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Non-Small Cell Lung Cancer clinical trials in New Haven, CT

41 studies for Non-Small Cell Lung Cancer are looking for participants at sites in and around New Haven (within about 30 miles). Open a study to see who can join and how to contact the study team.

A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)

RecruitingPhase 3
  • Yale University School of Medicine ( Site 0201), New Haven
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT06623422

A Clinical Trial of Adjuvant Intismeran (V940) With or Without Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) in High-Risk Stage I Non-Small Cell Lung Cancer (V940-014)

RecruitingPhase 3
  • Smilow Cancer Center at Yale-New Haven ( Site 3253), New Haven
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07513376

Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

RecruitingPhase 3
  • Yale University, New Haven
  • Veterans Affairs Connecticut Healthcare System-West Haven Campus, West Haven · 3 mi away
  • Yale-New Haven Hospital North Haven Medical Center, North Haven · 7 mi away
  • and 2 more
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT04267848

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 2
  • Yale Cancer Center, New Haven
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06172478

A Study of JNJ-90301900 in Combination With Chemoradiation Followed by Consolidation Immunotherapy for Non-Small Cell Lung Cancer (NSCLC)

RecruitingPhase 2
  • Yale University, New Haven
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06667908

Neoadjuvant and Adjuvant Treatment in Resectable Non-small Cell Lung Cancer

RecruitingPhase 2
  • Research Site, New Haven
Ages 18 to 95 · All sexes · Updated Sep 23, 2026 · NCT05061550

Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors

RecruitingPhase 1
  • Yale University, Yale Cancer Center, New Haven
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT05983432

A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Locally Advanced or Metastatic Squamous Non-small Cell Lung Cancer (NSCLC)

RecruitingPhase 3
  • Research Site, West Haven · 3 mi away
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT06692738

Study of RMC-5127 in Patients With Advanced KRAS G12V-Mutant Solid Tumors

RecruitingPhase 1
  • Yale Cancer Center, New Haven
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07349537

A Phase 1 Study of IM-1617 in Participants With Advanced Cancer

RecruitingPhase 1
  • Yale Cancer Center, New Haven
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07578571

Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies

RecruitingPhase 1/2
  • Yale University School of Medicine - Yale Cancer Center, New Haven
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT05786924

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

RecruitingPhase 1/2
  • Yale Cancer Center, New Haven
Ages 12 and older · All sexes · Updated Sep 15, 2026 · NCT04585750

FiH Study to Investigate Safety, PK and Efficacy of the NaPi2b ADC TUB-040 in Patients With PROC or r/r Adenocarcinoma NSCLC

RecruitingPhase 1/2
  • Yale Cancer Center, New Haven
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT06303505

A Study of Multiple Therapies in Biomarker-selected Participants With Resectable Stages IB-III Non-small Cell Lung Cancer (NSCLC)

RecruitingPhase 2
  • Yale Cancer Center, New Haven
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT04302025

M0324 as Monotherapy and in Combination With Pembrolizumab or Chemotherapy in Participants With Selected Advanced Solid Tumors

RecruitingPhase 1
  • Yale Cancer Center, New Haven
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT07166601

A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

RecruitingPhase 3
  • Yale University School of Medicine, New Haven
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT06119581

A Study of a Selective ERBB2 Inhibitor (CGT4255), in Patients With Advanced Solid Tumors

RecruitingPhase 1
  • Yale Cancer Center, New Haven
Ages 18 and older · All sexes · Updated Sep 4, 2026 · NCT07361562

A Study to Learn About the Study Medicine Called PF-08046876 in People With Advanced Solid Tumors

RecruitingPhase 1
  • Smilow Cancer Hospital - Yale New Haven Health, New Haven
  • Yale - New Haven Hospital - Yale Cancer Center, New Haven
  • Smilow Cancer Hospital Phase 1 Unit, New Haven
Ages 18 and older · All sexes · Updated Sep 4, 2026 · NCT07090499

Open-label Study of BBO-8520 in Adult Subjects With KRASG12C Non-small Cell Lung Cancer

RecruitingPhase 1
  • Yale Cancer Center, New Haven
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT06343402

Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301)

RecruitingPhase 3
  • Yale University, Smillow Cancer Center, New Haven
Ages 18 and older · All sexes · Updated Aug 27, 2026 · NCT06881784

Phase III, Open-label Study of First-line Osimertinib With or Without Datopotamab Deruxtecan for EGFRm Locally Advanced or Metastatic Non-small Cell Lung Cancer

RecruitingPhase 3
  • Research Site, New Haven
Ages 18 and older · All sexes · Updated Aug 26, 2026 · NCT06350097

A Study of BH-30643 in Subjects With Locally Advanced or Metastatic NSCLC Harboring EGFR and/or HER2 Mutations

RecruitingPhase 1/2
  • Yale University - Cancer Center, New Haven
Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT06706076

Study of Zanzalintinib in Combination With Immuno-Oncology or Other Agents in Participants With Solid Tumors

