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Family Communications After Genetic Testing

RecruitingHealthy volunteers welcome

Evaluation of Provider vs. Patient Mediated Cascade Genetic Testing of First-Degree Relatives of Patients With Newly Diagnosed Colorectal Cancer

Who can join

Ages 18 and older · All sexes · Healthy volunteers welcome

Full eligibility criteria
Inclusion Criteria:

* STEP 1 PROBANDS: Age \>= 18 years
* STEP 1 PROBANDS: Patients with a newly diagnosed (within 3 months of registration), primary colorectal adenocarcinoma, stage I to IV

  * Histologically proven stage I to IV colon or rectal adenocarcinoma (any T or N, M+). Tumors deemed to originate in the colon can extend into/involve the small bowel (e.g., those at the ileocecal valve). Tumors will be regarded as originating in the colon if the entire tumor is in the colon. In the case of rectal involvement, the cancer will be considered a rectal primary
  * Patients with more than one primary colon adenocarcinoma are eligible
* STEP 1 PROBANDS: No patients with stage 0 or in-situ colorectal cancer
* STEP 1 PROBANDS: Patients who have had prior malignancies are eligible, including non-invasive cancers
* STEP 1 PROBANDS: Patients with synchronous second malignancies are eligible
* STEP 1 PROBANDS: Have not received germline testing in the 2 years prior to enrollment or known hereditary colon cancer syndromes
* STEP 1 PROBANDS: Patients must have at least 2 living FDRs who meet the eligibility criteria, with whom the patient is willing to share their cancer diagnosis
* STEP 1 PROBANDS: In order to complete the mandatory patient-completed measures and view the video and receive genetic education and counseling, participants must be able to speak and read English or Spanish
* STEP 1 PROBANDS: No known diagnosis of dementia or cognitive impairment. Persons with impaired decision-making capacity are ineligible as they need to be able to understand genetic test results, its implications for the patient and family, and explain genetic test results to their family members

  \* No persons with a known psychiatric or documented developmental disorder that affects cognitive or emotional functions to the extent that the capacity for judgment and reason is significantly diminished, such that they cannot participate based on the judgment of the treating physician
* STEP 2 PROBANDS: Probands positive for a pathogenic germline variant (PGV) in a cancer susceptibility gene
* FDRs: Age \>= 18 years
* FDRs: Have not previously received germline genetic testing or known hereditary colon cancer syndromes
* FDRs: FDRs must reside within the United States, as genetic testing from LabCorp is only available to United States (U.S.) residents
* FDRs: In order to complete the mandatory patient-completed measures, participants must be able to speak and read English or Spanish

Exclusion Criteria:

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About the study

This clinical trial compares patient (proband)-mediated communication to provider-mediated communication for improving genetic testing in first-degree relatives of patients with newly diagnosed colorectal cancer. It is estimated that 30% of cases of colorectal cancer have a genetic basis and about 15% of these patients have a disease-causing (pathogenic) inherited (germline) variant in a cancer susceptibility gene. Most individuals carrying a pathogenic germline variant are unaware of their cancer risk and may not meet guidelines for genetic testing. Identifying pathogenic germline variants or hereditary cancer syndromes in cancer patients has important implications for their at-risk relatives who may not know that they are at high risk for cancer. The burden of communicating this risk to first-degree relatives often falls on the patients, who may lack sufficient knowledge to correctly share and explain their genetic test results. Receiving provider-mediated communication of genetic testing results may be more effective at communicating genetic risk to first-degree relatives than the usual practice of proband-mediated communication.

What is being tested

Sponsor: Alliance for Clinical Trials in Oncology · Participants: 4,186 · Started: Apr 6, 2026

Contact the study team

Official record on ClinicalTrials.gov — NCT07143487

Locations in the U.S.

