Home › Heart Failure › Pennsylvania › Philadelphia
Heart Failure clinical trials in Philadelphia, PA
31 studies for Heart Failure are looking for participants at sites in and around Philadelphia (within about 30 miles). Open a study to see who can join and how to contact the study team.
Myocardial Mechanisms in Heart Failure With Preserved Ejection Fraction
RecruitingObservational studyHealthy volunteers welcome
- University of Pennsylvania, Philadelphia
HeartShare: Combining Omics, Deep Phenotyping, and Electronic Health Records for Heart Failure Subtypes and Treatment Targets
RecruitingObservational studyHealthy volunteers welcome
- University of Pennsylvania, Philadelphia
A Study to Investigate CV Outcomes With Elecoglipron Compared With Placebo in Adult Participants With HFpEF or HFmrEF
RecruitingPhase 3
- Research Site, Philadelphia
- Research Site, Philadelphia
- Research Site, Media · 12 mi away
Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction
RecruitingPhase 3
- Hospital of the University of Pennsylvania (University of Pennsylvania School of Medicine), Philadelphia
Tezspire Cardiac Events PASS
RecruitingObservational study
- Healthcare Integrated Research Database (HIRD), Wilmington · 25 mi away
Cholate Clearance in Fontan and Heart Failure
RecruitingObservational studyHealthy volunteers welcome
- Hospital of the University of Pennsylvania, Philadelphia
Maridebart Cafraglutide in Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity
RecruitingPhase 3
- Abington Medical Specialists, Horsham · 16 mi away
Phase III Study Investigating Heart Failure and Cardiovascular Death With Baxdrostat in Combination With Dapagliflozin
RecruitingPhase 3
- Research Site, Philadelphia
- Research Site, Horsham · 16 mi away
- Research Site, West Chester · 24 mi away
Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function
RecruitingPhase 3
- Research Site, Philadelphia
- Research Site, Abington · 12 mi away
A Study to Determine the Efficacy and Safety of Finerenone and SGLT2i in Combination in Hospitalized Patients With Heart Failure (CONFIRMATION-HF)
RecruitingPhase 3
- Philadelphia, PA Investigative Site CON-10068, Philadelphia
A Study to Determine the Efficacy and Safety of Finerenone on Morbidity and Mortality Among Hospitalized Heart Failure Patients
RecruitingPhase 3
- Philadelphia, PA Investigative Site 10068, Philadelphia
Investigation of the BrioVAD System for the Treatment of Left Ventricular Heart Failure
Recruiting
- Thomas Jefferson University Hospital, Philadelphia
Safety and Effectiveness of Left Bundle Branch Area Pacing Versus Conventional Cardiac Resynchronization Therapy in Heart Failure
Recruiting
- Penn Presbyterian Medical Center, Philadelphia
Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)
RecruitingPhase 2/3
- Children's Hospital of Philadelphia (CHOP) ( Site 0004), Philadelphia
Diuretics Alone vs. Aortix Endovascular Device for Acute Heart Failure
Recruiting
- Penn Presbyterian Medical Center, Philadelphia
- Jefferson Abington Hospital, Abington · 12 mi away
NORM-HF Pivotal Study
Recruiting
- University of Pennsylvania, Philadelphia
Product Performance Report: Evaluate Long-term Reliability & Performance of Medtronic Marketed Cardiac Therapy Products
RecruitingObservational study
- Philadelphia, Philadelphia
LEVEL-2: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF-2
RecruitingPhase 3
- Tenax Investigational Site, Wynnewood · 7 mi away
A Research Study to Look at How Well NNC0487-0111 Works Compared to Placebo in People With Heart Failure and Obesity
RecruitingPhase 3
- Thomas Jefferson University, Philadelphia
Assessment of CCM in HF With Higher Ejection Fraction
Recruiting
- Penn Presbyterian Medical Center, Philadelphia
- Hospital of the University of Pennsylvania, Philadelphia
- Thomas Jefferson University Hospital, Philadelphia
- and 1 more
ELEVATE-HFpEF Clinical Study
Recruiting
- Lankenau Institute for Medical Research, Wynnewood · 7 mi away
Synchronized Diaphragmatic Stimulation in Symptomatic Heart Failure
Recruiting
- University of Pennsylvania, Philadelphia
The HEARTFELT Study
Recruiting
- Connect America, Bala-Cynwyd · 5 mi away
A Study to Learn More About How Safe Finerenone is, When it is Taken for a Longer Time With Standard Treatment, in Children and Young Adults With Heart Failure and Left Ventricular Systolic Dysfunction
RecruitingPhase 3
- Children's Hospital of Philadelphia - Cardiology, Philadelphia
- Nemours Children's Hospital - Delaware - Cardiology, Wilmington · 25 mi away
Quantifying New Heart Muscle Cells
Recruiting
- Children's Hospital of Philadelphia, Philadelphia
A Study to Learn More About How Well Finerenone Works, How Safe it is, and How it Moves Into, Through, and Out of the Body Compared to Placebo When Taken With Standard Treatment in Children With Heart Failure and Left Ventricular Systolic Dysfunction
RecruitingPhase 3
- Children's Hospital of Philadelphia - Cardiology, Philadelphia
- Nemours Children's Hospital - Delaware - Cardiology, Wilmington · 25 mi away
Trial to Evaluate Safety And Effectiveness of Mechanical Circulatory Support in Patients With Advancing Heart Failure
Recruiting
- University of Pennsylvania, Philadelphia
- Abington Memorial Hospital, Abington · 12 mi away
The EMPOWER Trial - The Carillon Mitral Contour System® in Treating Heart Failure With FMR
Recruiting
- University of Pennsylvania, Philadelphia
- Lankenau Institute of Medical Research, Wynnewood · 7 mi away
His-Bundle Corrective Pacing in Heart Failure
Recruiting
- University of Pennsylvania, Philadelphia
Left vs Left Randomized Clinical Trial
Recruiting
- University of Pennsylvania, Philadelphia
- Thomas Jefferson University Hospital, Philadelphia
Home-Based Exercise Program Using Mobile Technology After Left Ventricular Assist Device Implantation
Recruiting
- University of Pennsylvania, Philadelphia
About Heart Failure
Heart failure, or congestive heart failure (CHF), means the heart can't pump enough blood. Learn about the signs, symptoms, and causes.
More about Heart Failure on MedlinePlus
Heart Failure trials in other cities
- New York City, NY50 studies
- Boston, MA43 studies
- Dallas, TX42 studies
- Houston, TX36 studies
- Cleveland, OH33 studies
- Chicago, IL32 studies
- San Francisco, CA29 studies
- St. Louis, MO26 studies
- Durham, NC26 studies
- Kansas City, MO25 studies
- Atlanta, GA25 studies
- Baltimore, MD24 studies
Other studies in Philadelphia
- Cancer (all types)60 studies
- Breast Cancer56 studies
- Non-Small Cell Lung Cancer51 studies
- Metastatic Cancer46 studies
- Colorectal Cancer44 studies
- Ovarian Cancer44 studies
- Prostate Cancer44 studies
- Lung Cancer36 studies
- Acute Myeloid Leukemia34 studies
- Endometrial Cancer29 studies
- Head and Neck Squamous Cell Carcinoma26 studies
- Pancreatic Cancer26 studies
From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.