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Heart Failure clinical trials in Pennsylvania
45 studies for Heart Failure are looking for participants at sites in Pennsylvania.
Cities in Pennsylvania
- Philadelphia31 studies
- Pittsburgh19 studies
- Harrisburg14 studies
- Lancaster5 studies
- Allentown4 studies
- Scranton4 studies
A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF
- Research Site, Media
- Research Site, Philadelphia
- Research Site, Philadelphia
- and 2 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07761117Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction
- Capital Area Research, LLC, Camp Hill
- Penn State Health Milton S. Hershey Medical Center, Hershey
- Hospital of the University of Pennsylvania (University of Pennsylvania School of Medicine), Philadelphia
RecruitingPhase 3
Ages 18 to 85 · All sexes · Updated Sep 24, 2026 · NCT06736574A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart
- Cardiology Consultants of Philadelphia, Yardley
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06935370Cholate Clearance in Fontan and Heart Failure
- Hospital of the University of Pennsylvania, Philadelphia
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07009132Alleviant ALLAY-HFrEF Study
- Pinnacle Health Cardiovascular Institute, Harrisburg
Recruiting
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT06812533Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
- Abington Medical Specialists, Horsham
- University of Pittsburgh Medical Center, Pittsburgh
RecruitingPhase 3
Ages 18 to 99 · All sexes · Updated Sep 16, 2026 · NCT07037459Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin
- Research Site, Camp Hill
- Research Site, Horsham
- Research Site, Philadelphia
- and 3 more
RecruitingPhase 3
Ages 40 and older · All sexes · Updated Sep 15, 2026 · NCT06677060Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function
- Research Site, Abington
- Research Site, Camp Hill
- Research Site, Hershey
- and 1 more
RecruitingPhase 3
Ages 18 to 130 · All sexes · Updated Sep 11, 2026 · NCT06307652A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients
- Philadelphia, PA Investigative Site 10068, Philadelphia
- Pittsburg, PA Investigative Site 1044, Pittsburgh
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT06008197A Study to Determine the Efficacy and Safety of Finerenone and SGLT2i in Combination in Hospitalized Patients With Heart Failure (CONFIRMATION-HF)
- Philadelphia, PA Investigative Site CON-10068, Philadelphia
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT06024746The WiSE®-UP Study (The WiSE System Utilization & Performance Study)
- Penn State Health, Hershey
RecruitingObservational study
Ages 22 and older · All sexes · Updated Sep 10, 2026 · NCT07098858Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure
- Thomas Jefferson University Hospital, Philadelphia
Recruiting
Ages 18 to 100 · All sexes · Updated Sep 9, 2026 · NCT06310031Safety and Effectiveness of Left Bundle Branch Area Pacing Versus Conventional Cardiac Resynchronization Therapy in Heart Failure
- Penn Presbyterian Medical Center, Philadelphia
Recruiting
Ages 18 and older · All sexes · Updated Sep 4, 2026 · NCT07069738A Study of EDG-15400 in Adults With Heart Failure With Preserved Ejection Fraction (EQUINOX-HFpEF)
- Local Institution - 165, Mechanicsburg
- Local Institution - 124, Pittsburgh
RecruitingPhase 2
Ages 30 to 84 · All sexes · Updated Aug 31, 2026 · NCT07795814Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)
- Children's Hospital of Philadelphia (CHOP) ( Site 0004), Philadelphia
- Children's Hospital of Pittsburgh ( Site 0010), Pittsburgh
RecruitingPhase 2/3
29 Days – 17 Years · All sexes · Updated Aug 28, 2026 · NCT05714085Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure
- Jefferson Abington Hospital, Abington
- Penn Presbyterian Medical Center, Philadelphia
Recruiting
Ages 21 and older · All sexes · Updated Aug 25, 2026 · NCT05677100Optimal Pediatric Heart Transplant Immunosuppression With MicroRNAs
- University of Pittsburgh, Pittsburgh
RecruitingObservational study
Up to age 18 · All sexes · Updated Aug 25, 2026 · NCT06532890NORM-HF Pivotal Study
- University of Pennsylvania, Philadelphia
Recruiting
Ages 18 and older · All sexes · Updated Aug 25, 2026 · NCT07574593Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products
- Allentown
- Bethlehem
- Danville
- and 4 more
RecruitingObservational study
All ages · All sexes · Updated Aug 20, 2026 · NCT00271180LEVEL-2: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF-2
- Tenax Investigational Site, Allentown
- Tenax Investigational Site, Pittsburgh
- Tenax Investigational Site, Wynnewood
RecruitingPhase 3
Ages 18 to 85 · All sexes · Updated Aug 19, 2026 · NCT07288398A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM)
- St. Luke's University Health Network, Bethlehem
