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Pancreatic Cancer clinical trials in Orange, CA

15 studies for Pancreatic Cancer are looking for participants at sites in and around Orange (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Testing the Safety and Tolerability of the Anti-cancer Drugs Trastuzumab Deruxtecan and Neratinib for Cancers With Changes in the HER2 Gene

RecruitingPhase 1
  • UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT05372614

A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue

RecruitingPhase 2/3
  • UC Irvine Health, Orange
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06989437

A Study to Evaluate Chemotherapy With or Without INCB161734 in Previously Untreated, KRAS G12D-Mutated Metastatic Pancreatic Ductal Adenocarcinoma

RecruitingPhase 3
  • Investigative Site US049, Orange
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07522073

A Study to Evaluate the Effectiveness and Safety of Setidegrasib, Given With Either mFOLFIRINOX or NALIRIFOX Chemotherapies, in People With Pancreatic Cancer

RecruitingPhase 3
  • UC Irvine Health-Chao Family Comprehensive Cancer Center, Orange
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07409272

Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors

RecruitingPhase 1/2
  • UC IRVINE Health, Orange
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06128551

Testing the Addition of Sunitinib Malate to Lutetium Lu 177 Dotatate (Lutathera) in Pancreatic Neuroendocrine Tumors

RecruitingPhase 1
  • UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT05687123

Testing the Addition of a New Anti-cancer Drug, M3814 (Peposertib), to the Usual Radiotherapy in Patients With Locally Advanced Pancreatic Cancer

RecruitingPhase 1/2
  • UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange
Ages 18 and older · All sexes · Updated Sep 1, 2026 · NCT04172532

Pilot Comparing ctDNA IDV vs. SPV Sample in Pts Undergoing Biopsies for Hepatobiliary and Pancreatic Cancers

Recruiting
  • Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange
Ages 18 and older · All sexes · Updated Aug 31, 2026 · NCT05497531

Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer

RecruitingPhase 3
  • UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange
Ages 18 and older · All sexes · Updated Aug 25, 2026 · NCT06958328

Pancreatic Cancer Early Detection Consortium

RecruitingObservational studyHealthy volunteers welcome
  • UC Irvine Health, Orange
Ages 18 to 90 · All sexes · Updated Jul 22, 2026 · NCT04970056

Repurposing Riluzole for Cancer-Related Cognitive Impairment: A Pilot Trial

RecruitingPhase 2
  • Chao Family Comprehensive Cancer Center, University of California Irvine, Orange
Ages 18 and older · All sexes · Updated Jul 14, 2026 · NCT06580002

Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS

RecruitingPhase 1/2
  • UC Irvine/Chao Family Comprehensive Cancer Center, Orange
Ages 18 and older · All sexes · Updated May 15, 2026 · NCT05379985

PhIbRandomGemcitabine(G)w/or w/Out Pitavastatin(P)MainTx UnresecPancreaticAdenocarcinoma(uPDAC)

RecruitingPhase 1
  • Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange
Ages 18 and older · All sexes · Updated May 4, 2026 · NCT07549958

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Orange
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

64Cu-LNTH-1363S in Patients With Sarcoma or Gastrointestinal Tract Cancer

RecruitingPhase 1/2
  • UC Irvine Health - Chao Family Comprehensive Cancer Center, Orange
Ages 15 and older · All sexes · Updated Aug 12, 2025 · NCT06298916

About Pancreatic Cancer

The pancreas is a gland behind your stomach that produces insulin. Pancreatic cancer is hard to catch early. Find out about risk factors and symptoms.

More about Pancreatic Cancer on MedlinePlus

Pancreatic Cancer trials in other cities

Other studies in Orange

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.