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Amyotrophic Lateral Sclerosis clinical trials recruiting in the U.S.
71 studies for Amyotrophic Lateral Sclerosis are recruiting participants at sites across the United States.
Amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, is a nerve disease that weakens muscles and gets worse over time. Learn how to manage symptoms.
Cities with the most studies
- Boston, MA19 studies
- Jacksonville, FL12 studies
- Philadelphia, PA12 studies
- Baltimore, MD11 studies
- San Diego, CA9 studies
- Chicago, IL9 studies
- San Francisco, CA8 studies
- New York City, NY8 studies
- St. Louis, MO8 studies
- Atlanta, GA7 studies
- Phoenix, AZ7 studies
- Houston, TX7 studies
- Miami, FL6 studies
- Washington, DC6 studies
- Minneapolis, MN6 studies
- Durham, NC6 studies
- Seattle, WA6 studies
- Dallas, TX5 studies
- Ann Arbor, MI5 studies
- Mountain View, CA5 studies
- Davie, FL4 studies
- Birmingham, AL4 studies
- Los Angeles, CA4 studies
- State College, PA3 studies
- Scottsdale, AZ3 studies
- Columbus, OH3 studies
- Sacramento, CA3 studies
- Pittsburgh, PA3 studies
- Harrisburg, PA3 studies
- Tampa, FL3 studies
- Detroit, MI3 studies
- Richmond, VA3 studies
- Winston-Salem, NC3 studies
- Portland, OR3 studies
- Aurora, CO3 studies
- Gainesville, FL3 studies
By state
- Alabama4 studies
- Arizona11 studies
- California22 studies
- Colorado4 studies
- Connecticut3 studies
- District of Columbia3 studies
- Florida27 studies
- Georgia7 studies
- Illinois10 studies
- Kansas4 studies
- Maryland14 studies
- Massachusetts23 studies
- Michigan7 studies
- Minnesota8 studies
- Missouri10 studies
- Nebraska4 studies
- New Hampshire3 studies
- New York9 studies
- North Carolina8 studies
- Ohio5 studies
- Oregon3 studies
- Pennsylvania17 studies
- Tennessee4 studies
- Texas13 studies
- Utah4 studies
- Virginia5 studies
- Washington6 studies
Recently updated studies
Study is to Assess the Safety and Tolerability of VTx-002 in Participants With ALS
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Nov 13, 2026 · NCT07287397Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
RecruitingObservational study
Ages 18 to 110 · All sexes · Updated Nov 12, 2026 · NCT03225144Imaging Biomarkers in ALS
RecruitingObservational studyHealthy volunteers welcome
Ages 21 to 75 · All sexes · Updated Nov 12, 2026 · NCT02567136A Study to Learn About the Safety of BIIB147 and Its Effects in Adults With Amyotrophic Lateral Sclerosis (ALS)
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT07855211Healey ALS MyMatch Common Screening Protocol
RecruitingObservational study
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT07400393An Early Feasibility Study of a Robotically Implanted Brain-Computer Interface for Neural Control of External Devices in Spinal Cord Injury, Amyotrophic Lateral Sclerosis, and Chronic Ischemic Stroke
Recruiting
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT07929792RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses
RecruitingPhase 2
Ages 18 to 80 · All sexes · Updated Nov 10, 2026 · NCT07002034VOICE: An Early Feasibility Study of a Precise Robotically Implanted Brain-Computer Interface for Communication Restoration
Recruiting
Ages 22 to 75 · All sexes · Updated Nov 10, 2026 · NCT07224256A Study to Investigate the Safety and Pharmacodynamics of a Single Intrathecal Injection (IT) of INS1202 in Participants With Amyotrophic Lateral Sclerosis (ALS)
RecruitingPhase 1
Ages 18 to 79 · All sexes · Updated Nov 10, 2026 · NCT07290062Clinical Outcome Assessment for AT & BCI
RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Nov 6, 2026 · NCT07407725ASSESS ALL ALS Study
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT06578195MindEx: A Novel, Multifocal, Cognitive Brain-Machine Interface System
Recruiting
Ages 18 to 65 · All sexes · Updated Oct 30, 2026 · NCT05936619Imaging Assessment of Swallowing and Speech Muscles in Inclusion Body Myositis
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Oct 28, 2026 · NCT07823101Pridopidine Phase 3 Study to Evaluate Efficacy and Safety in ALS
RecruitingPhase 3
Ages 18 to 80 · All sexes · Updated Oct 27, 2026 · NCT07322003Brain-Computer Interface Communication Device for People With ALS
Recruiting
Ages 18 and older · All sexes · Updated Oct 16, 2026 · NCT07871071Interfacing With NeuroTechnology to Expand Neural Throughput (INTENT)
Recruiting
Ages 18 to 80 · All sexes · Updated Oct 9, 2026 · NCT07521930Do Video Recordings of Multidisciplinary Clinics Improve Quality of Life for People With ALS and Their Caregivers?
Recruiting
Ages 18 and older · All sexes · Updated Oct 8, 2026 · NCT07454733ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Oct 7, 2026 · NCT04363684Acamprosate in C9orf72 Hexanucleotide Repeat Expansion Amyotrophic Lateral Sclerosis (ACALS)
RecruitingPhase 1
Ages 18 to 99 · All sexes · Updated Oct 1, 2026 · NCT07204977RAPA-501 Therapy for ALS
RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT04220190Developing New Ways to Detect Respiratory Impairment Early in ALS
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07844590Using Gaze to Enable Head-neck Movements in Patients With Head Drop
Recruiting
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07836751Controlling Amyotrophic Lateral Sclerosis Motor Neuron Excitability Study
Recruiting
Ages 18 to 80 · All sexes · Updated Sep 10, 2026 · NCT06649955Effect of Terazosin on ATP Levels in People With Amyotrophic Lateral Sclerosis
RecruitingEarly phase 1
Ages 18 to 80 · All sexes · Updated Sep 9, 2026 · NCT07224269Usnoflast Neuromuscular Investigation for Treatment Efficacy in Amyotrophic Lateral Sclerosis
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 1, 2026 · NCT07023835From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.