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Sickle Cell Disease clinical trials in Illinois
19 studies for Sickle Cell Disease are looking for participants at sites in Illinois.
Cities in Illinois
A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE)
- Uni of Illinois Hospital and HSC, Chicago
RecruitingPhase 3
Ages 12 to 100 · All sexes · Updated Sep 28, 2026 · NCT06439082A Phase 1b, Open-Label Study of DISC-3405 in Participants With Sickle Cell Disease (SCD)
- University of Illinois Hospital and Health Sciences System, Chicago
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07187973A Research Study Looking at Long-term Treatment With Etavopivat in People With Sickle Cell Disease or Thalassaemia
- Univer Of Illinois at Chicago, Chicago
RecruitingPhase 3
Ages 2 and older · All sexes · Updated Sep 18, 2026 · NCT06609226A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease
- Childrens Hospital of Chicago, Chicago
- Univer Of Illinois at Chicago, Chicago
RecruitingPhase 3
Ages 12 and older · All sexes · Updated Sep 17, 2026 · NCT06612268Tocilizumab for Acute Chest Syndrome
- University of Chicago, Chicago
RecruitingPhase 2
Ages 12 and older · All sexes · Updated Sep 15, 2026 · NCT05640271A Phase 2/3 Study of Osivelotor in Adult and Adolescent Participants With SCD
- University of Illinois at Chicago Clinical Research Center, Chicago
- University of Illinois Hospital and Health Sciences System - Investigational Drug Services (IDS), Chicago
- University of Illinois Hospital and Health Sciences System, Chicago
RecruitingPhase 2/3
Ages 12 and older · All sexes · Updated Aug 18, 2026 · NCT05431088A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease
- Local Institution - 0034, Chicago
RecruitingPhase 1/2Healthy volunteers welcome
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT06481306ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic Disorders
- Rush University Medical Center, Chicago
- Bleeding and Clotting Disorders Institute, Peoria
RecruitingObservational study
All ages · All sexes · Updated Aug 17, 2026 · NCT04398628Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive Crisis
- University of Illinois at Chicago, Chicago
RecruitingPhase 2
Ages 12 and older · All sexes · Updated Aug 14, 2026 · NCT06699849The Efficacy and Safety of Rilzabrutinib in Participants Aged 10 to 65 Years With Sickle-cell Disease
- University of Illinois-Chicago - College of Medicine- Site Number : 8400054, Chicago
RecruitingPhase 3
Ages 10 to 65 · All sexes · Updated Jul 29, 2026 · NCT06975865Study of HLA-Haploidentical Stem Cell Transplantation to Treat Clinically Aggressive Sickle Cell Disease
- University of Illinois at Chicago, Chicago
RecruitingPhase 2
Ages 16 to 60 · All sexes · Updated Jul 8, 2026 · NCT03121001Comparing the Effectiveness of Matched Related Donor Hematopoietic Stem Cell Transplantation to Disease Modifying Therapy in Pediatric Patients With Sickle Cell Disease
- Comer Children's Hospital (MRD-HCT), Chicago
RecruitingObservational study
Ages 3 to 20 · All sexes · Updated Jun 4, 2026 · NCT06941389Sickle Cell Clinical Research and Intervention Program
- Children's Hospital of Illinois at OSF-Saint Francis Medical Center, Peoria
RecruitingObservational study
All ages · All sexes · Updated Jun 4, 2026 · NCT02098863Targeting the Pathophysiology of Sickle Cell-Related Kidney Disease Using the SGLT2 Inhibitors, Empagliflozin
- University of Illinois Chicago, Sickle Cell Center, Chicago
RecruitingPhase 2
Ages 18 to 60 · All sexes · Updated May 19, 2026 · NCT07175051Delivering Patient-Facing Evidence-Based Guidelines Through mHealth to Adults With Sickle Cell Disease
- University of Illinois at Chicago, Chicago
Recruiting
Ages 18 and older · All sexes · Updated Mar 23, 2026 · NCT06919224Minimizing Toxicity in HLA-identical Sibling Donor Transplantation for Children With Sickle Cell Disease
- Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago
RecruitingPhase 2
Ages 2 to 25 · All sexes · Updated Mar 10, 2026 · NCT03587272Peer Support for Adolescents and Emerging Adults With Sickle Cell Pain
- Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago
Recruiting
Ages 16 to 30 · All sexes · Updated Jan 7, 2026 · NCT06374238Recruitment and Engagement in Care to Impact Practice Enhancement (RECIPE) for Sickle Cell Disease
- University of Illinois, Chicago
RecruitingObservational study
Ages 18 and older · All sexes · Updated Jun 22, 2025 · NCT06385886A Study of Nicotinamide With Oral Tetrahydrouridine and Decitabine to Treat High Risk Sickle Cell Disease
- University of Illinois at Chicago College of Medicine, Chicago
RecruitingPhase 1
Ages 18 and older · All sexes · Updated May 25, 2025 · NCT04055818From ClinicalTrials.gov, data retrieved Sep 30, 2026. Each study sets its own eligibility; the study team decides who can join.