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Melanoma clinical trials in Jacksonville, FL

16 studies for Melanoma are looking for participants at sites in and around Jacksonville (within about 30 miles). Open a study to see who can join and how to contact the study team.

A Study With Combinations of Anti-LAG-3 and Anti-PD-1 Antibodies in Adult Participants With Advanced or Metastatic Melanoma (Harmony Head-to-Head)

RecruitingPhase 3
  • Mayo Clinic Florida, Jacksonville
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06246916

BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

RecruitingPhase 2
  • Mayo Clinic in Florida, Jacksonville
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT05136196

A Study on How to Safely Guide Surgery for Melanoma and Similar Skin Tumors in Children Using Pathology and Genetic Information

RecruitingPhase 2
  • Nemours Children's Clinic-Jacksonville, Jacksonville
Up to age 25 · All sexes · Updated Sep 24, 2026 · NCT07621614

A Study to Evaluate KIN-2787 in Participants With BRAF and/or NRAS Mutation Positive Solid Tumors

RecruitingPhase 1
  • Mayo Clinic - Florida, Jacksonville
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT04913285

Project: Every Child for Younger Patients With Cancer

RecruitingObservational study
  • Nemours Children's Clinic-Jacksonville, Jacksonville
Up to age 25 · All sexes · Updated Aug 25, 2026 · NCT02402244

Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors

RecruitingPhase 1/2
  • Mayo Clinic in Florida, Jacksonville
Ages 16 and older · All sexes · Updated Aug 20, 2026 · NCT05269381

Nodal Radiation Therapy for Sentinel Lymph Node Positive Melanoma

RecruitingPhase 2
  • Baptist - MD Anderson Cancer Center, Jacksonville
Ages 18 and older · All sexes · Updated Aug 10, 2026 · NCT04594187

MC1R-targeted Alpha-particle Monotherapy and Combination Therapy Trial With Nivolumab in Adults With Advanced Melanoma

RecruitingPhase 1/2
  • Mayo Clinic, Jacksonville
Ages 18 to 90 · All sexes · Updated Jun 10, 2026 · NCT05655312

Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) Program

RecruitingPhase 2
  • Mayo Clinic in Florida, Jacksonville
Ages 18 and older · All sexes · Updated Jun 9, 2026 · NCT06265285

Neoadjuvant Darovasertib in Primary Uveal Melanoma

RecruitingPhase 3
  • Mayo Clinic Jacksonville, Jacksonville
Ages 18 and older · All sexes · Updated May 6, 2026 · NCT07015190

Tebentafusp Regimen Versus Investigator's Choice in Previously Treated Advanced Melanoma (TEBE-AM)

RecruitingPhase 3
  • Mayo Clinic Florida, Jacksonville
Ages 18 and older · All sexes · Updated Feb 25, 2026 · NCT05549297

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Jacksonville
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma

Recruiting
  • Baptist MD Anderson Cancer Center, Jacksonville
  • Mayo Clinic in Florida, Jacksonville
Ages 18 and older · All sexes · Updated Nov 27, 2024 · NCT03860883

About Melanoma

Melanoma is the most serious type of skin cancer. Most have a black or black-blue area. Learn the 'ABCDE' of what to watch for and treatment options.

More about Melanoma on MedlinePlus

Melanoma trials in other cities

Other studies in Jacksonville

From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.