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Metastatic Cancer clinical trials in California
130 studies for Metastatic Cancer are looking for participants at sites in California.
Cities in California
- Los Angeles57 studies
- San Diego30 studies
- Baldwin Park30 studies
- San Francisco28 studies
- Mountain View25 studies
- Orange20 studies
- Santa Monica19 studies
- Irvine16 studies
- Sacramento16 studies
- Newport Beach10 studies
- Santa Rosa9 studies
- Carlsbad6 studies
- Torrance4 studies
- Burbank3 studies
- Santa Barbara3 studies
- Glendale3 studies
- Anaheim3 studies
- Huntington Beach3 studies
- Long Beach3 studies
- Concord3 studies
- Roseville3 studies
- Vista3 studies
- Vallejo3 studies
Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial
- PCR Oncology, Arroyo Grande
- Mercy Cancer Center - Carmichael, Carmichael
- Mercy San Juan Medical Center, Carmichael
- and 15 more
RecruitingPhase 2
All ages · All sexes · Updated Oct 2, 2026 · NCT05564377The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)
- University of San Diego Moores Cancer Center, La Jolla
- UCLA Jonsson Comprehensive Cancer Center, Los Angeles
- USC Norris Comprehensive Cancer Center, Los Angeles
RecruitingPhase 1/2
Ages 12 and older · All sexes · Updated Oct 2, 2026 · NCT04585750A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors
- City of Hope National Medical Center, Duarte
- University of California, San Diego (UCSD) - Moores Cancer Center, La Jolla
- UCLA Department of Medicine-Hematology/Oncology, Los Angeles
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06465069Atebimetinib + GnP as a First Line Treatment in Patients With Metastatic Pancreatic Adenocarcinoma
- City of Hope, Duarte
- University of California San Diego, San Diego
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT07562152Testing the Safety and Tolerability of the Anti-cancer Drugs Trastuzumab Deruxtecan and Neratinib for Cancers With Changes in the HER2 Gene
- City of Hope Comprehensive Cancer Center, Duarte
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine
- City of Hope at Irvine Lennar, Irvine
- and 2 more
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT05372614A Study of HC-7366 in Combination With Belzutifan (WELIREG™) in Patients With Renal Cell Carcinoma
- University of California San Diego Moores Cancer Center, La Jolla
- Cedars-Sinai Medical Center, Los Angeles
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06234605A Study With NKT3964 for Adults With Advanced/Metastatic Solid Tumors
- University of California - Los Angeles, Los Angeles
RecruitingPhase 1
Ages 19 and older · All sexes · Updated Oct 1, 2026 · NCT06586957Study of Orellanine in Metastatic Clear-Cell or Papillary Renal Cell Carcinoma
- University of California Irvine, Orange
- Stanford, Palo Alto
- University of California San Francisco, San Francisco
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT05287945Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors
- City of Hope Comprehensive Cancer Center, Duarte
- University of California Los Angeles, Los Angeles
- University of California San Diego Moores Cancer Center, San Diego
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06625775A First in Human Study of ALX2004 With Advanced or Metastatic Selected Solid Tumors
- ALX Center 9, La Jolla
- ALX Center 11, Santa Monica
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT07085091A Study of ASP3082 in Adults With Advanced Solid Tumors
- City of Hope National Medical Center, Duarte
- UCLA Santa Monica Hematology Oncology, Santa Monica
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT05382559Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors
- Cedars-Sinai Medical Center, Beverly Hills
- Norris Comprehensive Cancer Center, Los Angeles
- Stanford Cancer Center, Palo Alto
- and 2 more
RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT06943755Testing the Addition of an Anti-Cancer Drug, ZEN003694, to the Usual Chemotherapy Treatment (Capecitabine) for Metastatic or Unresectable Cancers
- UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine
- UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT05803382Symbiotic-GI-03: A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Metastatic Colorectal Cancer
- UCSF at Berkeley Outpatient Center, Berkeley
- Alta Bates Summit Medical Center-Herrick Campus Comprehensive Cancer Center, Berkeley
- UCSD Medical Center - Encinitas, Encinitas
- and 21 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07222800A Study of IDE892 as Monotherapy and Combination in MTAP-deleted Advanced Solid Tumors
- City of Hope Cancer Center-Duarte, Duarte
- Providence Medical Foundation, Santa Rosa
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07277413A Study of Repotrectinib in Pediatric and Young Adult Subjects Harboring ALK, ROS1, OR NTRK1-3 Alterations
- Children's Hospital Los Angeles, Los Angeles
- University of California at Los Angeles, Los Angeles
RecruitingPhase 1/2
Up to age 25 · All sexes · Updated Sep 25, 2026 · NCT04094610Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer
- Oncura Health - Anaheim, Anaheim
- Memorial Care Orange Coast Medical Center Attn, Fountain Valley
- MemorialCare Orange Coast Medical Center, Fountain Valley
- and 20 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07222566A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue
- UC San Diego Medical Center - Encinitas, Encinitas
- Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine
- UCI Health - Irvine, Irvine
- and 14 more
RecruitingPhase 2/3
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06989437A Phase III Study of Dato-DXd With or Without Durvalumab Compared With Investigator's Choice of Chemotherapy in Combination With Pembrolizumab in Patients With PD-L1 Positive Locally Recurrent Inoperable or Metastatic Triple-negative Breast Cancer (TROPION-Breast05)
- Research Site, Fountain Valley
- Research Site, Glendale
- Research Site, Sacramento
