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Prostate Cancer clinical trials in California

156 studies for Prostate Cancer are looking for participants at sites in California.

Cities in California

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

  • University of San Diego Moores Cancer Center, La Jolla
  • UCLA Jonsson Comprehensive Cancer Center, Los Angeles
  • USC Norris Comprehensive Cancer Center, Los Angeles
RecruitingPhase 1/2
Ages 12 and older · All sexes · Updated Oct 2, 2026 · NCT04585750

Testing the Addition of Docetaxel (Chemotherapy) to the Usual Treatment (Hormonal Therapy and Apalutamide) for Metastatic Prostate Cancer, ASPIRE Trial

  • Kaiser Permanente Dublin, Dublin
  • Kaiser Permanente-Fremont, Fremont
  • Kaiser Permanente Fresno Orchard Plaza, Fresno
  • and 18 more
RecruitingPhase 3
Ages 18 and older · Men · Updated Oct 2, 2026 · NCT06931340

Testing Different Dosing Schedules of the Anti-cancer Drug, Lutetium 177Lu PSMA RLT and Its Effect on Patients With Advanced Prostate Cancer, RECIPROCAL Trial

  • AIS Cancer Center at San Joaquin Community Hospital, Bakersfield
  • UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine
  • City of Hope at Irvine Lennar, Irvine
  • and 5 more
RecruitingPhase 3
Ages 18 and older · Men · Updated Oct 2, 2026 · NCT07200830

Distance-Based Exercise to Preserve Function and Prevent Disability

  • Kaiser Permanente Dublin, Dublin
  • Kaiser Permanente-Fremont, Fremont
  • Kaiser Permanente Fresno Orchard Plaza, Fresno
  • and 10 more
Recruiting
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT07059884

A Study of LY4052031 in Participants With Advanced or Metastatic Urothelial Cancer or Other Solid Tumors

  • City of Hope National Medical Center, Duarte
  • University of California, San Diego (UCSD) - Moores Cancer Center, La Jolla
  • UCLA Department of Medicine-Hematology/Oncology, Los Angeles
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06465069

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

  • Mission Hope Medical Oncology - Arroyo Grande, Arroyo Grande
  • PCR Oncology, Arroyo Grande
  • AIS Cancer Center at San Joaquin Community Hospital, Bakersfield
  • and 20 more
RecruitingObservational studyHealthy volunteers welcome
Ages 40 to 75 · All sexes · Updated Oct 2, 2026 · NCT05334069

Targeted Treatment for Metastatic Prostate Cancer, The PREDICT Trial

  • Enloe Medical Center, Chico
  • UC San Diego Health System - Encinitas, Encinitas
  • UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine
  • and 4 more
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06632977

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

  • City of Hope, Duarte
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06172478

Study of AR Suppression With Carotuximab in Metastatic, Castration-Resistant Prostate Canc

  • City of Hope, Duarte
  • Cedars-Sinai Medical Center, Los Angeles
RecruitingPhase 2
Ages 18 and older · Men · Updated Sep 30, 2026 · NCT05534646

Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors

  • Keck Medicine of USC Koreatown, Los Angeles
  • Los Angeles General Medical Center, Los Angeles
  • USC / Norris Comprehensive Cancer Center, Los Angeles
  • and 1 more
RecruitingPhase 2
Ages 18 and older · All sexes · Updated Sep 30, 2026 · NCT03866382

An Investigational Scan (Flotufolastat F 18 PET/CT) for Detecting Residual or Recurrent Disease in Patients Who Completed Focal Therapy for Prostate Cancer.