AlaskaAlaska Breast Care and Surgery LLC, Anchorage
Alaska Oncology and Hematology LLC, Anchorage
Alaska Women's Cancer Care, Anchorage
Anchorage Associates in Radiation Medicine, Anchorage
Katmai Oncology Group, Anchorage
Providence Alaska Medical Center, Anchorage
Fairbanks Memorial Hospital, Fairbanks
ArizonaCancer Center at Saint Joseph's, Phoenix
ArkansasMercy Hospital Fort Smith, Fort Smith
CARTI Cancer Center, Little Rock
CaliforniaMission Hope Medical Oncology - Arroyo Grande, Arroyo Grande
Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank
Marshall Cancer Center, Cameron Park
Mercy Cancer Center - Carmichael, Carmichael
Mercy San Juan Medical Center, Carmichael
Enloe Medical Center, Chico
Mercy Cancer Center - Elk Grove, Elk Grove
Fremont - Rideout Cancer Center, Marysville
Mercy Cancer Center, Merced
Providence Queen of The Valley, Napa
Mercy Cancer Center - Rocklin, Rocklin
Mercy Cancer Center - Sacramento, Sacramento
Pacific Central Coast Health Center-San Luis Obispo, San Luis Obispo
Mission Hope Medical Oncology - Santa Maria, Santa Maria
Providence Medical Foundation - Santa Rosa, Santa Rosa
Providence Santa Rosa Memorial Hospital, Santa Rosa
Saint Helena Hospital, St. Helena
Saint Joseph's Medical Center, Stockton
Gene Upshaw Memorial Tahoe Forest Cancer Center, Truckee
Woodland Memorial Hospital, Woodland
ColoradoPenrose-Saint Francis Healthcare, Colorado Springs
Rocky Mountain Cancer Centers-Penrose, Colorado Springs
Saint Francis Cancer Center, Colorado Springs
CommonSpirit Cancer Center Mercy, Durango
Mercy Medical Center, Durango
CommonSpirit Saint Anthony Hospital Cancer Center, Lakewood
Longmont United Hospital, Longmont
Saint Mary Corwin Medical Center, Pueblo
Saint Anthony North Hospital, Westminster
FloridaHoly Cross Hospital, Fort Lauderdale
IdahoSaint Alphonsus Cancer Care Center-Boise, Boise
Saint Luke's Cancer Institute - Boise, Boise
Saint Alphonsus Cancer Care Center-Caldwell, Caldwell
Kootenai Health - Coeur d'Alene, Coeur d'Alene
Saint Luke's Cancer Institute - Fruitland, Fruitland
Idaho Urologic Institute-Meridian, Meridian
Saint Luke's Cancer Institute - Meridian, Meridian
Saint Alphonsus Cancer Care Center-Nampa, Nampa
Saint Luke's Cancer Institute - Nampa, Nampa
Kootenai Clinic Cancer Services - Post Falls, Post Falls
Kootenai Clinic Cancer Services - Sandpoint, Sandpoint
Saint Luke's Cancer Institute - Twin Falls, Twin Falls
IllinoisOSF Saint Anthony's Health Center, Alton
Illinois CancerCare-Bloomington, Bloomington
Illinois CancerCare-Canton, Canton
Memorial Hospital of Carbondale, Carbondale
SIH Cancer Institute, Carterville
Illinois CancerCare-Carthage, Carthage
Centralia Oncology Clinic, Centralia
Carle at The Riverfront, Danville
Cancer Care Specialists of Illinois - Decatur, Decatur
Decatur Memorial Hospital, Decatur
Illinois CancerCare-Dixon, Dixon
Carle Physician Group-Effingham, Effingham
Crossroads Cancer Center, Effingham
Illinois CancerCare-Eureka, Eureka
Illinois CancerCare-Galesburg, Galesburg
Illinois CancerCare-Kewanee Clinic, Kewanee
Illinois CancerCare-Macomb, Macomb
Carle Physician Group-Mattoon/Charleston, Mattoon
SSM Health Good Samaritan, Mount Vernon
Carle BroMenn Medical Center, Normal
Carle Cancer Institute Normal, Normal
Cancer Care Center of O'Fallon, O'Fallon
HSHS Saint Elizabeth's Hospital, O'Fallon
Illinois CancerCare-Ottawa Clinic, Ottawa
Illinois CancerCare-Pekin, Pekin
Illinois CancerCare-Peoria, Peoria
Methodist Medical Center of Illinois, Peoria
Illinois CancerCare-Peru, Peru
Valley Radiation Oncology, Peru
Illinois CancerCare-Princeton, Princeton
