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Colorectal Cancer clinical trials in Illinois
49 studies for Colorectal Cancer are looking for participants at sites in Illinois.
Cities in Illinois
- Chicago32 studies
- Arlington Heights12 studies
- Peoria12 studies
- Evanston10 studies
- Cicero9 studies
- Springfield9 studies
- North Peoria7 studies
- Carbondale7 studies
- Galesburg7 studies
- Bloomington7 studies
- Danville6 studies
- Waukegan6 studies
- Decatur6 studies
- Champaign6 studies
- Charleston5 studies
- Elgin4 studies
- Naperville4 studies
- Aurora3 studies
- Rockford3 studies
A Study to Evaluate the Safety, Pharmacokinetics, and Anti-Tumor Activity of VVD-133214 as Monotherapy and in Combination in Participants With Advanced Solid Tumors
- University of Chicago, Chicago
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT06004245A Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients With Metastatic Colorectal Cancer (INTRINSIC)
- Illinois Cancer Specialists, Arlington Heights
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 6, 2026 · NCT04929223Evaluating Whether an Educational Website Called Current Together After Cancer (CTAC) Improves Follow-up Care for Colorectal Cancer Survivors
- OSF Saint Anthony's Health Center, Alton
- Illinois CancerCare-Bloomington, Bloomington
- Illinois CancerCare-Canton, Canton
- and 32 more
RecruitingPhase 3Healthy volunteers welcome
Ages 18 and older · All sexes · Updated Nov 6, 2026 · NCT07018869Beamion BCGC-1: A Study to Find a Suitable Dose of Zongertinib Used Alone and in Combination With Other Treatments to Test Whether it Helps People With Different Types of HER2+ Cancer That Has Spread
- Orchard Healthcare Research Inc.- Skokie, Skokie
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT06324357Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer
- Illinois CancerCare-Bloomington, Bloomington
- Illinois CancerCare-Canton, Canton
- SIH Cancer Institute, Carterville
- and 18 more
RecruitingObservational study
Ages 60 and older · All sexes · Updated Nov 5, 2026 · NCT03998202Pressurized Intraperitoneal Aerosolized Chemotherapy With Mitomycin for the Treatment of Unresectable Appendix or Colorectal Cancer With Peritoneal Metastases, The IMPACT Trial
- City of Hope at Chicago, Zion
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT07271355A Study of Precemtabart Tocentecan With or Without Bevacizumab Compared to Trifluridine/Tipiracil Plus Bevacizumab in Participants With Previously Treated Metastatic Colorectal Cancer (PROCEADE-CRC-03)
- Illinois Cancer Specialists, Arlington Heights
- Illinois CancerCare PC, Peoria
- Springfield Clinic, Springfield
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT07549412Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal Cancer
- Clinical Study Site, Chicago
- Clinical Study Site, Chicago
- Clinical Study Site, Elmhurst
- and 1 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT07228832Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
- OSF Saint Anthony's Health Center, Alton
- Advocate Outpatient Center - Aurora, Aurora
- Advocate Good Shepherd Hospital, Barrington
- and 52 more
RecruitingObservational studyHealthy volunteers welcome
Ages 40 to 75 · All sexes · Updated Nov 4, 2026 · NCT05334069Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics
- OSF Saint Anthony's Health Center, Alton
- Rush-Copley Medical Center, Aurora
- Advocate Outpatient Center - Aurora, Aurora
- and 45 more
RecruitingObservational study
Ages 18 and older · All sexes · Updated Nov 4, 2026 · NCT06418204A Study of Amivantamab and mFOLFOX6 or FOLFIRI Versus Cetuximab and mFOLFOX6 or FOLFIRI as First-line Treatment in Participants With KRAS/NRAS and BRAF Wild-type Unresectable or Metastatic Left-sided Colorectal Cancer
- Illinois Cancer Specialists, Arlington Heights
- Illinois CancerCare, Peoria
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT06662786A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy
- Illinois Cancer Specialists, Arlington Heights
- Illinois CancerCare, Peoria
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT06750094Family Communications After Genetic Testing
- OSF Saint Anthony's Health Center, Alton
- Advocate Outpatient Center - Aurora, Aurora
- Advocate Good Shepherd Hospital, Barrington
- and 46 more
RecruitingHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT07143487Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, ERASur Trial
- University of Illinois, Chicago
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT05673148A Study to Investigate CEA-PRIT 2.0 in Participants With Metastatic Colorectal Cancer (mCRC)
- The University of Chicago Medical Center, Chicago
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT07416552FITting Non-invasive Tests in Lynch Syndrome Surveillance
- The University of Chicago Medical Center, Chicago
Recruiting
Ages 20 to 80 · All sexes · Updated Nov 2, 2026 · NCT06898996A Study to Evaluate the Efficacy and Safety of Standard-of-Care Chemotherapy and Bevacizumab With or Without INCA33890 in the First-Line Treatment of Metastatic Microsatellite Stable Colorectal Cancer
- Sih Cancer Institute, Carterville
- University of Illinois Cancer Center, Chicago
- Alexian Brothers Medical Center, Elk Grove Village
- and 2 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 30, 2026 · NCT07284849A Study to Evaluate the Adverse Events, and Efficacy of Intravenous (IV) of Telisotuzumab Adizutecan in Combination With IV Oxaliplatin, Fluorouracil, Folinic Acid/Leucovorin, Bevacizumab, Panitumumab in Adult Participants With Metastatic Colorectal Cancer
- University of Chicago Medical Center /ID# 271688, Chicago
- Hope And Healing Cancer Services /ID# 271562, Hinsdale
