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Cancer (all types) clinical trials in St. Louis, MO

46 studies for Cancer (all types) are looking for participants at sites in and around St. Louis (within about 30 miles). Open a study to see who can join and how to contact the study team.

Testing the Addition of Herceptin Hylecta or Phesgo to the Usual Chemotherapy for HER2 Positive Endometrial Serous Carcinoma or Carcinosarcoma

RecruitingPhase 3
  • Washington University School of Medicine, St Louis
  • Mercy Hospital South, St Louis
  • Mercy Hospital Saint Louis, St Louis
  • and 1 more
Ages 18 and older · Women · Updated Sep 28, 2026 · NCT05256225

A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue

RecruitingPhase 2/3
  • Cancer Care Specialists of Illinois - Cancer Care Center of O'Fallon, O'Fallon · 16 mi away
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06989437

Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell Manufacturing

RecruitingObservational study
  • Washington University, St Louis
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT04981119

Long-Term Follow-up Protocol for Participants Treated With Gene-Modified T Cells

RecruitingPhase 2/3
  • Siteman Cancer Center, St Louis
All ages · All sexes · Updated Sep 18, 2026 · NCT03435796

Collection of Tissue Samples for Cancer Research

RecruitingObservational study
  • Washington University - St. Louis, St Louis
2 Months · All sexes · Updated Sep 16, 2026 · NCT00900198

Replacing Invasive Cystoscopy With Urine Testing for Non-muscle Invasive Bladder Cancer Surveillance

RecruitingPhase 2
  • VA St.Louis Healthcare System, St Louis
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT05796375

A Phase I/IIa Study of AZD8205 Given Alone or Combined, in Participants With Advanced/Metastatic Solid Malignancies

RecruitingPhase 1/2
  • Research Site, St Louis
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT05123482

A Study to Investigate Safety and Effectiveness of Tacabrutideg (BGB-16673) in Combination With Other Agents in Participants With Relapsed or Refractory B-Cell Malignancies

RecruitingPhase 1/2
  • Washington University School of Medicine, St Louis
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT06634589

A Study to Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors

RecruitingPhase 1
  • Washington University School of Medicine, St Louis
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT06440005

A Phase 1/1b Study of IAM1363 in HER2 Cancers

RecruitingPhase 1
  • Washington University School of Medicine, St Louis
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT06253871

HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors

RecruitingPhase 1
  • Siteman Cancer Center at Washington University, St Louis
36 Months – 22 Years · All sexes · Updated Sep 4, 2026 · NCT03911388

A Longitudinal Multi-Omic Biomarker Profiling Study of Patients With Head & Neck Squamous Cell Carcinoma (HNSCC)

RecruitingObservational study
  • Washington University in St. Louis, St Louis
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT06163534

Project: Every Child for Younger Patients With Cancer

RecruitingObservational study
  • Cardinal Glennon Children's Medical Center, St Louis
  • Washington University School of Medicine, St Louis
  • Mercy Hospital Saint Louis, St Louis
Up to age 25 · All sexes · Updated Aug 25, 2026 · NCT02402244

A First-in-Human Study of KK2223 in Participants With Relapsed or Refractory T Cell Non-Hodgkin Lymphoma

RecruitingPhase 1
  • Washington University School of Medicine - Oncology Hospital - Public, St Louis
Ages 18 and older · All sexes · Updated Aug 21, 2026 · NCT07192471

Efficacy and Safety of Intravesical TARA-002 Compared With Investigator's Choice of Intravesical Chemotherapy in Participants With BCG-naïve High-grade Non-muscle Invasive Bladder Cancer

RecruitingPhase 3
  • Renown Regional Medical Center, St Louis
Ages 18 and older · All sexes · Updated Aug 21, 2026 · NCT07480356

FOG-001 in Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2
  • Washington University School of Medicine, St Louis
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT05919264

Testing Olaparib for One or Two Years, With or Without Bevacizumab, to Treat Ovarian Cancer

RecruitingPhase 3
  • Mercy Infusion Center - Chippewa, St Louis
  • Washington University School of Medicine, St Louis
  • Mercy Hospital South, St Louis
  • and 5 more
Ages 18 and older · All sexes · Updated Aug 7, 2026 · NCT06580314

