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Non-Small Cell Lung Cancer clinical trials in Sacramento, CA

29 studies for Non-Small Cell Lung Cancer are looking for participants at sites in and around Sacramento (within about 30 miles). Open a study to see who can join and how to contact the study team.

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Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

RecruitingPhase 3
  • Kaiser Permanente Downtown Commons, Sacramento
  • Sutter Medical Center Sacramento, Sacramento
  • University of California Davis Comprehensive Cancer Center, Sacramento
  • and 1 more
Ages 18 and older · All sexes · Updated Oct 5, 2026 · NCT04267848

A Clinical Trial of Adjuvant Intismeran (V940) With or Without Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) in High-Risk Stage I Non-Small Cell Lung Cancer (V940-014)

RecruitingPhase 3
  • UC Davis Comprehensive Cancer Center ( Site 3204), Sacramento
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT07513376

Immunotherapy After Surgery for People Who Have No Remaining Cancer Cells After Standard Treatment for Early-Stage Non-Small Cell Lung Cancer, INSIGHT Trial

RecruitingPhase 3
  • Kaiser Permanente Downtown Commons, Sacramento
  • University of California Davis Comprehensive Cancer Center, Sacramento
  • Kaiser Permanente-South Sacramento, Sacramento
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06498635

A Study to Learn About the Study Medicine Called PF-08046054/SGN-PDL1V Versus Docetaxel in Adult Participants With Previously-Treated Programmed Cell Death Ligand 1 (PD-L1) Positive Non-Small-Cell Lung Cancer (NSCLC)

RecruitingPhase 3
  • Buhler Specialty Pavilion, Sacramento
  • Sutter Medical Center, Sacramento Infusion Center, Sacramento
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07144280

A Study to Compare the Efficacy of Nivolumab and Relatlimab Plus Chemotherapy vs Pembrolizumab Plus Chemotherapy for Stage IV/Recurrent Non-squamous Non-small Cell Lung Cancer With PD-L1 Expression ≥ 1%

RecruitingPhase 3
  • University of California Davis (UC Davis) Comprehensive Cancer Center, Sacramento
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT06561386

Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors

RecruitingPhase 1/2
  • UC Davis Comprehensive Cancer Center, Sacramento
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06128551

Osimertinib Alone or With Chemotherapy for EGFR-Mutant Lung Cancers

RecruitingPhase 2
  • UC Davis Cancer Center (Data Collection Only), Sacramento
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT04410796

A Study of Multiple Therapies in Biomarker-selected Participants With Resectable Stages IB-III Non-small Cell Lung Cancer (NSCLC)

RecruitingPhase 2
  • UC Davis Comprehensive Cancer Center, Sacramento
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT04302025

Sotorasib in Combination With Trastuzumab Deruxtecan for the Treatment of Locally Advanced and Metastatic Non-small Cell Lung Cancer With a KRAS G12C Mutation

RecruitingPhase 1/2
  • University of California Davis Comprehensive Cancer Center, Sacramento
Ages 18 and older · All sexes · Updated Sep 4, 2026 · NCT07012031

Risk-adapted, Proteomic-guided Systemic Therapy for Previously Untreated Advanced Non-small Cell Lung Cancer

RecruitingPhase 2
  • University of California Davis Comprehensive Cancer Center, Sacramento
Ages 18 and older · All sexes · Updated Aug 25, 2026 · NCT07250477

A Study of BH-30643 in Subjects With Locally Advanced or Metastatic NSCLC Harboring EGFR and/or HER2 Mutations

RecruitingPhase 1/2
  • University of California, Davis Comprehensive Cancer Center, Sacramento
Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT06706076

A Study of PF-08046054/SGN-PDL1V in Advanced Solid Tumors

RecruitingPhase 1
  • University of California Davis Comprehensive Cancer Center, Sacramento
  • University of California, Davis Medical Center, Sacramento
Ages 18 and older · All sexes · Updated Jul 22, 2026 · NCT05208762

LOcally ABLatIve ThErapy for OligopRogressive Lung And Thoracic MalignanciEs (OBLITERATE)

Recruiting
  • University of California, Davis, Sacramento
Ages 18 and older · All sexes · Updated Jul 8, 2026 · NCT06103682

Study of RAS(ON) Inhibitors in Patients With Advanced RAS-mutated NSCLC

RecruitingPhase 1/2
  • UC Davis, Davis Comprehensive Cancer Center, Sacramento
Ages 18 and older · All sexes · Updated Jun 30, 2026 · NCT06162221

