Melanoma clinical trials in California
70 studies for Melanoma are looking for participants at sites in California.
Cities in California
- Los Angeles34 studies
- San Francisco22 studies
- San Diego18 studies
- Orange14 studies
- Mountain View11 studies
- Baldwin Park10 studies
- Santa Monica8 studies
- Irvine6 studies
- Sacramento5 studies
- Stockton5 studies
- San Bernardino4 studies
- Oakland4 studies
- Santa Rosa4 studies
- Concord4 studies
- Fresno3 studies
- Roseville3 studies
- Santa Maria3 studies
- Arden-Arcade3 studies
- Elk Grove3 studies
- Newport Beach3 studies
- Glendale3 studies
- Fullerton3 studies
- San Jose3 studies
A Clinical Study of Intismeran Autogene (V940) and Pembrolizumab (MK-3475) in People With Melanoma (V940-012/INTerpath-012)
- UCSF Medical Center at Mission Bay ( Site 4044), San Francisco
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT06961006A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants With Advanced or Metastatic Melanoma (Harmony Head-to-Head)
- Providence Medical Foundation, Fullerton
- Cancer and Blood Specialty Clinic, Los Alamitos
- University of California Los Angeles, Los Angeles
- and 6 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06246916DESTINY-PANTUMOUR04
- Research Site, San Diego
RecruitingObservational study
Ages 18 to 130 · All sexes · Updated Sep 25, 2026 · NCT07124000A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
- City of Hope, Duarte
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06172478BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study
- Tower Cancer Research Foundation, Beverly Hills
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine
- The Angeles Clinic and Research Institute - West Los Angeles Office, Los Angeles
- and 4 more
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT05136196Pan-tumor MRD Study
- Los Angeles Cancer Network (LACN), Glendale
- Ventura County Hematology Oncology Specialists, Oxnard
- Medical Oncology Associates of San Diego (MOASD), San Diego
- and 2 more
RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT06605404A Study on How to Safely Guide Surgery for Melanoma and Similar Skin Tumors in Children Using Pathology and Genetic Information
- Kaiser Permanente-Oakland, Oakland
RecruitingPhase 2
Up to age 25 · All sexes · Updated Sep 24, 2026 · NCT07621614Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis
- Precision NextGen Oncology, Beverly Hills
- OPN Healthcare, Inc, Glendale
- University of Southern California, Los Angeles
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT06047379Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.
- City of Hope, Duarte
- USC Norris Comprehensive Cancer Center, Los Angeles
RecruitingPhase 3
Ages 18 to 70 · All sexes · Updated Sep 24, 2026 · NCT05727904Comparing the Effectiveness of Less Invasive Procedures With the Current Standard of Care for the Treatment of Older Adults With Early-Stage Melanoma
- Mission Hope Medical Oncology - Arroyo Grande, Arroyo Grande
- Mercy Cancer Center - Carmichael, Carmichael
- Mercy San Juan Medical Center, Carmichael
- and 14 more
RecruitingPhase 3
Ages 75 and older · All sexes · Updated Sep 24, 2026 · NCT07068074Intratumoral N17350 in Advanced Solid Tumors
- The Angeles Clinic and Research Institute, Los Angeles
- UCLA - Jonsson Comprehensive Cancer Center, Los Angeles
- Scripps Clinic Torrey Pines - La Jolla, San Diego
- and 1 more
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07339176BI-1808 as a Single Agent and With Pembrolizumab (KEYTRUDA® ) in Treatment of Advanced Malignancies(Keynote-D20)
- City of Hope National Medical Center, Duarte
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT04752826A Study of BMS-986504 Monotherapy and in Combination With Other Agents in Participants With Advanced and/or Metastatic Solid Tumors With Homozygous MTAP Deletion (MountainTAP-5)
- Local Institution - 0096, San Francisco
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT07492680A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases
- Providence Saint Joseph Medical Center/Disney Family Cancer Center, Burbank
- Epic Care-Dublin, Dublin
- Bay Area Breast Surgeons Inc, Emeryville
- and 9 more
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT04511013ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation
- University of California, San Diego, La Jolla
- Hoag Memorial Hospital Presbyterian, Newport Beach
- Redwood City, Redwood City
RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT05059444DOC1021 Dendritic Cell Immunotherapy for Refractory Melanoma
- City of Hope, Duarte
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT07288112Study of AMXT 1501 and DFMO in Combination With Standard Therapies in Advanced Solid Tumors
- University of California-San Diego, La Jolla
- START Los Angeles, Los Angeles
- University of California-San Fransisco, San Francisco
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 4, 2026 · NCT07287917Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
- Mission Hope Medical Oncology - Arroyo Grande, Arroyo Grande
- PCR Oncology, Arroyo Grande
- AIS Cancer Center at San Joaquin Community Hospital, Bakersfield
- and 20 more
RecruitingObservational studyHealthy volunteers welcome
Ages 40 to 75 · All sexes · Updated Sep 2, 2026 · NCT05334069A Study to Evaluate KIN-2787 in Participants With BRAF and/or NRAS Mutation Positive Solid Tumors
- The Angeles Clinic, Los Angeles
- UCLA, Los Angeles
- University of California San Diego, Moores Cancer Center, San Diego
- and 1 more
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT04913285A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and Potentially Beneficial When Used Alone or in Combination With Other Investigational Treatments Such as BNT327, for People With Advanced Malignant Tumors
