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Head and Neck Squamous Cell Carcinoma clinical trials in South Carolina
21 studies for Head and Neck Squamous Cell Carcinoma are looking for participants at sites in South Carolina.
Cities in South Carolina
High-dose Prophylactic Gabapentin (HOPE) vs. Placebo to Prevent Opioid Use for Oral Mucositis Pain During Concurrent Chemoradiation for Head and Neck Cancer
- Gibbs Cancer Center-Pelham, Greer
- Spartanburg Medical Center, Spartanburg
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06992427FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC
- Site#0104, Charleston
RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06788990Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors
- Exelixis Clinical Site #9, Myrtle Beach
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT05176483Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment
- Medical University of South Carolina, Charleston
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06589804Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma
- Medical University of South Carolina, Charleston
RecruitingPhase 2
Ages 18 to 79 · All sexes · Updated Sep 22, 2026 · NCT04671667Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors
- PRISMA Health/ITOR, Greenville
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT05983432Omission of Postoperative Radiation in HPV-Associated Oropharyngeal Cancer Using ctHPVDNA Surveillance (OPERATION)
- Medical University of South Carolina, Charleston
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT07513389ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation
- Carolina Urologic Research Center, Myrtle Beach
RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT05059444A Phase 1 Study of NRM-823 in Participants With Locally Advanced or Metastatic Refractory Solid Tumors
- Normunity Investigational Site, Charleston
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT07182149Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity Cancer
- Medical University of South Carolina, Charleston
RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT04333537Testing the Addition of the Drug BMX-001, a Radioprotector, or a Placebo to the Usual Chemoradiation Therapy for Patients With Head and Neck Cancer
- Lancaster Radiation Therapy Center, Lancaster
- Rock Hill Radiation Therapy Center, Rock Hill
- Levine Cancer Institute-Rock Hill, Rock Hill
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT06532279Intraoperative Molecular Imaging Using ICG for Head and Neck Tumors
- Medical University of South Carolina Hollings Cancer Center, Charleston
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jul 7, 2026 · NCT07149207A Study of Dostarlimab vs Placebo After Chemoradiation in Adult Participants With Locally Advanced Unresected Head and Neck Squamous Cell Carcinoma
- GSK Investigational Site, Charleston
RecruitingPhase 3
Ages 18 and older · All sexes · Updated May 26, 2026 · NCT06256588DB-1311 in Combination With BNT327 or DB-1305 in Advanced/Metastatic Solid Tumors
- USA03-0, Charleston
RecruitingPhase 2
Ages 18 and older · All sexes · Updated May 22, 2026 · NCT06953089Prospective Observational Study to Validate Circulating HPVDNA and Prognostic Genomic Biomarkers in HPV-associated OPSCC
- Trident Medical Center (HCA Healthcare ), North Charleston
RecruitingObservational study
Ages 18 and older · All sexes · Updated Apr 28, 2026 · NCT04564989Risk Adapted De-Intensification of Radio-Chemotherapy for Oropharyngeal Squamous Cell Carcinoma
- Medical University of South Carolina, Charleston
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Apr 24, 2026 · NCT05268614A Study of Ficlatuzumab in Combination With Cetuximab in Participants With Recurrent or Metastatic (R/M) HPV Negative Head and Neck Squamous Cell Carcinoma
- Medical University of South Carolina (MUSC), Charleston
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Apr 9, 2026 · NCT06064877A Study of DR-0202 in Patients With Locally Advanced or Metastatic, Relapsed or Refractory Carcinomas
- Dren Investigational Site, Greenville
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Jan 7, 2026 · NCT06999187Multi-Site Trial of Navigation vs Treatment as Usual to Improve Initiation of Timely Adjuvant Therapy
- Medical University of South Carolina, Charleston
Recruiting
Ages 18 and older · All sexes · Updated Dec 11, 2025 · NCT05793151A Phase 1/2a Study of DB-1311/BNT324 in Advanced/Metastatic Solid Tumors
- Research Site 123, Charleston
- Research Site 108, Greenville
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Nov 21, 2025 · NCT05914116Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors
- Medical University of South Carolina, Hollings Cancer Center, Charleston
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Aug 15, 2025 · NCT04429542From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.