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Head and Neck Squamous Cell Carcinoma clinical trials in Charleston, SC

14 studies for Head and Neck Squamous Cell Carcinoma are looking for participants at sites in and around Charleston (within about 30 miles). Open a study to see who can join and how to contact the study team.

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FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC

RecruitingPhase 2/3
  • Site#0104, Charleston
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06788990

Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment

RecruitingPhase 3
  • Medical University of South Carolina, Charleston
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06589804

Omission of Postoperative Radiation in HPV-Associated Oropharyngeal Cancer Using ctHPVDNA Surveillance (OPERATION)

RecruitingPhase 2
  • Medical University of South Carolina, Charleston
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT07513389

A Phase 1 Study of NRM-823 in Participants With Locally Advanced or Metastatic Refractory Solid Tumors

RecruitingPhase 1
  • Normunity Investigational Site, Charleston
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT07182149

Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity Cancer

RecruitingPhase 2/3
  • Medical University of South Carolina, Charleston
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT04333537

Intraoperative Molecular Imaging Using ICG for Head and Neck Tumors

RecruitingPhase 2
  • Medical University of South Carolina Hollings Cancer Center, Charleston
Ages 18 and older · All sexes · Updated Jul 7, 2026 · NCT07149207

A Study of Dostarlimab vs Placebo After Chemoradiation in Adult Participants With Locally Advanced Unresected Head and Neck Squamous Cell Carcinoma

RecruitingPhase 3
  • GSK Investigational Site, Charleston
Ages 18 and older · All sexes · Updated May 26, 2026 · NCT06256588

DB-1311 in Combination With BNT327 or DB-1305 in Advanced/Metastatic Solid Tumors

RecruitingPhase 2
  • USA03-0, Charleston
Ages 18 and older · All sexes · Updated May 22, 2026 · NCT06953089

Risk Adapted De-Intensification of Radio-Chemotherapy for Oropharyngeal Squamous Cell Carcinoma

RecruitingPhase 2
  • Medical University of South Carolina, Charleston
Ages 18 and older · All sexes · Updated Apr 24, 2026 · NCT05268614

A Study of Ficlatuzumab in Combination With Cetuximab in Participants With Recurrent or Metastatic (R/M) HPV Negative Head and Neck Squamous Cell Carcinoma

RecruitingPhase 3
  • Medical University of South Carolina (MUSC), Charleston
Ages 18 and older · All sexes · Updated Apr 9, 2026 · NCT06064877

Multi-Site Trial of Navigation vs Treatment as Usual to Improve Initiation of Timely Adjuvant Therapy

Recruiting
  • Medical University of South Carolina, Charleston
Ages 18 and older · All sexes · Updated Dec 11, 2025 · NCT05793151

A Phase 1/2a Study of DB-1311/BNT324 in Advanced/Metastatic Solid Tumors

RecruitingPhase 1/2
  • Research Site 123, Charleston
Ages 18 and older · All sexes · Updated Nov 21, 2025 · NCT05914116

Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors

RecruitingPhase 1
  • Medical University of South Carolina, Hollings Cancer Center, Charleston
Ages 18 and older · All sexes · Updated Aug 15, 2025 · NCT04429542

Head and Neck Squamous Cell Carcinoma trials in other cities

Other studies in Charleston

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.