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Pancreatic Cancer clinical trials in St. Louis, MO

33 studies for Pancreatic Cancer are looking for participants at sites in and around St. Louis (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

The Vanguard Study: Testing a New Way to Screen for Cancer

RecruitingHealthy volunteers welcome
  • Washington University School of Medicine, St Louis
Ages 45 to 75 · All sexes · Updated Oct 5, 2026 · NCT06995898

Testing the Safety and Tolerability of the Anti-cancer Drugs Trastuzumab Deruxtecan and Neratinib for Cancers With Changes in the HER2 Gene

RecruitingPhase 1
  • Washington University School of Medicine, St Louis
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT05372614

A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors

RecruitingPhase 1
  • Washington University School of Medicine in St. Louis, St Louis
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06465069

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 2
  • Washington University, School of Medicine, St Louis
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06172478

A Study of PHN-012 in Patients With Advanced Solid Tumors

RecruitingPhase 1
  • PHN-012-001 Site, St Louis
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT07127874

Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell Manufacturing

RecruitingObservational study
  • Washington University, St Louis
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT04981119

A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue

RecruitingPhase 2/3
  • Cancer Care Specialists of Illinois - Cancer Care Center of O'Fallon, O'Fallon · 16 mi away
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06989437

A Study to Evaluate the Effectiveness and Safety of Setidegrasib, Given With Either mFOLFIRINOX or NALIRIFOX Chemotherapies, in People With Pancreatic Cancer

RecruitingPhase 3
  • The Alvin J. Siteman Cancer Center - Center for Advanced Med, St Louis
  • Mercy David C. Pratt Cancer Center - St. - Mercy Research - David C. Pratt Cancer Center, St Louis
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07409272

A Study of Nuzefatide Pevedotin (BT5528) in Patients With Metastatic Pancreatic Ductal Adenocarcinoma (PDAC)

RecruitingPhase 2
  • Siteman Cancer Center (Washington University School of Medicine), St Louis
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT07450859

A Study Evaluating a New Radiation Treatment Workflow (NGDS)

Recruiting
  • Siteman Cancer Center Washington University, St Louis
Ages 21 and older · All sexes · Updated Sep 17, 2026 · NCT07824583

Radiotherapy in Combination With TTI-101 in Borderline Resectable and Locally Advanced Pancreatic Ductal Adenocarcinoma

RecruitingPhase 1
  • Washington University School of Medicine, St Louis
Ages 18 and older · All sexes · Updated Sep 11, 2026 · NCT06141031

Biospecimen Collection to Identify Gene Mutations for High Risk Pancreatic Cancer in Pediatric Patients, INSPPIRE 2 Study

RecruitingObservational study
  • Washington University School of Medicine, St Louis
Up to age 17 · All sexes · Updated Sep 11, 2026 · NCT06651580

Stereotactic Adaptive Radiation Therapy of Borderline Resectable Pancreatic Cancer an Individualized Approach

Recruiting
  • Washington University, St. Louis, St Louis
Ages 18 and older · All sexes · Updated Sep 10, 2026 · NCT05764720

A Study to Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors

RecruitingPhase 1
  • Washington University School of Medicine, St Louis
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT06440005

Comparing the Clinical Impact of Pancreatic Cyst Surveillance Programs and Associated Biomarkers

RecruitingObservational study
  • Washington University School of Medicine, St Louis
  • Missouri Baptist Medical Center, St Louis
  • Cancer Care Center of O'Fallon, O'Fallon · 16 mi away
  • and 1 more
Ages 50 to 75 · All sexes · Updated Sep 4, 2026 · NCT04239573

A Phase 2 Study of VS-7375 in Patients With KRAS G12D-Mutated Pancreatic Cancer

RecruitingPhase 2
  • Washington University, St Louis
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT07644559

Testing the Addition of Sunitinib Malate to Lutetium Lu 177 Dotatate (Lutathera) in Pancreatic Neuroendocrine Tumors

RecruitingPhase 1
  • Washington University School of Medicine, St Louis
  • Siteman Cancer Center-South County, St Louis
  • Siteman Cancer Center at Christian Hospital, St Louis
  • and 2 more
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT05687123

Testing Higher Dose Radiation Therapy for Locally Advanced Pancreatic Cancer

RecruitingPhase 3
  • Cancer Care Center of O'Fallon, O'Fallon · 16 mi away
  • HSHS Saint Elizabeth's Hospital, O'Fallon · 16 mi away
Ages 18 and older · All sexes · Updated Aug 25, 2026 · NCT06958328

