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Metastatic Cancer clinical trials in Miami, FL

24 studies for Metastatic Cancer are looking for participants at sites in and around Miami (within about 30 miles). Open a study to see who can join and how to contact the study team.

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Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

RecruitingPhase 2
  • University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami
  • UM Sylvester Comprehensive Cancer Center at Kendall, Miami
All ages · All sexes · Updated Oct 2, 2026 · NCT05564377

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

RecruitingPhase 1/2
  • University of Miami - Sylvester Comprehensive Cancer Center, Miami
Ages 12 and older · All sexes · Updated Oct 2, 2026 · NCT04585750

Atebimetinib + GnP as a First Line Treatment in Patients With Metastatic Pancreatic Adenocarcinoma

RecruitingPhase 3
  • Miami Cancer Institute, Miami
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT07562152

ASPEN-09-03: A Study of Evorpacept in Combination With Trastuzumab and Chemotherapy in Metastatic HER2-Positive Breast Cancer

RecruitingPhase 2
  • Sylvester Comprehensive Cancer Center, Miami
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07007559

A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

RecruitingPhase 3
  • University of Miami Hospital and Clinics, Sylvester Cancer Center, Miami
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07174336

A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer

RecruitingPhase 3
  • University of Miami Hospital and Clinics, Sylvester Cancer Center, Miami
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07213804

Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer

RecruitingPhase 1/2
  • Sylvester Comprehensive Cancer Center - Miami, Miami
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT05267626

Testing the Combination of DS-8201a and Olaparib in HER2-Expressing Cancers With Expansion in Patients With Platinum Resistant Ovarian Cancer

RecruitingPhase 1
  • University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami
  • UM Sylvester Comprehensive Cancer Center at Kendall, Miami
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT04585958

A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

RecruitingPhase 3
  • Miami Cancer Institute at Baptist Health, Inc., Miami
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT06119581

A Study of LY4050784 in Participants With Advanced or Metastatic Solid Tumors

RecruitingPhase 1
  • University of Miami, Miami
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT06561685

Study of the Bria-IMT Regimen and CPI vs Physicians' Choice in Advanced Metastatic Breast Cancer.

RecruitingPhase 3
  • University Of Miami-SCCC-Miami, Miami
  • University of Miami_SCCC - Kendall, Miami
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT06072612

Puxitatug Samrotecan (AZD8205) Monotherapy vs Chemotherapy in B7-H4-selected Endometrial Cancer (Bluestar-Endometrial01)

RecruitingPhase 3
  • Research Site, Miami
  • Research Site, Miami
Ages 18 and older · Women · Updated Jul 29, 2026 · NCT07044336

A Clinical Study of KTX-2001 in Subjects With Metastatic Castration-Resistant Prostate Cancer (STRIKE-001)

RecruitingPhase 1
  • Sylvester Comprehensive Cancer Center, Miami
Ages 18 and older · Men · Updated Jul 9, 2026 · NCT07103018

(Peak) A Phase 3 Randomized Trial of CGT9486+Sunitinib vs. Sunitinib in Subjects With Gastrointestinal Stromal Tumors

RecruitingPhase 3
  • University of Miami - Sylvester Comprehensive Cancer Center, Miami
Ages 18 and older · All sexes · Updated Jun 16, 2026 · NCT05208047

A Study of Neladalkib (NVL-655) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ALK Rearrangement or Activating ALK Mutation (ALKOVE-1)

RecruitingPhase 1/2
  • University of Miami; Sylvester Cancer Center, Miami
Ages 12 and older · All sexes · Updated May 27, 2026 · NCT05384626

Placebo-Controlled Trial of IFx-Hu2.0 Followed By Pembrolizumab In Checkpoint Inhibitor Naïve Participants With Advanced Or Metastatic Merkel Cell Carcinoma

RecruitingPhase 2/3
  • Sylvester Comprehensive Cancer Center, Miami
Ages 18 and older · All sexes · Updated Apr 17, 2026 · NCT06947928

A Study of NVL-330 in Patients With Advanced or Metastatic HER2-altered NSCLC (HEROEX-1)

RecruitingPhase 1
  • Sylvester Comprehensive Cancer Center, Miami
Ages 18 and older · All sexes · Updated Feb 25, 2026 · NCT06521554

A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

RecruitingPhase 1
  • University of Miami - Sylvester Comprehensive Cancer Center, Miami
Ages 18 and older · All sexes · Updated Feb 13, 2026 · NCT06778863

Ivosidenib in Participants With Locally Advanced or Metastatic Conventional Chondrosarcoma Untreated or Previously Treated With 1 Systemic Treatment Regimen

RecruitingPhase 3
  • University of Miami, Miami
Ages 18 and older · All sexes · Updated Feb 6, 2026 · NCT06127407

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Miami
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

A Study to Provide Continued Access to and Assess Long-Term Safety of the Study Drug(s)

RecruitingPhase 3
  • Miami Cancer Institute, Miami
Ages 18 and older · All sexes · Updated Oct 15, 2025 · NCT06174987

A First-in-human (FIH), Phase I Study of PTX-912 in Patients with Locally Advanced/Metastatic Solid Tumors

RecruitingPhase 1
  • University of Miami, Miami
Ages 18 and older · All sexes · Updated Nov 7, 2024 · NCT06190886

Metastatic Cancer trials in other cities

Other studies in Miami

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.