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Amyotrophic Lateral Sclerosis clinical trials recruiting in the U.S.

71 studies for Amyotrophic Lateral Sclerosis are recruiting participants at sites across the United States.

Amyotrophic lateral sclerosis (ALS), or Lou Gehrig's disease, is a nerve disease that weakens muscles and gets worse over time. Learn how to manage symptoms.

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Recently updated studies

Study is to Assess the Safety and Tolerability of VTx-002 in Participants With ALS

RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Nov 13, 2026 · NCT07287397

Investigating Complex Neurodegenerative Disorders Related to Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

RecruitingObservational study
Ages 18 to 110 · All sexes · Updated Nov 12, 2026 · NCT03225144

Imaging Biomarkers in ALS

RecruitingObservational studyHealthy volunteers welcome
Ages 21 to 75 · All sexes · Updated Nov 12, 2026 · NCT02567136

A Study to Learn About the Safety of BIIB147 and Its Effects in Adults With Amyotrophic Lateral Sclerosis (ALS)

RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT07855211

Healey ALS MyMatch Common Screening Protocol

RecruitingObservational study
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT07400393

RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses

RecruitingPhase 2
Ages 18 to 80 · All sexes · Updated Nov 10, 2026 · NCT07002034

Clinical Outcome Assessment for AT & BCI

RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Nov 6, 2026 · NCT07407725

ASSESS ALL ALS Study

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT06578195

MindEx: A Novel, Multifocal, Cognitive Brain-Machine Interface System

Recruiting
Ages 18 to 65 · All sexes · Updated Oct 30, 2026 · NCT05936619

Imaging Assessment of Swallowing and Speech Muscles in Inclusion Body Myositis

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Oct 28, 2026 · NCT07823101

Pridopidine Phase 3 Study to Evaluate Efficacy and Safety in ALS

RecruitingPhase 3
Ages 18 to 80 · All sexes · Updated Oct 27, 2026 · NCT07322003

Brain-Computer Interface Communication Device for People With ALS

Recruiting
Ages 18 and older · All sexes · Updated Oct 16, 2026 · NCT07871071

Interfacing With NeuroTechnology to Expand Neural Throughput (INTENT)

Recruiting
Ages 18 to 80 · All sexes · Updated Oct 9, 2026 · NCT07521930

Do Video Recordings of Multidisciplinary Clinics Improve Quality of Life for People With ALS and Their Caregivers?

Recruiting
Ages 18 and older · All sexes · Updated Oct 8, 2026 · NCT07454733

ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Oct 7, 2026 · NCT04363684

Acamprosate in C9orf72 Hexanucleotide Repeat Expansion Amyotrophic Lateral Sclerosis (ACALS)

RecruitingPhase 1
Ages 18 to 99 · All sexes · Updated Oct 1, 2026 · NCT07204977

RAPA-501 Therapy for ALS

RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT04220190

Developing New Ways to Detect Respiratory Impairment Early in ALS

RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07844590

Using Gaze to Enable Head-neck Movements in Patients With Head Drop

Recruiting
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07836751

Controlling Amyotrophic Lateral Sclerosis Motor Neuron Excitability Study

Recruiting
Ages 18 to 80 · All sexes · Updated Sep 10, 2026 · NCT06649955

Effect of Terazosin on ATP Levels in People With Amyotrophic Lateral Sclerosis

RecruitingEarly phase 1
Ages 18 to 80 · All sexes · Updated Sep 9, 2026 · NCT07224269

Usnoflast Neuromuscular Investigation for Treatment Efficacy in Amyotrophic Lateral Sclerosis

RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 1, 2026 · NCT07023835

From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.