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Oral Cancer clinical trials in Sioux Falls, SD

4 studies for Oral Cancer are looking for participants at sites in and around Sioux Falls (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment

RecruitingPhase 3
  • Sanford Cancer Center Oncology Clinic, Sioux Falls
  • Avera Cancer Institute, Sioux Falls
  • Sanford USD Medical Center - Sioux Falls, Sioux Falls
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06589804

BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

RecruitingPhase 2
  • Sanford Cancer Center Oncology Clinic, Sioux Falls
  • Sanford USD Medical Center - Sioux Falls, Sioux Falls
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT05136196

Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery

RecruitingPhase 2
  • Sanford Cancer Center Oncology Clinic, Sioux Falls
  • Avera Cancer Institute, Sioux Falls
  • Sanford USD Medical Center - Sioux Falls, Sioux Falls
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT02734537

Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity Cancer

RecruitingPhase 2/3
  • Avera Cancer Institute, Sioux Falls
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT04333537

About Oral Cancer

Oral cancer can form in the mouth or throat but usually begins in the tongue and floor of the mouth. Read about the common oral cancer symptoms.

More about Oral Cancer on MedlinePlus

Oral Cancer trials in other cities

Other studies in Sioux Falls

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.