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Crohn's Disease clinical trials in St. Louis, MO

19 studies for Crohn's Disease are looking for participants at sites in and around St. Louis (within about 30 miles). Open a study to see who can join and how to contact the study team.

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Study of Advanced Therapies for the Treatment of Adult Participants With Moderately to Severely Active Crohn's Disease or Ulcerative Colitis

RecruitingPhase 2
  • Specialists In Gastroenterology /ID# 283939, St Louis
Ages 18 to 75 · All sexes · Updated Oct 5, 2026 · NCT07697456

Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO

RecruitingPhase 1
  • Washington University School of Medicine, St Louis
  • Siteman Cancer Center-South County, St Louis
  • Siteman Cancer Center at Christian Hospital, St Louis
  • and 1 more
Ages 18 and older · All sexes · Updated Oct 5, 2026 · NCT03816345

A Study to Evaluate the Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderate to Severe Crohn's Disease (MK-7240-008)

RecruitingPhase 3
  • Washington University School of Medicine ( Site 5058), St Louis
Ages 16 to 80 · All sexes · Updated Oct 2, 2026 · NCT06430801

A Study of Vedolizumab in Adults With Ulcerative Colitis (UC) or Crohn's Disease (CD) in the Community Setting

RecruitingPhase 4
  • SSM Health Medical Group, Bridgeton · 15 mi away
Ages 18 to 80 · All sexes · Updated Sep 30, 2026 · NCT06581328

Study of Targeted Therapies for the Treatment of Adult Participants With Moderate to Severe Crohn's Disease

RecruitingPhase 2
  • Washington University /ID# 266938, St Louis
Ages 18 to 75 · All sexes · Updated Sep 25, 2026 · NCT06548542

Mirikizumab and Tirzepatide Administered in Adult Participants With Moderately to Severely Active Crohn's Disease and Obesity or Overweight

RecruitingPhase 3
  • Washington University School of Medicine, St Louis
Ages 18 to 70 · All sexes · Updated Sep 24, 2026 · NCT06937099

An Induction Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Crohn's Disease

RecruitingPhase 3
  • Washington University School of Medicine-Site Number: 8400075, St Louis
  • Gateway Gastroenterology-Site Number: 8400097, St Louis
Ages 16 to 80 · All sexes · Updated Sep 23, 2026 · NCT07184931

A Maintenance Study to Investigate the Efficacy and Safety of Duvakitug in Participants With Moderately to Severely Active Crohn's Disease

RecruitingPhase 3
  • Gateway Gastroenterology-Site Number: 8400097, St Louis
Ages 16 to 80 · All sexes · Updated Sep 23, 2026 · NCT07184944

A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulcerative Colitis or Crohn's Disease (SHINE-ON)

RecruitingPhase 3
  • Washington University School of Medicine, St Louis
Ages 2 to 19 · All sexes · Updated Sep 22, 2026 · NCT04844606

A Study of LY4395089 and Mirikizumab (LY3074828) Given Together and Mirikizumab (Alone) in Adults With Crohn's Disease

RecruitingPhase 2
  • KAD Clinical Research, St Louis
Ages 18 to 80 · All sexes · Updated Sep 22, 2026 · NCT07483099

A Phase 2 Study to Evaluate MORF-057 in Adults With Moderately to Severely Active Crohn's Disease

RecruitingPhase 2
  • SSM Health DePaul Hospital- St. Louis, Bridgeton · 15 mi away
Ages 18 to 85 · All sexes · Updated Sep 22, 2026 · NCT06226883

A Master Protocol (IIBD): A Study of Multiple Drugs in Adults With Ulcerative Colitis or Crohn's Disease

RecruitingPhase 2
  • KAD Clinical Research, St Louis
Ages 18 to 80 · All sexes · Updated Sep 22, 2026 · NCT07483073

A Study of Vedolizumab Intravenous (IV) and Adalimumab or Vedolizumab and Ustekinumab in Adults With Crohn's Disease

RecruitingPhase 4
  • Washington University School of Medicine, St Louis
Ages 18 to 70 · All sexes · Updated Sep 9, 2026 · NCT06045754

DB-3Q for the Treatment of Medically Refractory Crohn's Disease

RecruitingPhase 2
  • Washington University, St. Louis, St Louis
Ages 18 to 75 · All sexes · Updated Sep 1, 2026 · NCT07625293

Moving Beyond Inflammation as a Therapeutic Target for Crohn's Disease

RecruitingPhase 2
  • Washington University School of Medicine, St Louis
Ages 18 to 80 · All sexes · Updated Jun 5, 2026 · NCT06976853

A Study to Investigate Efficacy and Safety of SAR442970 in Patients With Crohn's Disease

RecruitingPhase 2
  • Investigational Site Number: 8400013, St Louis
Ages 18 to 75 · All sexes · Updated Mar 27, 2026 · NCT06958536

A Phase 2 Study to Evaluate Therapies for Inflammatory Bowel Disease

RecruitingPhase 2
  • Mirador Therapeutics Selected Site, Bridgeton · 15 mi away
Ages 18 to 80 · All sexes · Updated Mar 12, 2026 · NCT07113522

Treatment of Moderate to Severe Refractory Crohn's Disease

RecruitingPhase 1/2
  • Washington University in St. Louis, St Louis
Ages 18 to 65 · All sexes · Updated Dec 10, 2025 · NCT06721962

Development of a Novel Endoscopic Index and Patient-reported Outcome Measure for Clinical Trials in Participants With Permanent Ileostomy

RecruitingObservational study
  • Washington University in St Louis School of Medicine, St Louis
Ages 18 and older · All sexes · Updated Nov 12, 2025 · NCT06670638

About Crohn's Disease

Crohn's Disease can cause inflammation in any area from the mouth to the anus. Read about medicines, surgery or dietary management to treat symptoms.

More about Crohn's Disease on MedlinePlus

Crohn's Disease trials in other cities

Other studies in St. Louis

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.