A Study of PHN-012 in Patients With Advanced Solid Tumors

RecruitingPhase 1
  • PHN-012-001 Site, St Louis
Ages 18 and older · All sexes · Updated Aug 6, 2026 · NCT07127874

IDOV-Immune for Advanced Solid Tumors

RecruitingPhase 1
  • Washington University School of Medicine, St Louis
Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT06910657

A Study of ASP3082 in Adults With Advanced Solid Tumors

RecruitingPhase 1
  • Washington University School of Medicine, St Louis
Ages 18 and older · All sexes · Updated Jul 31, 2026 · NCT05382559

Relacorilant in Combination With Different Treatment Regimens in Patients With Gynecological Cancers

RecruitingPhase 2
  • 521, St Louis
Ages 18 and older · Women · Updated Jul 16, 2026 · NCT06906341

Study of mRNA-4359 Administered Alone and in Combination With Immune Checkpoint Blockade in Participants With Advanced Solid Tumors

RecruitingPhase 1/2
  • Washington University, St Louis
Ages 12 and older · All sexes · Updated Jul 14, 2026 · NCT05533697

A Phase 1 Study of BMS-986500 as Monotherapy or Combination Therapy in Advanced Solid Tumors

RecruitingPhase 1
  • Washington University School of Medicine, St Louis
Ages 18 and older · All sexes · Updated Jul 10, 2026 · NCT06997029

Registry Study for Radiation Therapy Outcomes

RecruitingObservational study
  • Mercy David C. Pratt Cancer Center, St Louis
All ages · All sexes · Updated Jul 10, 2026 · NCT01255748

CARE Tool Study Aim 3

Recruiting
  • Washington University School of Medicine, St Louis
  • Alton Memorial Hospital, Alton · 18 mi away
Ages 18 and older · All sexes · Updated Jul 8, 2026 · NCT07296887

First-in-Human Study of Tersolisib (STX-478) as Monotherapy and in Combination With Other Antineoplastic Agents in Participants With Advanced Solid Tumors

RecruitingPhase 1/2
  • Washington University, St Louis
Ages 18 and older · All sexes · Updated Jul 7, 2026 · NCT05768139

Predicting Response to Immunotherapy From Analysis of Live Tumor Biopsies (ELEPHAS-05)

RecruitingObservational study
  • Mercy Hospital - South, St Louis
  • Mercy Hospital -STL, St Louis
Ages 18 and older · All sexes · Updated Jun 29, 2026 · NCT07327489

Childhood Cancer Survivor Study

RecruitingObservational studyHealthy volunteers welcome
  • St. Louis Children's Hospital/The Washington University, St Louis
All ages · All sexes · Updated Jun 17, 2026 · NCT01120353

Preventing Liver Cancer Mortality Through Imaging With Ultrasound vs. MRI

Recruiting
  • St. Louis VA Medical Center John Cochran Division, St. Louis, MO, St Louis
Ages 18 to 75 · All sexes · Updated Jun 17, 2026 · NCT05486572

Patients At Risk for Sensory Screening (HPARSS) to Enhance Sensory Deficit Screening in Childhood Cancer Survivors

Recruiting
  • St. Louis Children's Hospital - Washington University School of Medicine, St Louis
Ages 7 to 17 · All sexes · Updated Jun 15, 2026 · NCT05582551

A Study to Evaluate the Safety and Efficacy of Mesothelin-Targeting Logic-gated CAR T, in Participants With Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression

RecruitingPhase 1/2
  • Washington University, St Louis
Ages 18 and older · All sexes · Updated Jun 12, 2026 · NCT06051695

A Study to Learn About Study Medicine ALTA3263 in Adults With Advanced Solid Tumors With KRAS Mutations

RecruitingPhase 1
  • Research Site, St Louis
Ages 18 and older · All sexes · Updated Jun 10, 2026 · NCT06835569

An AI-Generated, Personalized Question Prompt List Intervention for Patients With Hematologic Cancers