  • UCLA / Jonsson Comprehensive Cancer Center, Los Angeles
RecruitingPhase 2
Ages 18 to 90 · Men · Updated Sep 29, 2026 · NCT07185165

Precision-Based Genomics in Prostate Cancer

  • University of California San Diego, La Jolla
  • University of California San Francisco, San Francisco
RecruitingObservational study
Ages 18 to 120 · Men · Updated Sep 28, 2026 · NCT04706663

Prostate Cancer Risk Identification in a Multi-Ethnic Cohort: a Prospective US-based Multi-center Validation Study of Proclarix

  • Om Research, San Diego
RecruitingObservational study
Ages 40 to 75 · Men · Updated Sep 28, 2026 · NCT07543757

DESTINY-PANTUMOUR04

  • Research Site, San Diego
RecruitingObservational study
Ages 18 to 130 · All sexes · Updated Sep 25, 2026 · NCT07124000

Study of AZD0516 as Monotherapy and in Combination in Participants With Metastatic Prostate Cancer

  • Research Site, Los Angeles
RecruitingPhase 1/2
Ages 18 to 130 · Men · Updated Sep 25, 2026 · NCT07181161

Phase 1 Study of ACE-232 to Treat Patients With Metastatic Castration-Resistant Prostate Cancer

  • University of California San Diego, Moores Cancer Center, La Jolla
RecruitingPhase 1
Ages 18 and older · Men · Updated Sep 25, 2026 · NCT06801236

A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)

  • CHAO Family Comprehensive Cancer Center and Ambulatory Care ( Site 0120), Irvine
  • UCLA Hematology/Oncology - Santa Monica ( Site 0044), Los Angeles
  • University of California, Irvine (UCI) Health - UC Irvine Medical Center ( Site 0040), Orange
  • and 4 more
RecruitingPhase 3
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06136650

This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve.

  • UCLA Hematology/Oncology - Alhambra, Alhambra
  • UCLA Hematology/Oncology - Atascadero, Atascadero
  • Cedars-Sinai Cancer Beverly Hills (drug treatment and dispensing location), Beverly Hills
  • and 20 more
RecruitingPhase 3
Ages 18 and older · Men · Updated Sep 24, 2026 · NCT07028853

A Study in Patients With Metastatic Castration-Resistant Prostate Cancer

  • START Los Angeles, Los Angeles
RecruitingPhase 1
Ages 18 and older · Men · Updated Sep 24, 2026 · NCT07719361

Open-label Study Comparing AAA817 Versus Standard of Care in the Treatment of Previously Treated PSMA-positive mCRPC Adults Who Have Disease Progressed on or After [177Lu]Lu-PSMA Targeted Therapy

  • VA Greater LA Healthcare System, Los Angeles
  • VA Palo Alto Health Care System, Palo Alto
  • Stanford University Medical Center, Palo Alto
  • and 2 more
RecruitingPhase 2/3
Ages 18 to 100 · Men · Updated Sep 22, 2026 · NCT06780670

A Study of LY4257496 in Participants With Cancer (OMNIRAY)

  • City of Hope, Duarte
  • University of California, Los Angeles (UCLA), Santa Monica
  • Stanford University Medical Center, Stanford
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07114601

A Study of Xaluritamig Plus Abiraterone Versus Investigator's Choice in Participants With Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer

  • City of Hope National Medical Center, Duarte
  • City of Hope Orange County Lennar Foundation Cancer Center, Duarte
  • Providence Saint Jude Medical Center, Fullerton
  • and 3 more
RecruitingPhase 3
Ages 18 and older · Men · Updated Sep 22, 2026 · NCT07213674

Study Comparing AAA817+ARPI Versus Standard of Care in Adult Participants With PSMA-positive mCRPC

  • Univ Cali Irvine ALS Neuromuscular, Orange
  • Stanford University Medical Center, Palo Alto
  • Sansum Clinic, Santa Barbara
RecruitingPhase 3
Ages 18 to 100 · Men · Updated Sep 22, 2026 · NCT06855277

A Study of Metastases Free Survival With Saruparib vs Placebo Added to a Standard RT/ADT in Men With High-risk Prostate Cancer With a BRCA Mutation

  • Research Site, La Jolla
  • Research Site, La Jolla
  • Research Site, Los Angeles
  • and 2 more
RecruitingPhase 3
Ages 18 and older · Men · Updated Sep 18, 2026 · NCT06952803

Carboplatin or Olaparib for BRcA Deficient Prostate Cancer

  • VA Greater Los Angeles Healthcare System, West Los Angeles, CA, West Los Angeles
RecruitingPhase 2
Ages 18 and older · Men · Updated Sep 17, 2026 · NCT04038502

A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)

