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Melanoma clinical trials in Orlando, FL

15 studies for Melanoma are looking for participants at sites in and around Orlando (within about 30 miles). Open a study to see who can join and how to contact the study team.

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 2
  • AdventHealth Medical Group Oncology Research at Celebration, Kissimmee · 16 mi away
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06172478

A Study on How to Safely Guide Surgery for Melanoma and Similar Skin Tumors in Children Using Pathology and Genetic Information

RecruitingPhase 2
  • Nemours Children's Hospital, Orlando
Up to age 25 · All sexes · Updated Sep 24, 2026 · NCT07621614

Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.

RecruitingPhase 3
  • Orlando Health Cancer Institute, Orlando
Ages 18 to 70 · All sexes · Updated Sep 24, 2026 · NCT05727904

Comparing the Effectiveness of Less Invasive Procedures With the Current Standard of Care for the Treatment of Older Adults With Early-Stage Melanoma

RecruitingPhase 3
  • Orlando Health Cancer Institute, Orlando
  • Health Central, Ocoee · 10 mi away
Ages 75 and older · All sexes · Updated Sep 24, 2026 · NCT07068074

Personalized Cancer Vaccine (PCV) Strategy in Patients With Solid Tumors and Molecular Residual Disease

RecruitingPhase 1
  • AdventHealth, Orlando
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT06529822

A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases

RecruitingPhase 2
  • Orlando Health Cancer Institute, Orlando
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT04511013

A Study to Evaluate KIN-2787 in Participants With BRAF and/or NRAS Mutation Positive Solid Tumors

RecruitingPhase 1
  • Sarah Cannon Research Institute - Florida Cancer Specialists, Orlando
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT04913285

Project: Every Child for Younger Patients With Cancer

RecruitingObservational study
  • AdventHealth Orlando, Orlando
  • Arnold Palmer Hospital for Children, Orlando
  • Nemours Children's Hospital, Orlando
Up to age 25 · All sexes · Updated Aug 25, 2026 · NCT02402244

A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors

RecruitingPhase 1/2
  • AdventHealth Celebration, Celebration · 17 mi away
Ages 18 and older · All sexes · Updated Aug 11, 2026 · NCT05592626

Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab (Keytruda®) in Subjects With Locally Advanced or Metastatic Solid Tumors (Hexavalent OX40 Agonist)

RecruitingPhase 1/2
  • Clermont Oncology Center, Clermont · 24 mi away
Ages 18 and older · All sexes · Updated Jul 29, 2026 · NCT04198766

A Phase 1 of CTX-8371 in Patients With Advanced Malignancies

RecruitingPhase 1
  • Florida Cancer Specialists - Lake Nona, Orlando
Ages 18 and older · All sexes · Updated Jul 28, 2026 · NCT06150664

Safety and Efficacy of OBX-115 in Advanced Solid Tumors

RecruitingPhase 1/2
  • Orlando Health Cancer Institute (Melanoma/NSCLC), Orlando
Ages 18 and older · All sexes · Updated Jul 16, 2026 · NCT06060613

A Study to Investigate the Efficacy and Safety of an Infusion of IOV-4001 in Adult Participants With Unresectable or Metastatic Melanoma or Stage III or IV Non-small-cell Lung Cancer

RecruitingPhase 1/2
  • Orlando Health Cancer Institute, Orlando
Ages 18 to 70 · All sexes · Updated Jun 11, 2026 · NCT05361174

Tebentafusp Regimen Versus Investigator's Choice in Previously Treated Advanced Melanoma (TEBE-AM)

RecruitingPhase 3
  • Orlando Health Cancer Institute, Orlando
Ages 18 and older · All sexes · Updated Feb 25, 2026 · NCT05549297

A Phase 1/2a Study of DB-1311/BNT324 in Advanced/Metastatic Solid Tumors

RecruitingPhase 1/2
  • Research Site 137, Orlando
  • Research Site 118, Celebration · 17 mi away
Ages 18 and older · All sexes · Updated Nov 21, 2025 · NCT05914116

About Melanoma

Melanoma is the most serious type of skin cancer. Most have a black or black-blue area. Learn the 'ABCDE' of what to watch for and treatment options.

More about Melanoma on MedlinePlus

Melanoma trials in other cities

Other studies in Orlando

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.