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Sickle Cell Disease clinical trials in Chicago, IL
18 studies for Sickle Cell Disease are looking for participants at sites in and around Chicago (within about 30 miles). Open a study to see who can join and how to contact the study team.
Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →
A Study of Nicotinamide With Oral Tetrahydrouridine and Decitabine to Treat High Risk Sickle Cell Disease
RecruitingPhase 1
- University of Illinois at Chicago College of Medicine, Chicago
A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE)
RecruitingPhase 3
- Uni of Illinois Hospital and HSC, Chicago
A Phase 1b, Open-Label Study of DISC-3405 in Participants With Sickle Cell Disease (SCD)
RecruitingPhase 1
- University of Illinois Hospital and Health Sciences System, Chicago
A Research Study Looking at Long-term Treatment With Etavopivat in People With Sickle Cell Disease or Thalassaemia
RecruitingPhase 3
- Univer Of Illinois at Chicago, Chicago
A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease
RecruitingPhase 3
- Childrens Hospital of Chicago, Chicago
- Univer Of Illinois at Chicago, Chicago
Tocilizumab for Acute Chest Syndrome
RecruitingPhase 2
- University of Chicago, Chicago
A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease
RecruitingPhase 1/2Healthy volunteers welcome
- Local Institution - 0034, Chicago
A Phase 2/3 Study of Osivelotor in Adult and Adolescent Participants With SCD
RecruitingPhase 2/3
- University of Illinois at Chicago Clinical Research Center, Chicago
- University of Illinois Hospital and Health Sciences System - Investigational Drug Services (IDS), Chicago
- University of Illinois Hospital and Health Sciences System, Chicago
ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic Disorders
RecruitingObservational study
- Rush University Medical Center, Chicago
Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive Crisis
RecruitingPhase 2
- University of Illinois at Chicago, Chicago
The Efficacy and Safety of Rilzabrutinib in Participants Aged 10 to 65 Years With Sickle-cell Disease
RecruitingPhase 3
- University of Illinois-Chicago - College of Medicine- Site Number : 8400054, Chicago
Study of HLA-Haploidentical Stem Cell Transplantation to Treat Clinically Aggressive Sickle Cell Disease
RecruitingPhase 2
- University of Illinois at Chicago, Chicago
Comparing the Effectiveness of Matched Related Donor Hematopoietic Stem Cell Transplantation to Disease Modifying Therapy in Pediatric Patients With Sickle Cell Disease
RecruitingObservational study
- Comer Children's Hospital (MRD-HCT), Chicago
Targeting the Pathophysiology of Sickle Cell-Related Kidney Disease Using the SGLT2 Inhibitors, Empagliflozin
RecruitingPhase 2
- University of Illinois Chicago, Sickle Cell Center, Chicago
Delivering Patient-Facing Evidence-Based Guidelines Through mHealth to Adults With Sickle Cell Disease
Recruiting
- University of Illinois at Chicago, Chicago
Minimizing Toxicity in HLA-identical Sibling Donor Transplantation for Children With Sickle Cell Disease
RecruitingPhase 2
- Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago
Peer Support for Adolescents and Emerging Adults With Sickle Cell Pain
Recruiting
- Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago
Recruitment and Engagement in Care to Impact Practice Enhancement (RECIPE) for Sickle Cell Disease
RecruitingObservational study
- University of Illinois, Chicago
About Sickle Cell Disease
Sickle cell disease is a group of inherited disorders that affect your red blood cells. It can cause pain, anemia, and other problems. Learn about treatments.
More about Sickle Cell Disease on MedlinePlus
Sickle Cell Disease trials in other cities
- Atlanta, GA22 studies
- Washington, DC20 studies
- Memphis, TN18 studies
- Philadelphia, PA15 studies
- Birmingham, AL14 studies
- New York City, NY13 studies
- St. Louis, MO12 studies
- Durham, NC10 studies
- Cincinnati, OH10 studies
- Houston, TX10 studies
- Boston, MA10 studies
- Greenville, NC9 studies
Other studies in Chicago
- Non-Small Cell Lung Cancer61 studies
- Breast Cancer58 studies
- Cancer (all types)51 studies
- Metastatic Cancer45 studies
- Prostate Cancer45 studies
- Obesity41 studies
- Lung Cancer41 studies
- Ovarian Cancer36 studies
- Stroke34 studies
- Colorectal Cancer33 studies
- Heart Failure31 studies
- Overweight28 studies
From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.