MicroEnvironment Tumor Effects of Radiotherapy - Comprehensive Radiobiology Assessment TRial

Recruiting
  • Washington University School of Medicine, St Louis
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT05975593

IDOV-Immune for Advanced Solid Tumors

RecruitingPhase 1
  • Washington University School of Medicine, St Louis
Ages 18 and older · All sexes · Updated Aug 5, 2026 · NCT06910657

Study of Orally Administered MOMA-313 in Participants With Advanced or Metastatic Solid Tumors

RecruitingPhase 1
  • Investigative Site #110, St Louis
Ages 18 and older · All sexes · Updated Jul 23, 2026 · NCT06545942

A Study to Evaluate the Safety and Efficacy of Mesothelin-Targeting Logic-gated CAR T, in Participants With Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression

RecruitingPhase 1/2
  • Washington University, St Louis
Ages 18 and older · All sexes · Updated Jun 12, 2026 · NCT06051695

A Study to Learn About Study Medicine ALTA3263 in Adults With Advanced Solid Tumors With KRAS Mutations

RecruitingPhase 1
  • Research Site, St Louis
Ages 18 and older · All sexes · Updated Jun 10, 2026 · NCT06835569

Studying Chemotherapy With or Without Panitumumab for Unresectable, Locally Advanced, or Metastatic Pancreatic Cancer Without KRAS Mutations

RecruitingPhase 3
  • Missouri Baptist Medical Center, St Louis
  • BJC Outpatient Center at Sunset Hills, Sunset Hills · 13 mi away
  • Cancer Care Center of O'Fallon, O'Fallon · 16 mi away
  • and 1 more
Ages 18 and older · All sexes · Updated May 22, 2026 · NCT06998940

MK2 Inhibitor in Combination With mFOLFIRINOX for Untreated Metastatic Pancreatic Ductal Adenocarcinoma

RecruitingPhase 1
  • Washington University School of Medicine, St Louis
Ages 18 and older · All sexes · Updated Apr 30, 2026 · NCT06648434

A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors

RecruitingPhase 1/2
  • Washington University School of Medicine, St Louis
Ages 18 and older · All sexes · Updated Apr 22, 2026 · NCT07020221

Stereotactic Body Radiotherapy Plus FAK and RAF/MEK Inhibition in Advanced Pancreatic Adenocarcinoma

RecruitingPhase 2
  • Washington University School of Medicine, St Louis
Ages 18 and older · All sexes · Updated Apr 15, 2026 · NCT07126158

Lanreotide Versus Placebo Before Surgery to Prevent a Surgical Complication Called a Pancreatic Fistula

RecruitingPhase 3
  • Missouri Baptist Medical Center, St Louis
  • BJC Outpatient Center at Sunset Hills, Sunset Hills · 13 mi away
Ages 18 and older · All sexes · Updated Mar 31, 2026 · NCT06807437

Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors

RecruitingPhase 1/2
  • Washington University, St Louis
Ages 18 and older · All sexes · Updated Feb 18, 2026 · NCT07030257

A Phase II Nationwide, Fully Decentralized, Telemedicine Study of Pemigatinib in Adult Patients With Advanced or Metastatic Pancreatic Cancer With FGFR Genetic Alterations

RecruitingPhase 2
  • Ohio State University-Telemedicine, St Louis
Ages 18 and older · All sexes · Updated Feb 17, 2026 · NCT06906562

JAB-23E73 in Adult Participants With Advanced Solid Tumors With KRAS Alteration

RecruitingPhase 1/2
  • Washington University, St Louis
Ages 18 and older · All sexes · Updated Jan 16, 2026 · NCT06973564

LOTUS-CC: An Observational Research Study to Uncover Subtypes of Cancer Cachexia

RecruitingObservational study
  • Mercy Hospital South, St Louis
  • Missouri Baptist Medical Center, St Louis
  • BJC Outpatient Center at Sunset Hills, Sunset Hills · 13 mi away
  • and 3 more
Ages 18 and older · All sexes · Updated Jan 9, 2026 · NCT06073431

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, St Louis
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

About Pancreatic Cancer

The pancreas is a gland behind your stomach that produces insulin. Pancreatic cancer is hard to catch early. Find out about risk factors and symptoms.

More about Pancreatic Cancer on MedlinePlus

Pancreatic Cancer trials in other cities

Other studies in St. Louis

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.