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 27, 2026 · NCT06820463A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects With Recurrent or Metastatic Solid Tumors (IDeate-PanTumor02)
- Orchard Healthcare Research Inc, Skokie
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Oct 26, 2026 · NCT06330064A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer
- University of Chicago Medical Center, Chicago
RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Oct 23, 2026 · NCT07221357Evaluation of the Safety and Efficacy of Treatment w/High Dose Melphalan Given Directly Into the Liver Followed by Treatment w/Approved Cancer Treatment or Approved Cancer Treatment Alone in Patients w/ Metastatic Colorectal Cancer w/Liver Dominant Disease
- Northwestern University - Feinberg School of Medicine, Chicago
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 20, 2026 · NCT06607458A Study to Access Intravenous (IV) Telisotuzumab Adizutecan in Combination With IV Bevacizumab Compared to Standard of Care IV Bevacizumabin Combination With Oral Trifluridine and Tipiracil in Adult Participants With Refractory Metastatic Colorectal Cancer
- University of Chicago Medical Center /ID# 279365, Chicago
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 19, 2026 · NCT07525206A Study to Assess Adverse Events and Change in Disease Activity in Adult Participants Receiving Intravenously Infused Telisotuzumab Adizutecan Alone or With Standard of Care in Participants With Post Adjuvant Circulating Tumor DNA Positive Colorectal Cancer and No Radiographic Evidence of Disease
- University of Chicago Medical Center /ID# 274742, Chicago
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 9, 2026 · NCT07023289Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer
- Illinois Cancer Specialists, Arlington Heights
- Illinois CancerCare - Bloomington, Bloomington
- Illinois Cancer Specialists, Chicago
- and 10 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 8, 2026 · NCT07222800AVA6103 in Subjects With Locally Advanced or Metastatic Selected Solid Tumors
- The University of Chicago, Chicago
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 5, 2026 · NCT07454642Colonoscopy vs Stool Testing for Older Adults With Colon Polyps
- Northwestern Memorial Hospital, Chicago
Recruiting
Ages 65 to 82 · All sexes · Updated Oct 2, 2026 · NCT05612347Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors
- Exelixis Clinical Site #26, Chicago
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT05176483PRE-ISPY Phase I/II Oncology Platform Program
- The University of Chicago Medicine Comprehensive Cancer Center, Chicago
- UChicago Medicine Comprehensive Cancer Center at Silver Cross Hospital, New Lenox
- UChicago Medicine Orland Park, Orland Park
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT05868226Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial
- Northwestern University, Chicago
- University of Chicago Comprehensive Cancer Center, Chicago
- Northwestern Medicine Cancer Center Old Irving Park, Chicago
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT05863195Manipulation of the Gut Microbiome by a Standardized Preoperative Diet to Prevent Colorectal Cancer Recurrence and Metastasis Following Surgery
- University of Chicago, Chicago
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT06349590SIBYL: obServation of Therapy Response With lIquid BiopsY evaLuation
- Orchard Healthcare Research Inc., Skokie
RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT05935384Clinical Trial of an Anti-cancer Drug, CA-4948 (Emavusertib), in Combination With Chemotherapy Treatment (FOLFOX Plus Bevacizumab) in Metastatic Colorectal Cancer
- Memorial Hospital East, Shiloh
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT06696768Study of Sotorasib, Panitumumab and FOLFIRI Versus FOLFIRI With or Without Bevacizumab-awwb in Treatment-naïve Participants With Metastatic Colorectal Cancer With KRAS p.G12C Mutation
- Insight Research Institute, Chicago
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT06252649Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors
- Lurie Children's Hospital-Chicago, Chicago
RecruitingPhase 1/2
12 Months – 30 Years · All sexes · Updated Aug 25, 2026 · NCT04851119Minimal Residual Disease Testing for the Early Detection of Cancer Recurrence in Resectable Stage II-IV Colorectal Cancer Patients
- City of Hope at Chicago, Zion
Recruiting
Ages 18 and older · All sexes · Updated Aug 12, 2026 · NCT07125729Safely Optimizing Body Weight With Mifomelatide (TCMCB07) in Patients With Newly Diagnosed Colorectal Cancer (CRC) or Pancreatic Ductal Adenocarcinoma (PDAC) Undergoing Chemotherapy
- Northwestern University - Robert H. Lurie Comprehensive Cancer Center, Chicago
- Hope and Healing Cancer Services, Hinsdale
- Orchard Healthcare Research, Skokie
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jul 15, 2026 · NCT06937177Colorectal Metastasis to Liver Extraction With Auxiliary Transplant and Delayed Resection
- Northwestern University-Comprehensive Transplant Center, Chicago
RecruitingObservational study
Ages 18 and older · All sexes · Updated Jul 10, 2026 · NCT06698146CARE Tool Study Aim 3
- Alton Memorial Hospital, Alton
Recruiting
Ages 18 and older · All sexes · Updated Jul 8, 2026 · NCT07296887A Trial to Evaluate the Safety and Activity of Fruquintinib in Minority Populations With Advanced, Previously Treated Colorectal Cancer
- Hope and Healing Cancer Services, Hinsdale
RecruitingPhase 4
Ages 18 and older · All sexes · Updated Jul 7, 2026 · NCT06562543A Study to Investigate ALE.P03 as Monotherapy in Adult Patients With Selected Advanced or Metastatic CLDN1+ Solid Tumors
- The University of Chicago Medical Center - Oncology, Chicago
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Jul 2, 2026 · NCT07169734From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.