RecruitingPhase 1
  • Exelixis Clinical Site #62, New Haven
Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT05176483

Study of STK-012 Alone and With Other Treatments in Patients With Advanced Lung Cancer and Other Cancers

RecruitingPhase 1/2
  • Yale New Haven Hospital, Yale Cancer Center, New Haven
Ages 18 and older · All sexes · Updated Jul 21, 2026 · NCT05098132

Dose-Deescalated 3-Fraction Stereotactic Body Radiotherapy For Centrally Located Lung Cancer

RecruitingPhase 1/2
  • Smilow Cancer Hospital, New Haven
  • Smilow Cancer Hospital - Hamden Care Center, Hamden · 6 mi away
  • Smilow Cancer Hospital Care Center - Guilford, Guilford · 13 mi away
Ages 18 and older · All sexes · Updated Jun 17, 2026 · NCT04210492

Study With ABBV-CLS-484 in Participants With Locally Advanced or Metastatic Tumors

RecruitingPhase 1
  • Yale University School of Medicine /ID# 225707, New Haven
Ages 18 and older · All sexes · Updated Jun 4, 2026 · NCT04777994

Comparing Combinations of Targeted Drugs for Advanced Non-Small Cell Lung Cancer That Has EGFR and MET Gene Changes (A Lung-MAP Treatment Trial)

RecruitingPhase 2
  • Yale University, New Haven
  • Smilow Cancer Hospital-Orange Care Center, Orange · 5 mi away
  • Yale-New Haven Hospital North Haven Medical Center, North Haven · 7 mi away
  • and 2 more
Ages 18 and older · All sexes · Updated Jun 3, 2026 · NCT05642572

Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors

RecruitingPhase 1
  • Smilow Cancer Hospital (Yale University), New Haven
Ages 18 and older · All sexes · Updated Jun 3, 2026 · NCT06040541

BBO-11818 in Adult Subjects With KRAS Mutant Cancer

RecruitingPhase 1
  • Yale University, New Haven
Ages 18 and older · All sexes · Updated Jun 2, 2026 · NCT06917079

Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has Increased Copies of the MET Gene (An Expanded Lung-MAP Treatment Trial)

RecruitingPhase 2
  • Yale University, New Haven
  • Yale-New Haven Hospital North Haven Medical Center, North Haven · 7 mi away
  • Smilow Cancer Hospital-Derby Care Center, Derby · 8 mi away
  • and 1 more
Ages 18 and older · All sexes · Updated May 6, 2026 · NCT06116682

Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has a MET Exon 14 Skipping Gene Change (An Expanded Lung-MAP Treatment Trial)

RecruitingPhase 2
  • Yale University, New Haven
  • Yale-New Haven Hospital North Haven Medical Center, North Haven · 7 mi away
  • Smilow Cancer Hospital-Derby Care Center, Derby · 8 mi away
  • and 1 more
18 Minutes · All sexes · Updated May 5, 2026 · NCT06031688

Adding the Immunotherapy Drug Cemiplimab to Usual Treatment for People With Advanced Non-Small Cell Lung Cancer Who Had Previous Treatment With Platinum Chemotherapy and Immunotherapy (An Expanded Lung-MAP Treatment Trial)

RecruitingPhase 2/3
  • Yale University, New Haven
  • Yale-New Haven Hospital North Haven Medical Center, North Haven · 7 mi away
  • Smilow Cancer Hospital-Derby Care Center, Derby · 8 mi away
  • and 1 more
Ages 18 and older · All sexes · Updated May 5, 2026 · NCT06616584

Study of PF-07248144 in Advanced or Metastatic Solid Tumors

RecruitingPhase 2
  • Smilow Cancer Hospital at Yale - New Haven, New Haven
  • Yale-New Haven Hospital- Yale Cancer Center, New Haven
  • Smilow Cancer Hospital Phase 1 Unit, New Haven
  • and 1 more
Ages 18 and older · All sexes · Updated Apr 16, 2026 · NCT04606446

Repositioning Immunotherapy in VetArans With Lung Cancer

RecruitingPhase 2
  • VA Connecticut Healthcare System West Haven Campus, West Haven, CT, West Haven · 3 mi away
Ages 18 and older · All sexes · Updated Mar 2, 2026 · NCT06275360

A Study of GV20-0251 Monotherapy and GV20-0251 in Combination With Pembrolizumab in Participants With Solid Tumor Malignancies

RecruitingPhase 1/2
  • Yale University, New Haven
Ages 18 and older · All sexes · Updated Feb 13, 2025 · NCT05669430

Phase 1a and Phase 2 Study for Safety, Preliminary Efficacy, PK and PD of ST-067

RecruitingPhase 1/2
  • Yale Cancer Center, New Haven
Ages 18 and older · All sexes · Updated Nov 15, 2024 · NCT04787042

Non-Small Cell Lung Cancer trials in other cities

Other studies in New Haven

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.