  • City of Hope Comprehensive Cancer Center ( Site 0049), Duarte
  • City of Hope Lennar Foundation Cancer Center ( Site 0059), Irvine
  • Moores Cancer Center ( Site 0010), La Jolla
  • and 5 more
RecruitingPhase 3
Ages 18 and older · Men · Updated Sep 17, 2026 · NCT06925737

First-Time-in-Human Study of GSK5471713 in Adults With mCRPC

  • GSK Investigational Site, La Jolla
RecruitingPhase 1/2
Ages 18 and older · Men · Updated Sep 16, 2026 · NCT07332455

A Study of [225Ac]Ac-AKY-2519 in Patients With Metastatic Castration-Resistant Prostate Cancer

  • Hoag Memorial Hospital Presbyterian, Irvine
RecruitingPhase 1
Ages 18 and older · Men · Updated Sep 15, 2026 · NCT07581184

Sacral Neuromodulation for Male Overactive Bladder (MOAB)

  • USNC, Mountain View
  • Tri Valley Urology, Murrieta
  • University of California San Francisco, San Francisco
Recruiting
Ages 18 and older · Men · Updated Sep 14, 2026 · NCT06511141

Positron Emission Tomography Using 64Cu-SAR-bisPSMA in Participants With High-risk Prostate Cancer Prior to Radical Prostatectomy

  • Urology Group of Southern California, Los Angeles
  • Greater Los Angeles VA Medical Center, Los Angeles
  • UC Irvine Health, Orange
  • and 1 more
RecruitingPhase 3
Ages 18 and older · Men · Updated Sep 11, 2026 · NCT06056830

Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer

  • Kaiser Permanente-Deer Valley Medical Center, Antioch
  • Tower Cancer Research Foundation, Beverly Hills
  • Kaiser Permanente Dublin, Dublin
  • and 34 more
RecruitingPhase 3
Ages 18 and older · Men · Updated Sep 10, 2026 · NCT05946213

Safety, Pharmacokinetics, and Preliminary Efficacy of VIR-5500 (AMX-500) in Prostate Cancer

  • UCI Health Chao Family Comprehensive Cancer Center, Orange
  • Investigational Site Number: 403, Palo Alto
RecruitingPhase 1
Ages 18 and older · Men · Updated Sep 10, 2026 · NCT05997615

Pembrolizumab Plus 177Lu-PSMA-617 in Patients With Castration Resistant Prostate Cancer

  • University of California, San Francisco, San Francisco
RecruitingPhase 2
Ages 18 and older · Men · Updated Sep 10, 2026 · NCT05766371

Daily Adaptive Radiation Therapy Using an Individualized Approach for Prostate Cancer

  • Duarte Cancer Center, Duarte
  • City of Hope Orange County Lennar Foundation Cancer Center, Irvine
Recruiting
Ages 18 and older · Men · Updated Sep 9, 2026 · NCT05804318

A Study to Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors

  • USC/Norris Comprehensive Cancer Center, Los Angeles
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT06440005

Longitudinal Advanced Prostate Cancer Cohort (LAPCC)

  • Los Angeles General Medical Center, Los Angeles
  • USC / Norris Comprehensive Cancer Center, Los Angeles
RecruitingObservational study
Ages 18 and older · Men · Updated Sep 8, 2026 · NCT06067295

Study of JANX014 in Subjects With Metastatic Castration-Resistant Prostate Cancer

  • UC San Diego Moores Cancer Center, La Jolla
RecruitingPhase 1
Ages 18 and older · Men · Updated Sep 3, 2026 · NCT07545811

A Phase 2 Study to Evaluate the Effects of ASP5541 in Participants With Prostate Cancer

  • Sharp HealthCare - Sharp Memorial Hospital, San Diego
RecruitingPhase 2
Ages 18 and older · Men · Updated Sep 3, 2026 · NCT07005154

Prostate Active Surveillance Study

  • Veterans Affairs San Francisco Health Care System, San Francisco
  • University of California, San Francisco, San Francisco
  • Stanford University, Stanford
RecruitingObservational study
Ages 21 and older · Men · Updated Sep 2, 2026 · NCT00756665

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.