages 18 and older · All sexes · Updated Jul 29, 2026 · NCT03526835

A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors

RecruitingPhase 1
  • The University of Texas MD Anderson Cancer Center Investigational Pharmacy Services, Houston
  • The University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Jul 22, 2026 · NCT05208762

FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC

RecruitingPhase 2/3
  • Site#0102, Houston
Ages 18 and older · All sexes · Updated Jul 17, 2026 · NCT06788990

First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors

RecruitingPhase 1/2
  • University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Jul 7, 2026 · NCT05768139

A Study of Sigvotatug Vedotin in Advanced Solid Tumors

RecruitingPhase 1
  • Oncology Consultants, PA, Houston
  • Oncology Consultants, PA., Houston
  • The University of Texas M.D. Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Jul 6, 2026 · NCT04389632

Phase 1/2 Study of ETX-636 in Participants With Advanced Solid Tumors

RecruitingPhase 1/2
  • The University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Jun 23, 2026 · NCT06993844

A Study of IDE034 in Adult Participants With Locally Advanced/Metastatic Solid Tumors Types

RecruitingPhase 1
  • MD Anderson, Houston
  • NEXT Texas LLC - Houston, Houston
Ages 18 and older · All sexes · Updated Jun 18, 2026 · NCT07503808

A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors

RecruitingPhase 1
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Jun 11, 2026 · NCT06789172

Methylnatrexone In Resectable Head and Neck Squamous Cell Carcinoma (MINK). A "Window of Opportunity" Pilot Study.

RecruitingPhase 4
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Jun 10, 2026 · NCT06162377

Study With ABBV-CLS-484 in Participants With Locally Advanced or Metastatic Tumors

RecruitingPhase 1
  • University of Texas MD Anderson Cancer Center /ID# 252004, Houston
Ages 18 and older · All sexes · Updated Jun 4, 2026 · NCT04777994

IACS-6274 With or Without Bevacizumab and Paclitaxel for the Treatment of Advanced Solid Tumors

RecruitingPhase 1
  • M D Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Jun 1, 2026 · NCT05039801

DB-1311 in Combination With BNT327 or DB-1305 in Advanced/Metastatic Solid Tumors

RecruitingPhase 2
  • USA12-0, Houston
Ages 18 and older · All sexes · Updated May 22, 2026 · NCT06953089

Trial of Stereotactic HYpofractionateD RadioAblative (HYDRA) Treatment of Laryngeal Cancer

RecruitingPhase 1
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Apr 15, 2026 · NCT03114462

A Study of Ficlatuzumab in Combination With Cetuximab in Participants With Recurrent or Metastatic (R/M) HPV Negative Head and Neck Squamous Cell Carcinoma

RecruitingPhase 3
  • MD Anderson Cancer Center, Houston
  • Oncology Consultants, Houston
Ages 18 and older · All sexes · Updated Apr 9, 2026 · NCT06064877

A Study of VET3-TGI in Patients With Solid Tumors

RecruitingPhase 1
  • University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Apr 7, 2026 · NCT06444815

A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

RecruitingPhase 1
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Feb 13, 2026 · NCT06778863

Binary Oncolytic Adenovirus in Combination With HER2-Specific Autologous CAR VST, Advanced HER2 Positive Solid Tumors

RecruitingPhase 1
  • Baylor St. Luke's Medical Center, Houston
Ages 18 and older · All sexes · Updated Feb 6, 2026 · NCT03740256

VMD-928 Monotherapy and in Combination With Pembrolizumab to Treat TrkA Overexpression Driven Solid Tumors or Lymphoma

RecruitingPhase 1/2
  • The University of Texas MD Anderson Cancer Center (site 127), Houston
Ages 18 to 80 · All sexes · Updated Dec 11, 2025 · NCT03556228

Multi-Site Trial of Navigation vs Treatment as Usual to Improve Initiation of Timely Adjuvant Therapy

Recruiting
  • Baylor College of Medicine, Houston
Ages 18 and older · All sexes · Updated Dec 11, 2025 · NCT05793151

A Study of MT-4561 in Patients With Various Advanced Solid Tumors

RecruitingPhase 1/2
  • The University of Texas MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Dec 11, 2025 · NCT06943521

A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer

RecruitingPhase 1/2
  • M.D. Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Nov 4, 2025 · NCT05902988

A Study of ASP-1929 Photoimmunotherapy in Combination With Pembrolizumab in First-line Treatment of Locoregional Recurrent Squamous Cell Carcinoma of the Head and Neck With No Distant Metastases

RecruitingPhase 3
  • University of Texas, MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Oct 15, 2025 · NCT06699212

A Study to Evaluate TROP2 ADC LCB84 Single Agent and in Combination With an Anti-PD-1 Ab in Advanced Solid Tumors

RecruitingPhase 1/2
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 24, 2025 · NCT05941507

A Study of NX-1607 in Adults With Advanced Malignancies

RecruitingPhase 1
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Sep 9, 2025 · NCT05107674

Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors

RecruitingPhase 1
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Aug 15, 2025 · NCT04429542

A Study of Evofosfamide in Combination with Zalifrelimab and Balstilimab

RecruitingPhase 1/2
  • MD Anderson Cancer Center, Houston
Ages 18 and older · All sexes · Updated Jan 21, 2025 · NCT06782555

Head and Neck Squamous Cell Carcinoma trials in other cities

Other studies in Houston

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.