Recruiting
  • Washington University School of Medicine, St Louis
Ages 18 to 99 · All sexes · Updated Jun 1, 2026 · NCT07226934

A Study of Repotrectinib (TPX-0005) in Patients With Advanced Solid Tumors Harboring ALK, ROS1, or NTRK1-3 Rearrangements

RecruitingPhase 1/2
  • Washington University Infusion Center Pharmacy, St Louis
Ages 12 and older · All sexes · Updated May 27, 2026 · NCT03093116

Patient Position Monitoring System for Beam Gated Radiation Therapy of Malignancies of the Chest and Upper Abdomen

RecruitingObservational study
  • Washington University School of Medicine, St Louis
Ages 18 and older · All sexes · Updated May 22, 2026 · NCT07373496

Galleri® in the Medicare Population.

RecruitingHealthy volunteers welcome
  • Mercy Health St. Louis, St Louis
Ages 50 and older · All sexes · Updated May 22, 2026 · NCT05673018

A Study to Find a Suitable Dose of ASP5834 in Adults With Solid Tumors

RecruitingPhase 1
  • Washington University School of Medicine, St Louis
Ages 18 and older · All sexes · Updated May 18, 2026 · NCT07094204

TEMPUS ARIES: A Biobank Registry Platform Study in Oncology

RecruitingObservational study
  • Cancer Care Specialists of Illinois, O'Fallon · 16 mi away
Ages 18 to 99 · All sexes · Updated Feb 24, 2026 · NCT06207032

Cancer Care Companion

Recruiting
  • Washington University School of Medicine/Saint Louis Children's Hospital, St Louis
Ages 18 and older · All sexes · Updated Feb 6, 2026 · NCT07278778

GEMINI-NSCLC: NSCLC Biomarker Study

RecruitingObservational study
  • Mercy Clinic Oncology and Hematology - Sindelar Cancer Center, St Louis
  • Mercy Clinic Oncology and Hematology - David C. Pratt Cancer Center, St Louis
Ages 18 and older · All sexes · Updated Feb 5, 2026 · NCT05236114

Beat Childhood Cancer Specimen Banking and Data Registry

RecruitingObservational studyHealthy volunteers welcome
  • Cardinal Glennon Children's Hospital, St Louis
All ages · All sexes · Updated Feb 3, 2026 · NCT04715178

Phase 1 Study Evaluating the Safety and PK of ADU-1805 in Advanced Solid Tumors

RecruitingPhase 1
  • Washington University Medical Campus, St Louis
Ages 18 and older · All sexes · Updated Dec 17, 2025 · NCT05856981

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, St Louis
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

A Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated CAR T, in Participants With Solid Tumors That Express EGFR and Have Lost HLA-A*02 Expression

RecruitingPhase 1/2
  • Washington University, St Louis
Ages 18 and older · All sexes · Updated Sep 9, 2025 · NCT06682793

Tempus CRC Surveillance Study: A ctDNA Biomarker Profiling Study of Patients With CRC Using NGS Assays

RecruitingObservational study
  • Washington University School of Medicine, St Louis
  • Mercy Clinic Oncology and Hematology - Sindelar Cancer Center, St Louis
  • Mercy Clinic Oncology and Hematology - David C. Pratt Cancer Center, St Louis
Ages 18 and older · All sexes · Updated May 6, 2025 · NCT05234177

Melanoma Margins Trial-II: 1cm v 2cm Wide Surgical Excision Margins for AJCC Stage II Primary Cutaneous Melanoma

Recruiting
  • Washington University School of Medicine, St Louis
  • Siteman Cancer Centre, Barnes Jewish West County, Creve Coeur · 12 mi away
Ages 18 and older · All sexes · Updated Nov 27, 2024 · NCT03860883

About Cancer (all types)

If you or someone you love has been diagnosed with cancer, learn about diagnosis, treatment, risk factors, coping and much more.

More about Cancer (all types) on MedlinePlus

Cancer (all types) trials in other cities

Other studies in St. Louis

From ClinicalTrials.gov, data retrieved Sep 29, 2026. Each study sets its own eligibility; the study team decides who can join.