LUNAR-2: TTFields With Pembrolizumab + Platinum-based Chemotherapy for Metastatic NSCLC

RecruitingPhase 3
  • Sutter Institute for Medical Research, Sacramento
Ages 18 and older · All sexes · Updated Jun 25, 2026 · NCT06216301

Comparing Combinations of Targeted Drugs for Advanced Non-Small Cell Lung Cancer That Has EGFR and MET Gene Changes (A Lung-MAP Treatment Trial)

RecruitingPhase 2
  • Kaiser Permanente Downtown Commons, Sacramento
  • Sutter Medical Center Sacramento, Sacramento
  • University of California Davis Comprehensive Cancer Center, Sacramento
Ages 18 and older · All sexes · Updated Jun 3, 2026 · NCT05642572

Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors

RecruitingPhase 1
  • University of California, Davis Comprehensive Cancer Center, Sacramento
Ages 18 and older · All sexes · Updated Jun 3, 2026 · NCT06040541

BBO-11818 in Adult Subjects With KRAS Mutant Cancer

RecruitingPhase 1
  • University of California Davis, Sacramento
Ages 18 and older · All sexes · Updated Jun 2, 2026 · NCT06917079

Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has Increased Copies of the MET Gene (An Expanded Lung-MAP Treatment Trial)

RecruitingPhase 2
  • Sutter Medical Center Sacramento, Sacramento
  • University of California Davis Comprehensive Cancer Center, Sacramento
Ages 18 and older · All sexes · Updated May 6, 2026 · NCT06116682

Adding the Immunotherapy Drug Cemiplimab to Usual Treatment for People With Advanced Non-Small Cell Lung Cancer Who Had Previous Treatment With Platinum Chemotherapy and Immunotherapy (An Expanded Lung-MAP Treatment Trial)

RecruitingPhase 2/3
  • Kaiser Permanente Downtown Commons, Sacramento
  • University of California Davis Comprehensive Cancer Center, Sacramento
Ages 18 and older · All sexes · Updated May 5, 2026 · NCT06616584

Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has a MET Exon 14 Skipping Gene Change (An Expanded Lung-MAP Treatment Trial)

RecruitingPhase 2
  • Sutter Medical Center Sacramento, Sacramento
  • University of California Davis Comprehensive Cancer Center, Sacramento
18 Minutes · All sexes · Updated May 5, 2026 · NCT06031688

A Study of DB-1310 in Advanced/Metastatic Solid Tumors

RecruitingPhase 1/2
  • University of California, Davis Comprehensive Cancer Center, Sacramento
Ages 18 and older · All sexes · Updated Apr 6, 2026 · NCT05785741

Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics

RecruitingObservational study
  • Kaiser Permanente Downtown Commons, Sacramento
  • Mercy Cancer Center - Sacramento, Sacramento
  • Kaiser Permanente-South Sacramento, Sacramento
  • and 1 more
Ages 18 and older · All sexes · Updated Mar 17, 2026 · NCT06418204

Fluorine-18-AlphaVBeta6-Binding Peptide Positron Emission Tomography in Metastatic Non-Small Cell Lung Cancer

RecruitingPhase 1
  • The University of California Davis Comprehensive Cancer Center, Sacramento
Ages 18 and older · All sexes · Updated Feb 27, 2026 · NCT05452005

Molecularly Targeted Radionuclide Therapy Via the Integrin Alphavbeta6

RecruitingPhase 1
  • The University of California Davis Comprehensive Cancer Center, Sacramento
Ages 18 and older · All sexes · Updated Feb 27, 2026 · NCT06228482

EZH2 Inhibitor, Tulmimetostat, and PD-1 Blockade for Treatment of Advanced Non-small Cell Lung Cancer

RecruitingPhase 1/2
  • VA Northern California Health Care System, Mather, CA, Sacramento
Ages 18 and older · All sexes · Updated Jan 27, 2026 · NCT05467748

A Study of the Oral EGFR Inhibitor PLB1004 in Non-Small Cell Lung Cancer

RecruitingPhase 1
  • University of California-Davis, Sacramento
Ages 18 and older · All sexes · Updated Apr 23, 2025 · NCT06046495

Non-Small Cell Lung Cancer trials in other cities

Other studies in Sacramento

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.