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Heart Failure clinical trials in Pennsylvania
45 studies for Heart Failure are looking for participants at sites in Pennsylvania.
Cities in Pennsylvania
- Philadelphia31 studies
- Pittsburgh18 studies
- Harrisburg15 studies
- Scranton5 studies
- Lancaster5 studies
- Allentown3 studies
Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)
- Children's Hospital of Philadelphia (CHOP) ( Site 0004), Philadelphia
- Children's Hospital of Pittsburgh ( Site 0010), Pittsburgh
RecruitingPhase 2/3
29 Days – 17 Years · All sexes · Updated Nov 13, 2026 · NCT05714085Synchronized Diaphragmatic Stimulation in Symptomatic Heart Failure
- University of Pennsylvania, Philadelphia
Recruiting
Ages 18 and older · All sexes · Updated Nov 13, 2026 · NCT06552637A Study to Evaluate the Safety and Efficacy of AC01 Compared to Placebo in Participants With Chronic Heart Failure
- Capital Area Research, LLC - Camp Hill, Camp Hill
RecruitingPhase 2
Ages 18 to 85 · All sexes · Updated Nov 12, 2026 · NCT07584967A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart
- Cardiology Consultants of Philadelphia, Yardley
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT06935370INitiation and Titration of Guideline Directed Medical TheRApy in HearT Failure Cardiogenic Shock With ImpElla 5.5 for Cardiac Recovery
- University of Pennsylvania Health System, Philadelphia
- Allegheny General Hospital, Pittsburgh
- UPMC Presbyterian, Pittsburgh
Recruiting
Ages 18 to 80 · All sexes · Updated Nov 12, 2026 · NCT06965504Left vs Left Randomized Clinical Trial
- St. Luke's University Health Network, Allentown
- Lehigh Valley Hospital Inc., Allentown
- Penn Medicine Lancaster General, Lancaster
- and 5 more
Recruiting
Ages 18 and older · All sexes · Updated Nov 12, 2026 · NCT05650658A Randomized Placebo-procedure Controlled Trial of the Enhancor System (PULmonary Artery Denervation) to Evaluate Safety and Efficacy in Patients With Combined Pre- and Post-capillary Pulmonary Hypertension Associated With Left Heart Disease
- University of Pittsburgh Medical Center, Mechanicsburg
- Lankenau Institute for Medical Research, Wynnewood
Recruiting
Ages 18 to 85 · All sexes · Updated Nov 10, 2026 · NCT07214376Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure
- Abington Memorial Hospital, Abington
- Penn State Milton S. Hershey Medical Center, Hershey
- University of Pittsburgh Medical Center (UPMC), Philadelphia
- and 2 more
Recruiting
Ages 18 and older · All sexes · Updated Nov 5, 2026 · NCT06526195Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products
- Allentown
- Bethlehem
- Danville
- and 4 more
RecruitingObservational study
All ages · All sexes · Updated Nov 4, 2026 · NCT00271180Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction
- Capital Area Research, LLC, Camp Hill
- Penn State Health Milton S. Hershey Medical Center, Hershey
- Hospital of the University of Pennsylvania (University of Pennsylvania School of Medicine), Philadelphia
RecruitingPhase 3
Ages 18 to 85 · All sexes · Updated Nov 4, 2026 · NCT06736574Safety and Effectiveness of Left Bundle Branch Area Pacing Versus Conventional Cardiac Resynchronization Therapy in Heart Failure
- Penn Presbyterian Medical Center, Philadelphia
- Geisinger Wyoming Valley, Wilkes-Barre
Recruiting
Ages 18 and older · All sexes · Updated Nov 3, 2026 · NCT07069738ELEVATE-HFpEF Clinical Study
- Lancaster General Hospital, Lancaster
- Lankenau Institute for Medical Research, Wynnewood
Recruiting
Ages 40 and older · All sexes · Updated Nov 3, 2026 · NCT06678841Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
- Abington Medical Specialists, Horsham
- University of Pittsburgh Medical Center, Pittsburgh
RecruitingPhase 3
Ages 18 to 99 · All sexes · Updated Oct 29, 2026 · NCT07037459A Study to Learn More About How Safe Finerenone is, When it is Taken for a Longer Time With Standard Treatment, in Children and Young Adults With Heart Failure and Left Ventricular Systolic Dysfunction
- Children's Hospital of Philadelphia - Cardiology, Philadelphia
- UPMC Children's Hospital of Pittsburgh - Cardiology, Pittsburgh
RecruitingPhase 3
Up to age 18 · All sexes · Updated Oct 27, 2026 · NCT07192952CCM OPEN HF Registry
- Reading Hospital, West Reading
RecruitingObservational study
Ages 18 and older · All sexes · Updated Oct 27, 2026 · NCT07112924Cardiogenic Shock Working Group Registry
- Allegheny General Hospital, Pittsburgh
- University Of Pittsburgh Medical Center, Pittsburgh
RecruitingObservational study
Ages 18 and older · All sexes · Updated Oct 27, 2026 · NCT04682483Assessment of CCM in HF With Higher Ejection Fraction
- Bryn Mawr Medical Specialists Association, Bryn Mawr
- Penn State Hershey Medical City, Hershey
- Penn Presbyterian Medical Center, Philadelphia
- and 5 more
Recruiting
Ages 18 and older · All sexes · Updated Oct 23, 2026 · NCT05064709Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin
- Research Site, Camp Hill
- Research Site, Horsham
- Research Site, Philadelphia
- and 2 more
RecruitingPhase 3
Ages 40 and older · All sexes · Updated Oct 21, 2026 · NCT06677060The HEARTFELT Study
- Connect America, Bala-Cynwyd
Recruiting
Ages 22 and older · All sexes · Updated Oct 19, 2026 · NCT06222099The WiSE®-UP Study (The WiSE System Utilization & Performance Study)
