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Drug Use and Addiction clinical trials recruiting in the U.S.
169 studies for Drug Use and Addiction are recruiting participants at sites across the United States.
Drugs include prescription and over-the-counter medicines, alcohol, tobacco, and illegal substances. Repeated drug use can change the brain and lead to addiction.
Cities with the most studies
- Baltimore, MD13 studies
- Houston, TX9 studies
- New York City, NY9 studies
- New Haven, CT8 studies
- Boston, MA7 studies
- Chicago, IL7 studies
- Charleston, SC7 studies
- Los Angeles, CA6 studies
- San Francisco, CA6 studies
- San Diego, CA6 studies
- Providence, RI5 studies
- Eugene, OR5 studies
- Dallas, TX5 studies
- Salt Lake City, UT5 studies
- Indianapolis, IN4 studies
- Minneapolis, MN4 studies
- Atlanta, GA4 studies
- Columbus, OH3 studies
- Seattle, WA3 studies
- Madison, WI3 studies
- St. Louis, MO3 studies
- Aurora, CO3 studies
- Washington, DC3 studies
- Oklahoma City, OK3 studies
- Cambridge, MA3 studies
By state
- Arizona6 studies
- Arkansas3 studies
- California21 studies
- Colorado4 studies
- Connecticut9 studies
- District of Columbia3 studies
- Florida8 studies
- Georgia6 studies
- Illinois8 studies
- Indiana4 studies
- Maryland14 studies
- Massachusetts15 studies
- Michigan6 studies
- Minnesota7 studies
- Missouri3 studies
- Montana3 studies
- New Jersey4 studies
- New York13 studies
- North Carolina4 studies
- Ohio5 studies
- Oklahoma4 studies
- Oregon6 studies
- Pennsylvania7 studies
- Rhode Island5 studies
- South Carolina8 studies
- Texas16 studies
- Utah5 studies
- Washington3 studies
- Wisconsin4 studies
Recently updated studies
Smoking Cessation CM for Veterans With or at Risk for Cancer
RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06432985SMART-r: Substance Monitoring and Active Relapse Tracking Repository
RecruitingObservational study
Ages 18 to 120 · All sexes · Updated Oct 2, 2026 · NCT06676059Outcome Inference in the Sensory Preconditioning Task in Opioid-Use Disorder
RecruitingObservational studyHealthy volunteers welcome
Ages 21 to 60 · All sexes · Updated Oct 2, 2026 · NCT03745339Advanced Functional and Structural MRI Techniques for Neuropharmacological Imaging
RecruitingHealthy volunteers welcome
Ages 18 to 80 · All sexes · Updated Oct 2, 2026 · NCT01036581Wakaya: Rising Up for Choctaw Youth Health
RecruitingHealthy volunteers welcome
Ages 12 to 19 · All sexes · Updated Sep 30, 2026 · NCT05818384Teen Health Choices & Wellness
RecruitingHealthy volunteers welcome
Ages 13 to 16 · All sexes · Updated Sep 29, 2026 · NCT06822569Shared Decision Making to Treat Or Prevent (STOP) HIV in Criminal Legal Involved Populations (R33)
Recruiting
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT07223398Successful Transitions and Reintegration Tools for Veterans (START-VETS)
RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT04366531DEVELOPMENT OF A NOVEL PEER RECOVERY SUPPORTER TRAINING PLATFORM
Recruiting
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT07044531Evaluation of the Safety and Effects of Psychoactive Substances in People With Past Opioid Use
RecruitingPhase 1Healthy volunteers welcome
Ages 18 to 55 · All sexes · Updated Sep 28, 2026 · NCT07218549tAN for Substance Use Disorder
Recruiting
Ages 18 to 64 · All sexes · Updated Sep 28, 2026 · NCT07281261rTMS for Craving in Methamphetamine Use Disorder
Recruiting
Ages 18 to 65 · All sexes · Updated Sep 23, 2026 · NCT03470480A SMART Evaluation of an Adaptive Web-based AUD Treatment for Service Members and Their Partners
RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT05619185Safe & Sound Protocol in Adults With Trauma and SUD
Recruiting
Ages 18 to 75 · All sexes · Updated Sep 21, 2026 · NCT07219056Clinical Decision Support to Increase Use of Medications for Opioid Use Disorder
RecruitingObservational studyHealthy volunteers welcome
Ages 12 to 89 · All sexes · Updated Sep 21, 2026 · NCT06526286Couples Motivational Interviewing to Reduce Drug Use and HIV Risk in Vulnerable Male Couples
RecruitingHealthy volunteers welcome
Ages 18 to 55 · Men · Updated Sep 17, 2026 · NCT06307977Recovery Inspired Support Engagement (RISE) Pilot
RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT07519759Real-time Opioid Study
Recruiting
Ages 18 to 50 · All sexes · Updated Sep 14, 2026 · NCT07768007Defining Neurobiological Links Between Substance Use and Mental Illness
RecruitingHealthy volunteers welcome
Ages 18 to 60 · All sexes · Updated Sep 11, 2026 · NCT05538910Efficacy of a Multi-level School Intervention for LGBTQ Youth
RecruitingHealthy volunteers welcome
Ages 12 to 20 · All sexes · Updated Sep 11, 2026 · NCT05541406Temporal Interference Methods for Addiction Treatment
RecruitingHealthy volunteers welcome
Ages 21 to 50 · All sexes · Updated Sep 11, 2026 · NCT07210268Ultrasound Neuromodulation of the Brain for Alcohol Use Disorder
Recruiting
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT06518785Project SHIELD 2.0: Police Education to Support Public Health in Kentucky
RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT07804121Orexin s Role in the Neurobiology of Substance Use Disorder
RecruitingHealthy volunteers welcome
Ages 18 to 60 · All sexes · Updated Sep 11, 2026 · NCT05630781Building Social and Structural Connections for the Prevention of Opioid Use Disorder Among Youth Experiencing Homelessness
Recruiting
Ages 14 to 24 · All sexes · Updated Sep 10, 2026 · NCT06311838From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.