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Amyotrophic Lateral Sclerosis clinical trials in California

23 studies for Amyotrophic Lateral Sclerosis are looking for participants at sites in California.

Cities in California

A Study to Investigate the Safety and Pharmacodynamics of a Single Intrathecal Injection (IT) of INS1202 in Participants With Amyotrophic Lateral Sclerosis (ALS)

  • USA004, La Jolla
  • USA002, Palo Alto
RecruitingPhase 1
Ages 18 to 79 · All sexes · Updated Sep 23, 2026 · NCT07290062

Pridopidine Phase 3 Study to Evaluate Efficacy and Safety in ALS

  • California Pacific Medical Center, San Francisco
RecruitingPhase 3
Ages 18 to 80 · All sexes · Updated Sep 22, 2026 · NCT07322003

RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses

  • Kadima Neuropsychiatry Institute, San Diego
  • Providence Medical Foundation, Santa Rosa
RecruitingPhase 2
Ages 18 to 80 · All sexes · Updated Sep 15, 2026 · NCT07002034

Study is to Assess the Safety and Tolerability of VTx-002 in Participants With ALS

  • University of California San Diego Medical Center, San Diego
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT07287397

Usnoflast Neuromuscular Investigation for Treatment Efficacy in Amyotrophic Lateral Sclerosis

  • Zydus US015, La Jolla
  • Zydus US008, Orange
  • Zydus US013, San Francisco
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 1, 2026 · NCT07023835

ASSESS ALL ALS Study

  • University of California, Irvine, Irvine
  • University of California San Diego, La Jolla
  • University of California, Los Angeles, Los Angeles
  • and 1 more
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Aug 24, 2026 · NCT06578195

PREVENT ALL ALS Study

  • University of California San Diego, La Jolla
  • University of California Irvine, Orange
  • University of California, San Francisco, San Francisco
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Aug 24, 2026 · NCT06581861

Study of COYA 302 for the Treatment of ALS

  • Cedars-Sinai Medical Center, Los Angeles
  • California Pacific Medical Center, San Francisco
RecruitingPhase 2/3
Ages 18 to 80 · All sexes · Updated Aug 6, 2026 · NCT07161999

ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

  • University of California, Los Angeles, Los Angeles
  • University of California, San Diego, San Diego
  • University of California San Francisco, San Francisco
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Jul 30, 2026 · NCT04363684

PHENOGENE-1A (Cromolyn) Treatment in Patients With Mild to Moderate ALS

  • University of California San Diego, La Jolla
  • Sutter Health - California Pacific Medical Center Research Institute, San Francisco
RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Jul 23, 2026 · NCT07142291

Clinical Procedures to Support Research in ALS

  • University of California, Irvine, Irvine
  • Stanford University, Palo Alto
  • California Pacific Medical Center, San Francisco
RecruitingObservational study
Ages 18 and older · All sexes · Updated Jun 15, 2026 · NCT03489278

A Study of Ranolazine in ALS

  • University of California, San Francisco, San Francisco
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jun 8, 2026 · NCT06527222

Biomarkers in Different Types of Amyotrophic Lateral Sclerosis (ALS) Patients Being Treated With Edaravone

  • Loma Linda University, Loma Linda
RecruitingObservational study
Ages 18 to 85 · All sexes · Updated Jun 5, 2026 · NCT04097158

Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia

  • Stanford University School of Medicine, Stanford
Recruiting
Ages 18 to 80 · All sexes · Updated Jun 2, 2026 · NCT05724173

BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia

  • University of California, Davis, Sacramento
  • Stanford University School of Medicine, Stanford
Recruiting
Ages 18 to 80 · All sexes · Updated Jun 1, 2026 · NCT00912041

ALS/MND Natural History Study Data Repository

  • Loma Linda University Health, Loma Linda
  • Kaiser Permanente, Los Angeles
RecruitingObservational study
Ages 18 to 90 · All sexes · Updated May 20, 2026 · NCT05966038

Connect-One: Early Feasibility Study of Connexus® Brain-Computer Interface (BCI)

  • University of California, Davis, Sacramento
Recruiting
Ages 22 to 75 · All sexes · Updated Apr 14, 2026 · NCT07357428

AMX0114 in Adult Participants With Amyotrophic Lateral Sclerosis

  • University of California, San Diego, La Jolla
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Apr 14, 2026 · NCT06665165

Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Speech-02)

  • University of California, Davis, Sacramento
Recruiting
Ages 18 to 80 · All sexes · Updated Dec 1, 2025 · NCT06094205

Target ALS Biomarker Study; Longitudinal Biofluids, Clinical Measures, and At Home Measures

  • University of California San Diego, San Diego
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Nov 21, 2025 · NCT05137665

Efficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS Patients

  • University of Southern California, Los Angeles
RecruitingPhase 3
Ages 18 to 81 · All sexes · Updated Sep 12, 2025 · NCT03127267

Safety, PK and Biodistribution of 18F-OP-801 in Patients With ALS, AD, MS, PD and Healthy Volunteers

  • UCSF, San Francisco
  • Stanford University, Stanford
RecruitingPhase 1/2Healthy volunteers welcome
Ages 18 to 80 · All sexes · Updated May 2, 2025 · NCT05395624

Augmented Reality BCI Longitudinal Study for Persons With Late Stage ALS

  • Cognixion, Santa Barbara
Recruiting
Ages 18 and older · All sexes · Updated Feb 5, 2025 · NCT06810219

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.