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Prostate Cancer clinical trials in Irvine, CA

14 studies for Prostate Cancer are looking for participants at sites in and around Irvine (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

A Study of Opevesostat (MK-5684) Versus Alternative Next-generation Hormonal Agent (NHA) in Metastatic Castration-resistant Prostate Cancer (mCRPC) Post One NHA (MK-5684-004)

RecruitingPhase 3
  • CHAO Family Comprehensive Cancer Center and Ambulatory Care ( Site 0120), Irvine
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06136650

A Clinical Study of Ifinatamab Deruxtecan (I-DXd) in People With Metastatic Prostate Cancer (MK-2400-001)

RecruitingPhase 3
  • City of Hope Lennar Foundation Cancer Center ( Site 0059), Irvine
Ages 18 and older · Men · Updated Sep 17, 2026 · NCT06925737

A Study of [225Ac]Ac-AKY-2519 in Patients With Metastatic Castration-Resistant Prostate Cancer

RecruitingPhase 1
  • Hoag Memorial Hospital Presbyterian, Irvine
Ages 18 and older · Men · Updated Sep 15, 2026 · NCT07581184

Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer

RecruitingPhase 3
  • UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine
Ages 18 and older · Men · Updated Sep 10, 2026 · NCT05946213

Daily Adaptive Radiation Therapy Using an Individualized Approach for Prostate Cancer

Recruiting
  • City of Hope Orange County Lennar Foundation Cancer Center, Irvine
Ages 18 and older · Men · Updated Sep 9, 2026 · NCT05804318

Testing Different Dosing Schedules of the Anti-cancer Drug, Lutetium 177Lu PSMA RLT and Its Effect on Patients With Advanced Prostate Cancer, RECIPROCAL Trial

RecruitingPhase 3
  • UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine
  • City of Hope at Irvine Lennar, Irvine
Ages 18 and older · Men · Updated Sep 2, 2026 · NCT07200830

Targeted Treatment for Metastatic Prostate Cancer, The PREDICT Trial

RecruitingPhase 2
  • UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine
Ages 18 and older · All sexes · Updated Sep 2, 2026 · NCT06632977

Testing the Effects of Exercise on Colorectal Cancer Development After Treatment With Pelvic Radiation Therapy for Prostate Cancer

Recruiting
  • City of Hope at Irvine Lennar, Irvine
Ages 40 to 80 · Men · Updated Aug 28, 2026 · NCT07790718

AZD2265 Compared With Standard of Care in PSMA-positive Metastatic Castration-resistant Prostate Cancer (VECTRA-01)

RecruitingPhase 3
  • Research Site, Irvine
Ages 18 and older · Men · Updated Aug 26, 2026 · NCT07611110

Docetaxel to Androgen Receptor Pathway Inhibitors in Patients With Metastatic Castration Sensitive Prostate Cancer and Suboptimal PSA Response

RecruitingPhase 3
  • UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine
  • City of Hope at Irvine Lennar, Irvine
  • Kaiser Permanente-Irvine, Irvine
Ages 18 and older · Men · Updated Jul 14, 2026 · NCT06592924

Carboplatin Chemotherapy Before Surgery for People With High-Risk Prostate Cancer and an Inherited BRCA1 or BRCA2 Gene Mutation

RecruitingPhase 2
  • City of Hope at Irvine Lennar, Irvine
Ages 18 and older · Men · Updated Jan 29, 2026 · NCT05806515

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Irvine
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

PyL in Patients With High Risk and Biochemically Recurrent Prostate Cancer

RecruitingPhase 2
  • Hoag Memorial Hospital Presbyterian, Irvine
Ages 18 and older · Men · Updated Jul 27, 2021 · NCT04700332

About Prostate Cancer

Prostate cancer is one of the most common types of cancer among American men. The risk goes up as men age. Learn about symptoms, tests, and treatment.

More about Prostate Cancer on MedlinePlus

Prostate Cancer trials in other cities

Other studies in Irvine

From ClinicalTrials.gov, data retrieved Oct 1, 2026. Each study sets its own eligibility; the study team decides who can join.