Melanoma clinical trials in Florida
55 studies for Melanoma are looking for participants at sites in Florida.
Cities in Florida
- Tampa19 studies
- Jacksonville16 studies
- Orlando15 studies
- Miami10 studies
- Hollywood5 studies
- St. Petersburg5 studies
- Lakeland5 studies
- Deltona5 studies
- Coral Springs5 studies
- Plantation4 studies
- Cape Coral3 studies
- Deerfield Beach3 studies
- Sarasota3 studies
A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants With Advanced or Metastatic Melanoma (Harmony Head-to-Head)
- Mayo Clinic Florida, Jacksonville
- Boca Raton Clinical Research (BRCR) Global, Tamarac
- H. Lee Moffitt Cancer Center, Tampa
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06246916DESTINY-PANTUMOUR04
- Research Site, Coral Springs
- Research Site, St. Petersburg
- Research Site, West Palm Beach
RecruitingObservational study
Ages 18 to 130 · All sexes · Updated Sep 25, 2026 · NCT07124000A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors
- AdventHealth Medical Group Oncology Research at Celebration, Kissimmee
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06172478BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study
- Mayo Clinic in Florida, Jacksonville
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT05136196Pan-tumor MRD Study
- Oncology & Hematology Associates of West Broward, Coral Springs
- Mid Florida Cancer Centers, Orange City
- Comprehensive Hematology Oncology (CHO), St. Petersburg
RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT06605404A Study on How to Safely Guide Surgery for Melanoma and Similar Skin Tumors in Children Using Pathology and Genetic Information
- Nemours Children's Clinic-Jacksonville, Jacksonville
- Nemours Children's Hospital, Orlando
- Nemours Children's Clinic - Pensacola, Pensacola
RecruitingPhase 2
Up to age 25 · All sexes · Updated Sep 24, 2026 · NCT07621614Safety and Efficacy of NEO212 in Patients With Astrocytoma IDH-mutant, Glioblastoma IDH-wildtype or Brain Metastasis
- MDR Core Network, Boynton Beach
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT06047379Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.
- Orlando Health Cancer Institute, Orlando
RecruitingPhase 3
Ages 18 to 70 · All sexes · Updated Sep 24, 2026 · NCT05727904Comparing the Effectiveness of Less Invasive Procedures With the Current Standard of Care for the Treatment of Older Adults With Early-Stage Melanoma
- Orlando Health Cancer Institute - Lake Mary, Lake Mary
- Lakeland Regional Health Hollis Cancer Center, Lakeland
- Health Central, Ocoee
- and 1 more
RecruitingPhase 3
Ages 75 and older · All sexes · Updated Sep 24, 2026 · NCT07068074Personalized Cancer Vaccine (PCV) Strategy in Patients With Solid Tumors and Molecular Residual Disease
- AdventHealth, Orlando
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT06529822Study of AU-007, A Monoclonal Antibody That Binds to IL-2 and Inhibits IL-2Rα Binding, in Patients With Unresectable Locally Advanced or Metastatic Cancer
- Sylvester Comprehensive Cancer Center - Miami, Miami
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT05267626Adjuvant Therapy Based on Pathologic Response After Neoadjuvant Encorafenib Binimetinib in Melanoma
- Moffitt Cancer Center, Tampa
RecruitingEarly phase 1
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT04741997A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases
- Orlando Health Cancer Institute, Orlando
- Moffitt Cancer Center-International Plaza, Tampa
- Moffitt Cancer Center - McKinley Campus, Tampa
- and 1 more
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT04511013ORACLE: Observation of ResiduAl Cancer With Liquid Biopsy Evaluation
- Memorial Healthcare System, Hollywood
- The Oncology Institute of Hope & Innovation, Lakeland
RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT05059444Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection
- Mount Sinai Comprehensive Cancer Center at Aventura, Aventura
- Schulze Family Foundation Cancer Clinic - Bonita Health Center, Bonita Springs
- Morton Plant Hospital, Clearwater
- and 11 more
RecruitingObservational studyHealthy volunteers welcome
Ages 40 to 75 · All sexes · Updated Sep 2, 2026 · NCT05334069A Study to Evaluate KIN-2787 in Participants With BRAF and/or NRAS Mutation Positive Solid Tumors
- Mayo Clinic - Florida, Jacksonville
- Sarah Cannon Research Institute - Florida Cancer Specialists, Orlando
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT04913285A Clinical Study to Test if an Investigational Treatment Called BNT326 is Safe and Potentially Beneficial When Used Alone or in Combination With Other Investigational Treatments Such as BNT327, for People With Advanced Malignant Tumors
- Florida Cancer Specialists, Sarasota
- Moffitt Cancer Center, Tampa
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT07070232Immunotherapy in Combination With Prednisone and Sirolimus for Kidney Transplant Recipients With Unresectable or Metastatic Skin Cancer
- UM Sylvester Comprehensive Cancer Center at Aventura, Aventura
- UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables
- UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach
- and 4 more