OSF Saint Anthony Medical Center, Rockford
Southern Illinois University School of Medicine, Springfield
Springfield Clinic, Springfield
Springfield Memorial Hospital, Springfield
Carle Cancer Center, Urbana
Illinois CancerCare - Washington, Washington
IndianaReid Health, Richmond
KansasCentral Care Cancer Center - Garden City, Garden City
Central Care Cancer Center - Great Bend, Great Bend
Mercy Hospital Pittsburg, Pittsburg
Cotton O'Neil Cancer Center / Stormont Vail Health, Topeka
KentuckyCommonSpirit Saint Joseph Hospital - Bardstown, Bardstown
Commonwealth Cancer Center-Corbin, Corbin
CommonSpirit Saint Joseph Hospital - Lexington, Lexington
CommonSpirit Saint Joseph Medical Center - East Lexington, Lexington
Saint Joseph Radiation Oncology Resource Center, Lexington
CommonSpirit Saint Joseph Hospital London, London
CommonSpirit Saint Joseph Hospital Mount Sterling, Mount Sterling
MarylandSinai Hospital of Baltimore, Baltimore
Northwest Hospital Center, Randallstown
UM Saint Joseph Medical Center, Towson
William E Kahlert Regional Cancer Center/Sinai Hospital, Westminster
MichiganMyMichigan Medical Center Gratiot, Alma
MyMichigan Medical Center Alpena, Alpena
Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor
Bronson Battle Creek, Battle Creek
Trinity Health IHA Medical Group Hematology Oncology - Brighton, Brighton
Trinity Health Medical Center - Brighton, Brighton
Trinity Health IHA Medical Group Hematology Oncology - Canton, Canton
Trinity Health Medical Center - Canton, Canton
Chelsea Hospital, Chelsea
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea
Hematology Oncology Consultants-Clarkston, Clarkston
Henry Ford Health Saint John Hospital, Detroit
Henry Ford River District Hospital, East China Township
Cancer Hematology Centers - Flint, Flint
Genesee Hematology Oncology PC, Flint
Genesys Hurley Cancer Institute, Flint
Hurley Medical Center, Flint
MyMichigan Medical Center Gladwin, Gladwin
Corewell Health Grand Rapids Hospitals - Butterworth Hospital, Grand Rapids
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital, Grand Rapids
Henry Ford Saint John Hospital - Academic, Grosse Pointe Woods
Henry Ford Saint John Hospital - Breast, Grosse Pointe Woods
Henry Ford Saint John Hospital - Van Elslander, Grosse Pointe Woods
Beacon Kalamazoo, Kalamazoo
Beacon Kalamazoo Cancer Center, Kalamazoo
Bronson Methodist Hospital, Kalamazoo
West Michigan Cancer Center, Kalamazoo
University of Michigan Health - Sparrow Lansing, Lansing
Trinity Health Saint Mary Mercy Livonia Hospital, Livonia
Henry Ford Saint John Hospital - Macomb Medical, Macomb
Henry Ford Warren Hospital - Breast Macomb, Macomb
MyMichigan Medical Center Midland, Midland
MyMichigan Medical Center Mount Pleasant, Mount Pleasant
Corewell Health Lakeland Hospitals - Niles Hospital, Niles
Michigan Healthcare Professionals Pontiac, Pontiac
Newland Medical Associates-Pontiac, Pontiac
Trinity Health Saint Joseph Mercy Oakland Hospital, Pontiac
Corewell Health Reed City Hospital, Reed City
MyMichigan Medical Center Saginaw, Saginaw
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center, Saint Joseph
Corewell Health Lakeland Hospitals - Saint Joseph Hospital, Saint Joseph
MyMichigan Medical Center Tawas, Tawas City
Munson Medical Center, Traverse City
Henry Ford Health Warren Hospital, Warren
Henry Ford Madison Heights Hospital - Breast, Warren
Henry Ford Warren Hospital - GLCMS, Warren
University of Michigan Health - West, Wyoming
Huron Gastroenterology PC, Ypsilanti
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti
MinnesotaRiverwood Healthcare Center, Aitkin
