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Amyotrophic Lateral Sclerosis clinical trials in California

22 studies for Amyotrophic Lateral Sclerosis are looking for participants at sites in California.

Cities in California

Study is to Assess the Safety and Tolerability of VTx-002 in Participants With ALS

  • University of California San Diego Medical Center, San Diego
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Nov 13, 2026 · NCT07287397

RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses

  • Kadima Neuropsychiatry Institute, San Diego
RecruitingPhase 2
Ages 18 to 80 · All sexes · Updated Nov 10, 2026 · NCT07002034

A Study to Investigate the Safety and Pharmacodynamics of a Single Intrathecal Injection (IT) of INS1202 in Participants With Amyotrophic Lateral Sclerosis (ALS)

  • USA004, La Jolla
  • USA002, Palo Alto
RecruitingPhase 1
Ages 18 to 79 · All sexes · Updated Nov 10, 2026 · NCT07290062

ASSESS ALL ALS Study

  • University of California, Irvine, Irvine
  • University of California San Diego, La Jolla
  • University of California, Los Angeles, Los Angeles
  • and 1 more
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT06578195

Pridopidine Phase 3 Study to Evaluate Efficacy and Safety in ALS

  • California Pacific Medical Center, San Francisco
RecruitingPhase 3
Ages 18 to 80 · All sexes · Updated Oct 27, 2026 · NCT07322003

Brain-Computer Interface Communication Device for People With ALS

  • Cognixion Corporation, Santa Barbara
Recruiting
Ages 18 and older · All sexes · Updated Oct 16, 2026 · NCT07871071

ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

  • University of California, Los Angeles, Los Angeles
  • University of California, San Diego, San Diego
  • University of California San Francisco, San Francisco
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Oct 7, 2026 · NCT04363684

Usnoflast Neuromuscular Investigation for Treatment Efficacy in Amyotrophic Lateral Sclerosis

  • Zydus US015, La Jolla
  • Zydus US008, Orange
  • Zydus US013, San Francisco
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 1, 2026 · NCT07023835

PHENOGENE-1A (Cromolyn) Treatment in Patients With Mild to Moderate ALS

  • University of California San Diego, La Jolla
  • Sutter Health - California Pacific Medical Center Research Institute, San Francisco
RecruitingPhase 2
Ages 18 to 75 · All sexes · Updated Jul 23, 2026 · NCT07142291

Clinical Procedures to Support Research in ALS

  • University of California, Irvine, Irvine
  • Stanford University, Palo Alto
  • California Pacific Medical Center, San Francisco
RecruitingObservational study
Ages 18 and older · All sexes · Updated Jun 15, 2026 · NCT03489278

A Study of Ranolazine in ALS

  • University of California, San Francisco, San Francisco
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jun 8, 2026 · NCT06527222

Biomarkers in Different Types of Amyotrophic Lateral Sclerosis (ALS) Patients Being Treated With Edaravone

  • Loma Linda University, Loma Linda
RecruitingObservational study
Ages 18 to 85 · All sexes · Updated Jun 5, 2026 · NCT04097158

Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia

  • Stanford University School of Medicine, Stanford
Recruiting
Ages 18 to 80 · All sexes · Updated Jun 2, 2026 · NCT05724173

BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia

  • University of California, Davis, Sacramento
  • Stanford University School of Medicine, Stanford
Recruiting
Ages 18 to 80 · All sexes · Updated Jun 1, 2026 · NCT00912041

ALS/MND Natural History Study Data Repository

  • Loma Linda University Health, Loma Linda
  • Kaiser Permanente, Los Angeles
RecruitingObservational study
Ages 18 to 90 · All sexes · Updated May 20, 2026 · NCT05966038

Connect-One: Early Feasibility Study of Connexus® Brain-Computer Interface (BCI)

  • University of California, Davis, Sacramento
Recruiting
Ages 22 to 75 · All sexes · Updated Apr 14, 2026 · NCT07357428

AMX0114 in Adult Participants With Amyotrophic Lateral Sclerosis

  • University of California, San Diego, La Jolla
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Apr 14, 2026 · NCT06665165

Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Speech-02)

  • University of California, Davis, Sacramento
Recruiting
Ages 18 to 80 · All sexes · Updated Dec 1, 2025 · NCT06094205

Target ALS Biomarker Study; Longitudinal Biofluids, Clinical Measures, and At Home Measures

  • University of California San Diego, San Diego
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Nov 21, 2025 · NCT05137665

Efficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS Patients

  • University of Southern California, Los Angeles
RecruitingPhase 3
Ages 18 to 81 · All sexes · Updated Sep 12, 2025 · NCT03127267

Safety, PK and Biodistribution of 18F-OP-801 in Patients With ALS, AD, MS, PD and Healthy Volunteers

  • UCSF, San Francisco
  • Stanford University, Stanford
RecruitingPhase 1/2Healthy volunteers welcome
Ages 18 to 80 · All sexes · Updated May 2, 2025 · NCT05395624

Augmented Reality BCI Longitudinal Study for Persons With Late Stage ALS

  • Cognixion, Santa Barbara
Recruiting
Ages 18 and older · All sexes · Updated Feb 5, 2025 · NCT06810219

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.