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Breast Cancer clinical trials in Madison, WI

22 studies for Breast Cancer are looking for participants at sites in and around Madison (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer

RecruitingPhase 3
  • University of Wisconsin Carbone Cancer Center- University Hospital, Madison
Ages 18 and older · All sexes · Updated Oct 5, 2026 · NCT06982521

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

RecruitingPhase 1/2
  • University of Wisconsin Carbone Cancer Center, Madison
Ages 12 and older · All sexes · Updated Oct 2, 2026 · NCT04585750

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
  • William S Middleton VA Medical Center, Madison
  • University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison
  • University of Wisconsin Carbone Cancer Center - University Hospital, Madison
Ages 40 to 75 · All sexes · Updated Oct 2, 2026 · NCT05334069

A Phase 2 Neoadjuvant Study of Zanidatamab in Combination With Chemotherapy in Participants With HER2-positive Breast Cancer

RecruitingPhase 2
  • University of Wisconsin, Madison
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT07102381

Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors

RecruitingPhase 1
  • Wisconsin Institute for Medical Research, Madison
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06625775

A Clinical Study of Patritumab Deruxtecan to Treat Breast Cancer (MK-1022-016)

RecruitingPhase 3
  • Circuit Clinical/SSM Health Dean Medical Group ( Site 0039), Madison
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07060807

A Study of Sacituzumab Tirumotecan (MK-2870) as a Single Agent and in Combination With Pembrolizumab (MK-3475) Versus Treatment of Physician's Choice in Participants With HR+/HER2- Unresectable Locally Advanced or Metastatic Breast Cancer (MK-2870-010)

RecruitingPhase 3
  • University Hospital and UW Health Clinics-Carbone Cancer Center ( Site 0040), Madison
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06312176

A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)

RecruitingPhase 3
  • University of Wisconsin-Madison ( Site 0024), Madison
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06966700

Signatera-Guided CDK4/6 Inhibitor Therapy in Breast Cancer

Recruiting
  • University of Wisconsin, Madison
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07214532

A Study of LY4337713 in Participants With FAP-Positive Solid Tumors

RecruitingPhase 1
  • University of Wisconsin - Carbone Cancer Center, Madison
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07213791

A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence

RecruitingPhase 3
  • University of Wisconsin Carbone Cancer Center- University Hospital, Madison
Ages 18 and older · All sexes · Updated Sep 15, 2026 · NCT06492616

Study of AMXT 1501 and DFMO in Combination With Standard Therapies in Advanced Solid Tumors

RecruitingPhase 1/2
  • University of Wisconsin-Madison Carbone Cancer Center, Madison
Ages 18 and older · All sexes · Updated Sep 4, 2026 · NCT07287917

Trial of Pre-operative Neratinib and Endocrine Therapy With Trastuzumab in ER-Positive, HER-2 Positive Breast Cancers

RecruitingPhase 2
  • University of Wisconsin, Madison
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT04886531

Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

RecruitingPhase 3
  • University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison
  • University of Wisconsin Carbone Cancer Center - University Hospital, Madison
Ages 18 to 60 · Women · Updated Sep 2, 2026 · NCT05879926

Study of 18F-FFNP Breast PET/MRI

RecruitingPhase 2
  • UW Carbone Cancer Center, Madison
Ages 18 and older · Women · Updated Aug 31, 2026 · NCT06086704

Biomarkers to Detect Endocrine Therapy Resistance

RecruitingPhase 2
  • UW Carbone Cancer Center, Madison
Ages 18 and older · All sexes · Updated Aug 25, 2026 · NCT06067503

Real-Time MRI-Guided 3-Fraction Accelerated Partial Breast Irradiation in Early Breast Cancer

RecruitingPhase 2
  • University of Wisconsin Carbone Cancer Center, Madison
Ages 40 and older · Women · Updated Jun 11, 2026 · NCT03936478

De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)

RecruitingPhase 3
  • University of Wisconsin Carbone Cancer Center - Eastpark Medical Center, Madison
  • University of Wisconsin Carbone Cancer Center - University Hospital, Madison
Ages 50 to 70 · All sexes · Updated Apr 23, 2026 · NCT04852887

Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics

RecruitingObservational study
  • University of Wisconsin Carbone Cancer Center - University Hospital, Madison
Ages 18 and older · All sexes · Updated Mar 17, 2026 · NCT06418204

Effect on Body Movement and Mental Skills in Patients Who Received Gadolinium-based Contrast Media for Magnetic Resonance Examination Multiple Times Within 5 Years

RecruitingPhase 4
  • University of Wisconsin, Madison
Ages 18 to 64 · All sexes · Updated Jan 22, 2026 · NCT04373564

About Breast Cancer

Breast cancer is a cancer that starts in the breast tissue, when cells change and grow out of control. These extra cells can form a mass called a tumor.

More about Breast Cancer on MedlinePlus

Breast Cancer trials in other cities

Other studies in Madison

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.