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Sickle Cell Disease clinical trials in Pennsylvania
20 studies for Sickle Cell Disease are looking for participants at sites in Pennsylvania.
Cities in Pennsylvania
A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE)
- Spoknwrdclinicaltrials, Easton
- Thomas Jefferson University Me, Philadelphia
RecruitingPhase 3
Ages 12 to 100 · All sexes · Updated Sep 28, 2026 · NCT06439082A Phase 1b, Open-Label Study of DISC-3405 in Participants With Sickle Cell Disease (SCD)
- University of Pittsburgh Medical Center (UPMC), Pittsburgh
RecruitingPhase 1
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07187973A Study to Evaluate How Well Etavopivat Works in People With Sickle Cell Disease
- Children's Hosptl Philadelphia, Philadelphia
- St Christopher Hosp for Child, Philadelphia
RecruitingPhase 3
Ages 12 and older · All sexes · Updated Sep 17, 2026 · NCT06612268A Phase I/II Study of ITU512 in Healthy Participants and Patients With Sickle Cell Disease
- Childrens Hospital Of Philadelphia, Philadelphia
RecruitingPhase 1/2Healthy volunteers welcome
Ages 12 to 55 · All sexes · Updated Sep 9, 2026 · NCT06546670A Study to Evaluate BMS-986470 in Healthy Volunteers and Participants With Sickle Cell Disease
- Local Institution - 0029, Philadelphia
- Thomas Jefferson University - Medicine/GI and Hepatology, Philadelphia
- Local Institution - 0032, Pittsburgh
RecruitingPhase 1/2Healthy volunteers welcome
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT06481306ATHN Transcends: A Natural History Study of Non-Neoplastic Hematologic Disorders
- Children's Hospital of Philadelphia, Philadelphia
- Penn Comprehensive Hemophilia and Thrombophilia Program/Hospital of the University of Pennsylvania, Philadelphia
- St. Christopher's Hospital for Children, Philadelphia
- and 1 more
RecruitingObservational study
All ages · All sexes · Updated Aug 17, 2026 · NCT04398628Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive Crisis
- University of Pittsburgh, Pittsburgh
- Hillman Cancer Center, Pittsburgh
RecruitingPhase 2
Ages 12 and older · All sexes · Updated Aug 14, 2026 · NCT06699849T-Cell Depleted Alternative Donor Bone Marrow Transplant for Sickle Cell Disease (SCD) and Other Anemias
- Children's Hospital of Pittsburgh of UPMC, Pittsburgh
RecruitingPhase 1/2
Ages 5 to 40 · All sexes · Updated Aug 13, 2026 · NCT03653338Ruxolitinib-Enhanced Haplo HCT for Children and Young Adults With Sickle Cell Disease
- Children's Hospital of Philadelphia, Philadelphia
RecruitingPhase 1/2
Ages 12 to 45 · All sexes · Updated Jun 4, 2026 · NCT07252050Comparing the Effectiveness of Matched Related Donor Hematopoietic Stem Cell Transplantation to Disease Modifying Therapy in Pediatric Patients With Sickle Cell Disease
- Children's Hospital of Philadelphia (MRD-HCT), Philadelphia
RecruitingObservational study
Ages 3 to 20 · All sexes · Updated Jun 4, 2026 · NCT06941389Clinical and Biomarker Effects of Depot Medroxyprogesterone Acetate in Females With Sickle Cell Disease
- Children's Hospital of Philadelphia, Philadelphia
RecruitingPhase 4
Ages 18 to 50 · Women · Updated May 28, 2026 · NCT06665997A Socio-ecological Approach for Improving Self-management in Adolescents With SCD
- Children's Hospital of Philadelphia, Philadelphia
Recruiting
Ages 13 to 21 · All sexes · Updated May 11, 2026 · NCT06290401Zinc Supplementation in Sickle Cell Disease: A Precursor to the Think Zinc for Bones Trial
- Children's Hospital of Philadelphia, Philadelphia
- Thomas Jefferson University Hospital, Philadelphia
RecruitingPhase 2
Ages 15 to 40 · All sexes · Updated Mar 13, 2026 · NCT06260891Stress Management and Mindfulness Intervention for Patients With Sickle Cell Disease
- University of Pennsylvania, Philadelphia
Recruiting
Ages 18 and older · All sexes · Updated Feb 27, 2026 · NCT07316478A Long-term Follow-up Study in Patients Who Received BEAM-101
- Children's Hospital of Philadelphia, Philadelphia
RecruitingObservational study
Ages 14 to 37 · All sexes · Updated Jan 28, 2026 · NCT07373639Data Collection Study of Patients With Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT With RIC
- UPMC Children's Hospital of Pittsburgh, Pittsburgh
RecruitingObservational study
2 Months – 60 Years · All sexes · Updated Jan 13, 2026 · NCT04528355Peer Support for Adolescents and Emerging Adults With Sickle Cell Pain
- UPMC University of Pittsburgh Classical Hematology Adult Clinic, Pittsburgh
- UPMC Children's Hospital of Pittsburgh, Pittsburgh
Recruiting
Ages 16 to 30 · All sexes · Updated Jan 7, 2026 · NCT06374238Reduced Intensity Conditioning for Non-Malignant Disorders Undergoing UCBT, BMT or PBSCT
- UPMC Children's Hospital of Pittsburgh, Pittsburgh
RecruitingPhase 2
2 Months – 55 Years · All sexes · Updated Dec 15, 2025 · NCT01962415Cutaneous Hydration Assessment in SCD
- UPMC Sickle Cell Clinic, Pittsburgh
Recruiting
Ages 12 and older · All sexes · Updated Nov 12, 2025 · NCT05210114Recruitment and Engagement in Care to Impact Practice Enhancement (RECIPE) for Sickle Cell Disease
- University of Pennsylvania, Philadelphia
RecruitingObservational study
Ages 18 and older · All sexes · Updated Jun 22, 2025 · NCT06385886From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.