- University Of Pittsburgh, Pittsburgh
- Geisinger Health System, Wilkes-Barre
RecruitingObservational study
Ages 18 and older · All sexes · Updated Aug 19, 2026 · NCT05489705A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease
- University of Pittsburgh Medical Center, Mechanicsburg
Recruiting
Ages 18 to 85 · All sexes · Updated Aug 18, 2026 · NCT07214376A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity
- Penn State Hlth Holy Spirit Med Ctr, Camp Hill
- Chambersburg Hospital, Chambersburg
- Doylestown Heath cardiology, Doylestown
- and 2 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT07567001Alleviant ALLAY-HF Study
- Pinnacle Health Cardiovascular Institute, Harrisburg
Recruiting
Ages 40 and older · All sexes · Updated Aug 14, 2026 · NCT05685303Assessment of CCM in HF With Higher Ejection Fraction
- Bryn Mawr Medical Specialists Association, Bryn Mawr
- Penn State Hershey Medical City, Hershey
- Penn Presbyterian Medical Center, Philadelphia
- and 5 more
Recruiting
Ages 18 and older · All sexes · Updated Aug 6, 2026 · NCT05064709A Research Study Comparing Different Doses of CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy
- Capital Area Research LLC, Camp Hill
RecruitingPhase 2
Ages 40 to 84 · All sexes · Updated Aug 5, 2026 · NCT06979362ELEVATE-HFpEF Clinical Study
- Lancaster General Hospital, Lancaster
- Lankenau Institute for Medical Research, Wynnewood
Recruiting
Ages 40 and older · All sexes · Updated Aug 3, 2026 · NCT06678841Synchronized Diaphragmatic Stimulation in Symptomatic Heart Failure
- University of Pennsylvania, Philadelphia
Recruiting
Ages 18 and older · All sexes · Updated Jul 30, 2026 · NCT06552637The HEARTFELT Study
- Connect America, Bala-Cynwyd
Recruiting
Ages 22 and older · All sexes · Updated Jul 28, 2026 · NCT06222099A Study to Learn More About How Safe Finerenone is, When it is Taken for a Longer Time With Standard Treatment, in Children and Young Adults With Heart Failure and Left Ventricular Systolic Dysfunction
- Children's Hospital of Philadelphia - Cardiology, Philadelphia
- UPMC Children's Hospital of Pittsburgh - Cardiology, Pittsburgh
RecruitingPhase 3
Up to age 18 · All sexes · Updated Jun 29, 2026 · NCT07192952PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III
- Penn State Health, Hershey
- UPMC, Pittsburgh
Recruiting
Ages 18 and older · All sexes · Updated Jun 29, 2026 · NCT05934487Quantifying New Heart Muscle Cells
- Children's Hospital of Philadelphia, Philadelphia
- Upmc Children'S Hospital of Pittsburgh, Pittsburgh
Recruiting
30 Days – 1 Year · All sexes · Updated Jun 15, 2026 · NCT06587165A Study to Learn More About How Well Finerenone Works, How Safe it is, and How it Moves Into, Through, and Out of the Body Compared to Placebo When Taken With Standard Treatment in Children With Heart Failure and Left Ventricular Systolic Dysfunction
- Children's Hospital of Philadelphia - Cardiology, Philadelphia
- UPMC Children's Hospital of Pittsburgh - Cardiology, Pittsburgh
RecruitingPhase 3
6 Months – 17 Years · All sexes · Updated Jun 15, 2026 · NCT07188805Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure
- Abington Memorial Hospital, Abington
- Penn State Milton S. Hershey Medical Center, Hershey
- University of Pennsylvania, Philadelphia
- and 1 more
Recruiting
Ages 18 and older · All sexes · Updated Jun 10, 2026 · NCT06526195CCM OPEN HF Registry
- Reading Hospital, West Reading
RecruitingObservational study
Ages 18 and older · All sexes · Updated Apr 23, 2026 · NCT07112924The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR
- Penn Medicine Lancaster General Health, Lancaster
- UPMC Pinnacle Hospitals, Mechanicsburg
- University of Pennsylvania, Philadelphia
- and 2 more
Recruiting
Ages 18 and older · All sexes · Updated Apr 13, 2026 · NCT03142152HeartShare: Combining Omics, Deep Phenotyping, and Electronic Health Records for Heart Failure Subtypes and Treatment Targets
- University of Pennsylvania, Philadelphia
RecruitingObservational studyHealthy volunteers welcome
Ages 30 and older · All sexes · Updated Apr 13, 2026 · NCT05873634Myocardial Mechanisms in Heart Failure With Preserved Ejection Fraction
- University of Pennsylvania, Philadelphia
RecruitingObservational studyHealthy volunteers welcome
Ages 30 and older · All sexes · Updated Apr 9, 2026 · NCT06517186POCUS-Guided Diuresis for Decompensated Heart Failure
- UPMC East, Pittsburgh
- University of Pittsburgh Medical Center, Pittsburgh
- UPMC Presbyterian, Pittsburgh
- and 2 more
Recruiting
Ages 18 and older · All sexes · Updated Feb 17, 2026 · NCT06921603His-Bundle Corrective Pacing in Heart Failure
- University of Pennsylvania, Philadelphia
- Geisinger Wyoming Valley, Wilkes-Barre
Recruiting
Ages 18 and older · All sexes · Updated Feb 9, 2026 · NCT05265520From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.