Essentia Health - Baxter Clinic, Baxter
Essentia Health Saint Joseph's Medical Center, Brainerd
Minnesota Oncology - Burnsville, Burnsville
Minnesota Oncology Hematology PA-Chaska, Chaska
Mercy Hospital, Coon Rapids
Minnesota Oncology - Coon Rapids, Coon Rapids
Essentia Health - Saint Joseph's Crosslake Clinic, Crosslake
Essentia Health - Deer River Clinic, Deer River
Essentia Health Saint Mary's - Detroit Lakes Clinic, Detroit Lakes
Essentia Health Cancer Center, Duluth
Essentia Health Saint Mary's Medical Center, Duluth
Miller-Dwan Hospital, Duluth
Fairview Southdale Hospital, Edina
Minnesota Oncology - Edina, Edina
Essentia Health - Ely Clinic, Ely
Essentia Health - Fosston, Fosston
Essentia Health Hibbing Clinic, Hibbing
Essentia Health - International Falls Clinic, International Falls
Fairview Clinics and Surgery Center Maple Grove, Maple Grove
Minnesota Oncology - Maple Grove, Maple Grove
Minnesota Oncology Hematology PA-Maplewood, Maplewood
Saint John's Hospital - Healtheast, Maplewood
Abbott-Northwestern Hospital, Minneapolis
Hennepin County Medical Center, Minneapolis
Essentia Health - Moose Lake Clinic, Moose Lake
New Ulm Medical Center, New Ulm
Essentia Health - Park Rapids, Park Rapids
Essentia Health - Saint Joseph's Pequot Lakes Clinic, Pequot Lakes
Essentia Health - Saint Joseph's Pine River Clinic, Pine River
Fairview Northland Medical Center, Princeton
North Memorial Medical Health Center, Robbinsdale
Park Nicollet Clinic - Saint Louis Park, Saint Louis Park
Regions Hospital, Saint Paul
United Hospital, Saint Paul
Essentia Health Sandstone, Sandstone
Saint Francis Regional Medical Center, Shakopee
Essentia Health - Saint Joseph's Staples Clinic, Staples
Lakeview Hospital, Stillwater
Essentia Health Virginia Clinic, Virginia
Ridgeview Medical Center, Waconia
Rice Memorial Hospital, Willmar
Minnesota Oncology Hematology PA-Woodbury, Woodbury
Fairview Lakes Medical Center, Wyoming
MissouriMercy Oncology and Hematology - Clayton-Clarkson, Ballwin
Central Care Cancer Center - Bolivar, Bolivar
Cox Cancer Center Branson, Branson
Mercy Cancer Center - Cape Girardeau, Cape Girardeau
Saint Francis Medical Center, Cape Girardeau
Parkland Health Center - Farmington, Farmington
Freeman Health System, Joplin
Mercy Hospital Joplin, Joplin
Lake Regional Hospital, Osage Beach
Mercy Clinic-Rolla-Cancer and Hematology, Rolla
Phelps Health Delbert Day Cancer Institute, Rolla
Heartland Regional Medical Center, Saint Joseph
Sainte Genevieve County Memorial Hospital, Sainte Genevieve
CoxHealth South Hospital, Springfield
Mercy Hospital Springfield, Springfield
Mercy Hospital Saint Louis, St Louis
Mercy Hospital South, St Louis
Mercy Infusion Center - Chippewa, St Louis
Missouri Baptist Medical Center, St Louis
Missouri Baptist Sullivan Hospital, Sullivan
Mercy Hospital Washington, Washington
MontanaCommunity Hospital of Anaconda, Anaconda
Billings Clinic Cancer Center, Billings
Bozeman Health Deaconess Hospital, Bozeman
Benefis Sletten Cancer Institute, Great Falls
Great Falls Clinic, Great Falls
Hi-Line Sletten Cancer Center, Havre
Benefis Helena Specialty Center, Helena
Logan Health Medical Center, Kalispell
Community Medical Center, Missoula
Saint Patrick Hospital - Community Hospital, Missoula
NebraskaCHI Health Saint Francis, Grand Island
CHI Health Good Samaritan, Kearney
Alegent Health Bergan Mercy Medical Center, Omaha
Alegent Health Immanuel Medical Center, Omaha
Alegent Health Lakeside Hospital, Omaha
NevadaRenown Regional Medical Center, Reno
North CarolinaSoutheastern Medical Oncology Center-Clinton, Clinton
CaroMont Regional Medical Center, Gastonia