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Aug 31, 2026 · NCT05896839Project: Every Child for Younger Patients With Cancer
- Broward Health Medical Center, Fort Lauderdale
- Golisano Children's Hospital of Southwest Florida, Fort Myers
- UF Health Cancer Institute - Gainesville, Gainesville
- and 13 more
RecruitingObservational study
Up to age 25 · All sexes · Updated Aug 25, 2026 · NCT02402244Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors
- Mayo Clinic in Florida, Jacksonville
RecruitingPhase 1/2
Ages 16 and older · All sexes · Updated Aug 20, 2026 · NCT05269381A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors
- AdventHealth Celebration, Celebration
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Aug 11, 2026 · NCT05592626Nodal Radiation Therapy for Sentinel Lymph Node Positive Melanoma
- Baptist - MD Anderson Cancer Center, Jacksonville
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Aug 10, 2026 · NCT04594187The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and Improve Treatment Satisfaction in Cancer Patients Living in the Florida Panhandle and Surrounding Areas
- Mayo Clinic in Florida, Jacksonville
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jul 30, 2026 · NCT07285044Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab (Keytruda®) in Subjects With Locally Advanced or Metastatic Solid Tumors (Hexavalent OX40 Agonist)
- Clermont Oncology Center, Clermont
- Mid Florida Hematology and Oncology Center, Orange City
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Jul 29, 2026 · NCT04198766A Phase 1 of CTX-8371 in Patients With Advanced Malignancies
- Florida Cancer Specialists - Lake Nona, Orlando
- Florida Cancer Specialists - Sarasota, Sarasota
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Jul 28, 2026 · NCT06150664The Florida ASCENT Study
- University of Florida, Gainesville
Recruiting
Ages 18 to 100 · All sexes · Updated Jul 23, 2026 · NCT07042243Safety and Efficacy of OBX-115 in Advanced Solid Tumors
- Orlando Health Cancer Institute (Melanoma/NSCLC), Orlando
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Jul 16, 2026 · NCT06060613Integrated Cancer Repository for Cancer Research
- Florida Hospital Memorial Medical Center, Daytona Beach
- Florida Hospital DeLand, DeLand
- Florida Hospital FISH, Orange City
- and 2 more
RecruitingObservational studyHealthy volunteers welcome
Ages 19 to 110 · All sexes · Updated Jun 29, 2026 · NCT02012699Clinical Trial of CD40L-augmented TIL for Patients With Advanced Melanoma
- Moffitt Cancer Center, Tampa
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Jun 26, 2026 · NCT06961357A Study to Investigate the Efficacy and Safety of an Infusion of IOV-4001 in Adult Participants With Unresectable or Metastatic Melanoma or Stage III or IV Non-small-cell Lung Cancer
- Sylvester Comprehensive Cancer Center, Miami
- Orlando Health Cancer Institute, Orlando
- Moffitt Cancer Center, Tampa
RecruitingPhase 1/2
Ages 18 to 70 · All sexes · Updated Jun 11, 2026 · NCT05361174MEM-288 Oncolytic Virus Alone and in Combination With Standard of Care Therapy in Advanced Solid Tumors
- Moffitt Cancer Center, Tampa
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Jun 11, 2026 · NCT05076760MC1R-targeted Alpha-particle Monotherapy and Combination Therapy Trial With Nivolumab in Adults With Advanced Melanoma
- Mayo Clinic, Jacksonville
- University of Miami, Miami
- Sarasota Memorial Hospital, Sarasota
RecruitingPhase 1/2
Ages 18 to 90 · All sexes · Updated Jun 10, 2026 · NCT05655312Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) Program
- Mayo Clinic in Florida, Jacksonville
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Jun 9, 2026 · NCT06265285DB-1311 in Combination With BNT327 or DB-1305 in Advanced/Metastatic Solid Tumors
- USA08-0, Florida City
RecruitingPhase 2
Ages 18 and older · All sexes · Updated May 22, 2026 · NCT06953089Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS
- Moffitt Cancer Center, Tampa
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated May 15, 2026 · NCT05379985ACTengine® IMA203/IMA203CD8 as Monotherapy or in Combination With Nivolumab in Recurrent and/or Refractory Solid Tumors
- University of Miami Hospital and Clinics, Miami
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated May 13, 2026 · NCT03686124Neoadjuvant Darovasertib in Primary Uveal Melanoma
- Mayo Clinic Jacksonville, Jacksonville
- USF Health Eye Institute, Tampa
- Moffit Cancer Center, Tampa
RecruitingPhase 3
Ages 18 and older · All sexes · Updated May 6, 2026 · NCT07015190A Trial of LNS8801 With or Without Pembrolizumab in Patients With Refractory Melanoma
- Moffitt Cancer Center, Tampa
RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Apr 22, 2026 · NCT06624644A Study to Investigate the Safety and Efficacy of NST-628 Oral Tablets in Subjects With Solid Tumors
- Moffitt Cancer Center, Tampa
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Apr 20, 2026 · NCT06326411A Study of VET3-TGI in Patients With Solid Tumors
- University of Miami, Miami
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Apr 7, 2026 · NCT06444815From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.