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06103864ASPEN-09-03: A Study of Evorpacept in Combination With Trastuzumab and Chemotherapy in Metastatic HER2-Positive Breast Cancer
- City of Hope, Duarte
- UC San Diego Moores Cancer Center, La Jolla
- UC Irvine Health - Chao Family Comprehensive Cancer Center, Orange
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07007559A Study of Zidesamtinib (NVL-520) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ROS1 Rearrangement (ARROS-1)
- UCI Medical Center, Orange
- Stanford Medicine, Palo Alto
- UC Davis Comprehensive Cancer Center, Sacramento
RecruitingPhase 1/2
Ages 12 and older · All sexes · Updated Sep 24, 2026 · NCT05118789A Study of KIVU-107 in Participants With Locally Advanced or Metastatic Solid Tumors
- Kivu Trial Site, Santa Monica
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT07229313Intratumoral N17350 in Advanced Solid Tumors
- The Angeles Clinic and Research Institute, Los Angeles
- UCLA - Jonsson Comprehensive Cancer Center, Los Angeles
- Scripps Clinic Torrey Pines - La Jolla, San Diego
- and 1 more
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07339176Safety and Preliminary Anti-Tumor Activity of TYRA-430 in Advanced Hepatocellular Carcinoma and Other Solid Tumors With Activating FGF/FGFR Pathway Aberrations
- USC Norris Comprehensive Cancer Center, Los Angeles
- UCSF Medical Center at Mount Zion, San Francisco
- Stanford Cancer Institute, Stanford
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT06915753A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract
- Chao Family Comprehensive Cancer Center and Ambulatory Care (CIACC) - Irvine, Irvine
- TRIO-US (Translational Research in Oncology-US), Los Angeles
- UCLA Hematology/Oncology - Santa Monica, Los Angeles
- and 4 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07218380Prospective External Control Cohort In Patients With Newly Diagnosed Advanced or Metastatic EGFR Mutant Non-Small Cell Lung Cancer
- Pacific Cancer Care, Monterey
- Torrance Memorial Physician Network-Cancer Care, Torrance
- John Muir Health, Walnut Creek
RecruitingObservational study
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07028489A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)
- Community Cancer Institute, Clovis
- City of Hope, Duarte
- Epic Care - Emeryville, Emeryville
- and 19 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07174336Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors
- UC IRVINE Health, Orange
- UC Davis Comprehensive Cancer Center, Sacramento
- Stanford Cancer Institute, Stanford
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06128551A Study of LY4257496 in Participants With Cancer (OMNIRAY)
- City of Hope, Duarte
- University of California, Los Angeles (UCLA), Santa Monica
- Stanford University Medical Center, Stanford
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07114601EIK1005-002: A Clinical Research Study Evaluating EIK1005, a Werner Helicase Inhibitor, as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced Solid Tumors Including Microsatellite Instability High (MSI-H) Tumors
- California Research Institute (CRI), Los Angeles
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07262619SLV-154 Treatment of Advanced Cancers
- Hoag Memorial Hospital Presbyterian, Newport Beach
RecruitingPhase 1
Ages 12 and older · All sexes · Updated Sep 22, 2026 · NCT06771219A Three-Part Phase 3 Study of Sofetabart Mipitecan in Participants With Platinum-Resistant (Part A) and Platinum-Sensitive (Parts B and C) Ovarian Cancer
- Roy and Patricia Disney Family Cancer Center - Providence Saint Joseph Medical Center, Burbank
- City of Hope, Duarte, Duarte
- City of Hope Lennar, Irvine
- and 6 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07213804AMG 436 as Monotherapy and Combination Therapy in Participants With MSI-H/dMMR Solid Tumors
- City of Hope Orange County Lennar Foundation Cancer Center, Irvine
- Hoag Memorial Hospital Presbyterian, Newport Beach
RecruitingPhase 1
Ages 18 to 99 · All sexes · Updated Sep 21, 2026 · NCT07403721Symbiotic-GU-08: A Study to Learn About the Medicine Called PF-08634404 Dosed Alone and in Combination With Other Anticancer Therapies in Adults With Locally Advanced or Metastatic Renal Cell Cancer
- City of Hope (City of Hope National Medical Center, City of Hope Medical Center), Duarte
- City of Hope Investigational Drug Services (IDS), Duarte
- UC San Diego Medical Center - Encinitas, Encinitas
- and 13 more
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07227415A Clinical Study of Ifinatamab Deruxtecan Based Treatment Combinations or as Monotherapy to Treat Metastatic Castrate Resistant Prostate Cancer (mCRPC) (MK-2400-01A/IDeate-Prostate02)
- UCLA Hematology & Oncology ( Site 0003), Los Angeles
- University of California-Irvine Medical Center ( Site 0016), Orange
- UCSF Medical Center at Mission Bay ( Site 0034), San Francisco
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT06863272CREO - Microwave Ablation Feasibility Study
- Cedars Sinai, Los Angeles
Recruiting
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT07817147Molecularly Targeted Theranostic Approach for the Detection and Treatment of Metastatic Carcinomas
- The University of California Davis Comprehensive Cancer Center, Sacramento
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT06389123A Study of KK2269 in Adult Participants With Solid Tumors
- City Of Hope National Medical Center, Duarte
- Hoag Memorial Hospital Presbyterian, Newport Beach
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT06266299CR-001 in Adult Participants With Locally Advanced or Metastatic Solid Tumors
- Clinical Study Site, Los Angeles
RecruitingPhase 1/2
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT07335497Trial Comparing LATTICE Radiotherapy vs Moderately Dose-escalated Palliative Radiation for Patients With Metastases.
- Stanford University, Palo Alto
RecruitingPhase 2
Ages 12 and older · All sexes · Updated Sep 9, 2026 · NCT07594431From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.