Southeastern Medical Oncology Center-Goldsboro, Goldsboro
Southeastern Medical Oncology Center-Jacksonville, Jacksonville
CaroMont Health - Lincoln Cancer Center, Lincolnton
North DakotaEssentia Health Cancer Center-South University Clinic, Fargo
Essentia Health - Jamestown Clinic, Jamestown
OhioAultman Alliance Community Hospital, Alliance
Indu and Raj Soin Medical Center, Beavercreek
Saint Elizabeth Boardman Hospital, Boardman
Aultman Health Foundation, Canton
Bethesda North Hospital, Cincinnati
Good Samaritan Hospital - Cincinnati, Cincinnati
Oncology Hematology Care Inc-Kenwood, Cincinnati
TriHealth Cancer Institute-Anderson, Cincinnati
TriHealth Cancer Institute-Westside, Cincinnati
University of Cincinnati Cancer Center-UC Medical Center, Cincinnati
Dayton Physician LLC - Englewood, Dayton
Armes Family Cancer Center, Findlay
Blanchard Valley Hospital, Findlay
Dayton Physicians LLC-Atrium, Franklin
Wayne Hospital, Greenville
Greater Dayton Cancer Center, Kettering
Kettering Medical Center, Kettering
Saint Joseph Warren Hospital, Warren
University of Cincinnati Cancer Center-West Chester, West Chester
Saint Elizabeth Youngstown Hospital, Youngstown
OklahomaMercy Hospital Oklahoma City, Oklahoma City
OregonSaint Alphonsus Cancer Care Center-Baker City, Baker City
Saint Charles Health System, Bend
Clackamas Radiation Oncology Center, Clackamas
Bay Area Hospital, Coos Bay
Providence Hood River Memorial Hospital, Hood River
Providence Newberg Medical Center, Newberg
Saint Alphonsus Cancer Care Center-Ontario, Ontario
Providence Willamette Falls Medical Center, Oregon City
Providence Portland Medical Center, Portland
Providence Saint Vincent Medical Center, Portland
Saint Charles Health System-Redmond, Redmond
PennsylvaniaLehigh Valley Hospital-Cedar Crest, Allentown
Lehigh Valley Hospital - Muhlenberg, Bethlehem
Pocono Medical Center, East Stroudsburg
Lehigh Valley Hospital-Hazleton, Hazleton
Redeemer Health, Meadowbrook
South DakotaRapid City Regional Hospital, Rapid City
VirginiaVCU Massey Comprehensive Cancer Center, Richmond
VCU Community Memorial Health Center, South Hill
WashingtonProvidence Regional Cancer System-Aberdeen, Aberdeen
PeaceHealth Saint Joseph Medical Center, Bellingham
Providence Regional Cancer System-Centralia, Centralia
Swedish Cancer Institute-Edmonds, Edmonds
Providence Regional Cancer Partnership, Everett
Swedish Cancer Institute-Issaquah, Issaquah
Kadlec Clinic Hematology and Oncology, Kennewick
Providence Regional Cancer System-Lacey, Lacey
PeaceHealth Saint John Medical Center, Longview
Skagit Regional Health Cancer Care Center, Mount Vernon
Swedish Medical Center-Ballard Campus, Seattle
Swedish Medical Center-Cherry Hill, Seattle
Swedish Medical Center-First Hill, Seattle
PeaceHealth United General Medical Center, Sedro-Woolley
Saint Joseph Medical Center Hematology and Oncology - Silverdale, Silverdale
Cancer Care Northwest - Spokane South, Spokane
Cancer Care Northwest-North Spokane, Spokane
Cancer Care Northwest-Valley, Spokane
PeaceHealth Southwest Medical Center, Vancouver
Providence Saint Mary Regional Cancer Center, Walla Walla
WisconsinDuluth Clinic Ashland, Ashland
Northwest Wisconsin Cancer Center, Ashland
Essentia Health-Hayward Clinic, Hayward
Tamarack Health Hayward Medical Center, Hayward
Cancer Center of Western Wisconsin, New Richmond
Essentia Health-Spooner Clinic, Spooner
Essentia Health Saint Mary's Hospital - Superior, Superior
WyomingMemorial Hospital of Laramie County, Cheyenne
Billings Clinic-Cody, Cody

Conditions

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.