- University of California San Francisco, San Francisco
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT07070232Immunotherapy in Combination With Prednisone and Sirolimus for Kidney Transplant Recipients With Unresectable or Metastatic Skin Cancer
- UC San Diego Moores Cancer Center, La Jolla
- Keck Medicine of USC Koreatown, Los Angeles
- Los Angeles General Medical Center, Los Angeles
- and 1 more
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Aug 31, 2026 · NCT05896839Positron Emission Tomography (PET) Guided Stereotactic Body Radiation Therapy for the Treatment of Oligoprogressive Non-small Cell Lung Cancer, Melanoma, and Renal Cell Carcinoma
- City of Hope Medical Center, Duarte
- City of Hope at Irvine Lennar, Irvine
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Aug 31, 2026 · NCT05830058Project: Every Child for Younger Patients With Cancer
- Kaiser Permanente Downey Medical Center, Downey
- City of Hope Comprehensive Cancer Center, Duarte
- Loma Linda University Medical Center, Loma Linda
- and 15 more
RecruitingObservational study
Up to age 25 · All sexes · Updated Aug 25, 2026 · NCT02402244Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors
- Children's Hospital Los Angeles, Los Angeles
- Children's Hospital of Orange County, Orange
- UCSF Medical Center-Mission Bay, San Francisco
RecruitingPhase 1/2
12 Months – 30 Years · All sexes · Updated Aug 25, 2026 · NCT04851119Binimetinib and Imatinib for Unresectable Stage III-IV KIT-Mutant Melanoma
- UC San Diego Moores Cancer Center, La Jolla
- University of California, San Francisco, San Francisco
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT04598009A Study of BMS-986340 as Monotherapy and as Combination Therapy in Participants With Advanced Solid Tumors
- Community Cancer Institute, Clovis
- USC/Norris Comprehensive Cancer Center, Los Angeles
- Hoag Memorial Hospital Presbyterian, Newport Beach
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT04895709Safety and Tolerability Study of GIM-531 in Advanced Solid Tumors
- Comprehensive Blood and Cancer Center, Bakersfield
- Providence Medical Foundation, Fullerton
- The Angeles Clinic and Research Institute, A Cedars-Sinai Affiliate, Los Angeles
- and 1 more
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Aug 14, 2026 · NCT06425926A Study of MGC026 in Participants With Advanced Solid Tumors
- The Angeles Clinic and Research Institute, Los Angeles
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Aug 11, 2026 · NCT06242470A Study of mRNA-4106 or mRNA-4200 Administered Alone or in Combination With Anti-Cancer Agents in Participants With Solid Tumors
- START Los Angeles, Los Angeles
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Aug 10, 2026 · NCT06880549A Study to Evaluate the Efficacy and Safety of Ifinatamab Deruxtecan (I-DXd) in Subjects With Recurrent or Metastatic Solid Tumors (IDeate-PanTumor02)
- Los Angeles Cancer Network, Los Angeles
- Pih Health Hematology Medical Oncology, Whittier
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT06330064Feasibility Study on the Effect of a Methionine-Reduced Diet on Serum Levels in Pts w/ Solid Tumors
- Chao Family Comprehensive Cancer Center, University of California, Irvine, Orange
RecruitingEarly phase 1
Ages 18 and older · All sexes · Updated Jul 31, 2026 · NCT07628634Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab (Keytruda®) in Subjects With Locally Advanced or Metastatic Solid Tumors (Hexavalent OX40 Agonist)
- City of Hope, Duarte
- Los Angeles Cancer Network, Glendale
- California Research Institute, Los Angeles
- and 3 more
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Jul 29, 2026 · NCT04198766Safety and Efficacy of OBX-115 in Advanced Solid Tumors
- The Angeles Clinic and Research Institute (Melanoma), Los Angeles
- USC Norris Comprehensive Cancer Center (Melanoma/NSCLC), Los Angeles
- Stanford Cancer Institute (Melanoma/NSCLC), Stanford
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Jul 16, 2026 · NCT06060613Repurposing Riluzole for Cancer-Related Cognitive Impairment: A Pilot Trial
- Chao Family Comprehensive Cancer Center, University of California Irvine, Orange
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jul 14, 2026 · NCT06580002Navigation Intervention for Adolescent and Young Adult Cancer Survivors
- KP Southern California - Department of Research & Evaluation, Pasadena
Recruiting
Ages 21 to 45 · All sexes · Updated Jul 6, 2026 · NCT07406087The Multicentre Selective Lymphadenectomy Trial - 3
- Cedars-Sinai Medical Centre, Los Angeles
Recruiting
Ages 18 and older · All sexes · Updated Jun 29, 2026 · NCT07049276A Study to Investigate the Efficacy and Safety of an Infusion of IOV-4001 in Adult Participants With Unresectable or Metastatic Melanoma or Stage III or IV Non-small-cell Lung Cancer
- The Angeles Clinic and Research Institute, Los Angeles
RecruitingPhase 1/2
Ages 18 to 70 · All sexes · Updated Jun 11, 2026 · NCT05361174MC1R-targeted Alpha-particle Monotherapy and Combination Therapy Trial With Nivolumab in Adults With Advanced Melanoma
- University of California Irvine, Orange
RecruitingPhase 1/2
Ages 18 to 90 · All sexes · Updated Jun 10, 2026 · NCT05655312Study of IDE196 in Patients With Solid Tumors Harboring GNAQ/11 Mutations or PRKC Fusions
- UCLA Medical Center, Los Angeles
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Jun 8, 2026 · NCT03947385DB-1311 in Combination With BNT327 or DB-1305 in Advanced/Metastatic Solid Tumors
- USA06-0, Los Angeles
- USA16-0, Los Angeles
RecruitingPhase 2
Ages 18 and older · All sexes · Updated May 22, 2026 · NCT06953089From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.