Virginia Cancer Specialists, PC, Arlington
Oncology & Hematology Associates of Southwest Virginia, Inc., DBA Blue Ridge Cancer Care, Blacksburg
Virginia Cancer Specialists, PC, Fairfax
and 12 more

RecruitingPhase 3

Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07222800

Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors

NEXT Oncology Virginia, Fairfax

RecruitingPhase 1/2

Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06128551

A First-in-Human Trial of BLU-924 (SAR449336) in Advanced Solid Tumors Harboring KRAS Mutations

Next Oncology Virginia Cancer Specialist, Fairfax

RecruitingPhase 1/2

Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT07629960

A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer

University of Virginia Medical Center, Charlottesville
Mary Washington Healthcare, Fredericksburg
Hematology Oncology Associates of Fredericksburg Admin, Fredericksburg
and 1 more

RecruitingPhase 3

Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT07284849

A Phase II Platform Study to Evaluate Treatment With Cemiplimab Monotherapy or Cemiplimab Plus Fianlimab or Other Novel Combinations in Patients With Colorectal Cancer With Minimal Residual Disease Following Definitive Surgery and Chemotherapy (EMPIRE)

University of Virginia Health, Charlottesville
Bon Secours St. Francis Medical Center, Midlothian
Virginia Commonwealth University - Massey, Richmond

RecruitingPhase 2

Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT07058012

Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays

VCU Massey Comprehensive Cancer Center, Richmond
VCU Community Memorial Health Center, South Hill
VCU Health Tappahannock Hospital, Tappahannock

RecruitingHealthy volunteers welcome

Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT07283939

Five or Ten Year Colonoscopy for 1-2 Non-Advanced Adenomatous Polyps

Kaiser Permanente-Burke Medical Center, Burke
Kaiser Permanente Tysons Corner Medical Center, McLean
VCU Massey Cancer Center at Stony Point, Richmond
and 3 more

Recruiting

Ages 45 to 70 · All sexes · Updated Sep 2, 2026 · NCT05080673

Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease

Kaiser Permanente-Burke Medical Center, Burke
Cancer Specialists of Tidewater Limited, Chesapeake
Peninsula Cancer Institute-Gloucester, Gloucester
and 15 more

RecruitingPhase 2/3

Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT05174169

Family Communications After Genetic Testing

VCU Massey Comprehensive Cancer Center, Richmond
VCU Community Memorial Health Center, South Hill

RecruitingHealthy volunteers welcome

Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT07143487

A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Anti-tumor Activity of CBI-1214 T Cell Engager in Participants With Advanced or Metastatic MSS/MSI-L Colorectal Cancer

NEXT Oncology, Fairfax

RecruitingPhase 1

Ages 18 and older · All sexes · Updated Aug 26, 2026 · NCT07321106

Shield Post-Approval Study Protocol

Tidewater Physician Multispecialty Group Clinical Research, Williamsburg

RecruitingObservational studyHealthy volunteers welcome

Ages 45 to 81 · All sexes · Updated Aug 7, 2026 · NCT06880055

A Phase 1 Dose-escalation Trial of KST-6051 in Participants With Advanced Solid Tumors With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Mutation

NEXT Virginia, Fairfax

RecruitingPhase 1

Ages 18 and older · All sexes · Updated Jun 29, 2026 · NCT07458347

A Study of Fruquintinib Plus FOLFIRI as Second-Line Treatment for Participants With Metastatic Colorectal Cancer (FRUITFUL)

Virginia Oncology Associates, Norfolk
Blue Ridge Cancer Care (Oncology & Hematology Associates of Southwest VA), Salem

RecruitingPhase 2

Ages 18 and older · All sexes · Updated Jun 12, 2026 · NCT07011576

A Study to Learn About Study Medicine ALTA3263 in Adults With Advanced Solid Tumors With KRAS Mutations

Research Site, Fairfax

RecruitingPhase 1

Ages 18 and older · All sexes · Updated Jun 10, 2026 · NCT06835569

Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors

NEXT Oncology Virginia, Fairfax

RecruitingPhase 1

Ages 18 and older · All sexes · Updated Jun 3, 2026 · NCT06040541

Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS

Next Oncology Virginia, Fairfax

RecruitingPhase 1/2

Ages 18 and older · All sexes · Updated May 15, 2026 · NCT05379985

Phase 1/2 Dose Finding, Safety and PK Study in Advanced Refractory Solid Tumors

NEXT, Virginia, Fairfax

RecruitingPhase 1/2

Ages 18 and older · All sexes · Updated Feb 17, 2026 · NCT07145255

Study of Perioperative Dostarlimab in Participants With Untreated T4N0 or Stage III dMMR/MSI-H Resectable Colon Cancer

GSK Investigational Site, Richmond

RecruitingPhase 3

Ages 18 and older · All sexes · Updated Jan 23, 2026 · NCT05855200

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

Massive Bio SYNERGY-AI site, Charlottesville

RecruitingObservational study

All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.