- Penn State Health, Hershey
RecruitingObservational study
Ages 22 and older · All sexes · Updated Oct 16, 2026 · NCT07098858NORM-HF Pivotal Study
- University of Pennsylvania, Philadelphia
- Thomas Jefferson University Hospital, Philadelphia
Recruiting
Ages 18 and older · All sexes · Updated Oct 16, 2026 · NCT07574593A Study to Learn More About How Well Finerenone Works, How Safe it is, and How it Moves Into, Through, and Out of the Body Compared to Placebo When Taken With Standard Treatment in Children With Heart Failure and Left Ventricular Systolic Dysfunction
- Children's Hospital of Philadelphia - Cardiology, Philadelphia
- UPMC Children's Hospital of Pittsburgh - Cardiology, Pittsburgh
RecruitingPhase 3
6 Months – 17 Years · All sexes · Updated Oct 15, 2026 · NCT07188805A Study of EDG-15400 in Adults With Heart Failure With Preserved Ejection Fraction (EQUINOX-HFpEF)
- Local Institution - 16, Mechanicsburg
RecruitingPhase 2
Ages 30 to 84 · All sexes · Updated Oct 13, 2026 · NCT07795814Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function
- Research Site, Abington
- Research Site, Camp Hill
- Research Site, Hershey
- and 1 more
RecruitingPhase 3
Ages 18 to 130 · All sexes · Updated Oct 13, 2026 · NCT06307652Home-Based Exercise Program Using Mobile Technology After Left Ventricular Assist Device Implantation
- University of Pennsylvania, Philadelphia
Recruiting
Ages 18 and older · All sexes · Updated Oct 7, 2026 · NCT06291922Alleviant ALLAY-HFrEF Study
- Pinnacle Health Cardiovascular Institute, Harrisburg
Recruiting
Ages 18 and older · All sexes · Updated Oct 6, 2026 · NCT06812533A Research Study Comparing Different Doses of CDR132L With Placebo on the Structure and Function of the Heart in People With Heart Failure With Preserved Ejection Fraction and Left Ventricular Hypertrophy
- Capital Area Research LLC, Camp Hill
RecruitingPhase 2
Ages 40 to 84 · All sexes · Updated Oct 5, 2026 · NCT06979362HeartShare: Combining Omics, Deep Phenotyping, and Electronic Health Records for Heart Failure Subtypes and Treatment Targets
- University of Pennsylvania, Philadelphia
RecruitingObservational studyHealthy volunteers welcome
Ages 30 and older · All sexes · Updated Sep 29, 2026 · NCT05873634Myocardial Mechanisms in Heart Failure With Preserved Ejection Fraction
- University of Pennsylvania, Philadelphia
RecruitingObservational studyHealthy volunteers welcome
Ages 30 and older · All sexes · Updated Sep 29, 2026 · NCT06517186A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF
- Research Site, Media
- Research Site, Philadelphia
- Research Site, Philadelphia
- and 2 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07761117Cholate Clearance in Fontan and Heart Failure
- Hospital of the University of Pennsylvania, Philadelphia
RecruitingObservational studyHealthy volunteers welcome
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07009132A Study to Determine the Efficacy and Safety of Finerenone and SGLT2i in Combination in Hospitalized Patients With Heart Failure (CONFIRMATION-HF)
- Philadelphia, PA Investigative Site CON-10068, Philadelphia
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT06024746A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients
- Philadelphia, PA Investigative Site 10068, Philadelphia
- Pittsburg, PA Investigative Site 1044, Pittsburgh
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT06008197Optimal Pediatric Heart Transplant Immunosuppression With MicroRNAs
- University of Pittsburgh, Pittsburgh
RecruitingObservational study
Up to age 18 · All sexes · Updated Aug 25, 2026 · NCT06532890Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure
- Jefferson Abington Hospital, Abington
- Penn Presbyterian Medical Center, Philadelphia
Recruiting
Ages 21 and older · All sexes · Updated Aug 25, 2026 · NCT05677100A Prospective Registry Study to Assess Real-world Patient Characteristics, Treatment Patterns, and Longitudinal Outcomes in Patients Receiving Mavacamten and Other Treatments for Symptomatic Obstructive Hypertrophic Cardiomyopathy (Obstructive-HCM)
- St. Luke's University Health Network, Bethlehem
- University Of Pittsburgh, Pittsburgh
- Geisinger Health System, Wilkes-Barre
RecruitingObservational study
Ages 18 and older · All sexes · Updated Aug 19, 2026 · NCT05489705A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity
- Penn State Hlth Holy Spirit Med Ctr, Camp Hill
- Chambersburg Hospital, Chambersburg
- Doylestown Heath cardiology, Doylestown
- and 2 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT07567001Alleviant ALLAY-HF Study
- Pinnacle Health Cardiovascular Institute, Harrisburg
Recruiting
Ages 40 and older · All sexes · Updated Aug 14, 2026 · NCT05685303PROACTIVE-HF-2 Trial Heart Failure NYHA Class II and III
- Penn State Health, Hershey
- UPMC, Pittsburgh
Recruiting
Ages 18 and older · All sexes · Updated Jun 29, 2026 · NCT05934487Quantifying New Heart Muscle Cells
- Children's Hospital of Philadelphia, Philadelphia
- Upmc Children'S Hospital of Pittsburgh, Pittsburgh
Recruiting
30 Days – 1 Year · All sexes · Updated Jun 15, 2026 · NCT06587165From ClinicalTrials.gov, data retrieved Nov 15, 2026. Each study sets its own eligibility; the study team decides who can join.