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Non-Small Cell Lung Cancer clinical trials in Louisville, KY

22 studies for Non-Small Cell Lung Cancer are looking for participants at sites in and around Louisville (within about 30 miles). Open a study to see who can join and how to contact the study team.

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A Study of ZW251 in Participants With Advanced Solid Tumors

RecruitingPhase 1
  • Norton Cancer Institute, Louisville
Ages 18 and older · All sexes · Updated Oct 5, 2026 · NCT07164313

Safety and Efficacy of OBX-115 in Advanced Solid Tumors

RecruitingPhase 1/2
  • James Graham Brown Cancer Center (Melanoma/NSCLC), Louisville
Ages 18 and older · All sexes · Updated Oct 5, 2026 · NCT06060613

Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

RecruitingPhase 3
  • Baptist Health Louisville, Louisville
  • Baptist Health Floyd, New Albany · 4 mi away
Ages 18 and older · All sexes · Updated Oct 5, 2026 · NCT04267848

A Study to Learn About the Study Medicine Called PF-08046054/SGN-PDL1V Versus Docetaxel in Adult Participants With Previously-Treated Programmed Cell Death Ligand 1 (PD-L1) Positive Non-Small-Cell Lung Cancer (NSCLC)

RecruitingPhase 3
  • Norton Cancer Institute Downtown, Louisville
  • Norton Cancer Institute, Downtown, Louisville
  • Norton Hospital, Louisville
  • and 4 more
Ages 18 and older · All sexes · Updated Sep 28, 2026 · NCT07144280

Pan-tumor MRD Study

RecruitingObservational study
  • Baptist Health Louisville, Louisville
Ages 18 and older · All sexes · Updated Sep 24, 2026 · NCT06605404

A Study of Adagrasib Plus Pembrolizumab Plus Chemotherapy vs. Placebo Plus Pembrolizumab Plus Chemotherapy in Participants With Previously Untreated Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation (KRYSTAL-4)

RecruitingPhase 3
  • The University of Louisville, James Graham Brown Cancer Center, Louisville
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06875310

Evaluate BL-B01D1 in Patients With Metastatic or Unresectable Non-Small Cell Lung Cancer (NSCLC) and Other Solid Tumors

RecruitingPhase 1
  • Norton Cancer Institute, Louisville
Ages 18 and older · All sexes · Updated Sep 21, 2026 · NCT05983432

A Global Phase III Study of Rilvegostomig or Pembrolizumab Plus Chemotherapy for First-Line Treatment of Locally Advanced or Metastatic Squamous Non-small Cell Lung Cancer (NSCLC)

RecruitingPhase 3
  • Research Site, Louisville
  • Research Site, Louisville
Ages 18 and older · All sexes · Updated Sep 18, 2026 · NCT06692738

Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7

RecruitingPhase 2/3
  • University of Louisville, Louisville
  • Local Institution - 007-388-A, Louisville
Ages 18 and older · All sexes · Updated Sep 16, 2026 · NCT04613596

FiH Study to Investigate Safety, PK and Efficacy of the NaPi2b ADC TUB-040 in Patients With PROC or r/r Adenocarcinoma NSCLC

RecruitingPhase 1/2
  • Norton Cancer Institute Research, Louisville
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT06303505

Safety and Preliminary Effectiveness of BNT317, an Investigational Therapy for Advanced Solid Tumors

RecruitingPhase 1/2
  • Norton Cancer Institute PARENT, Louisville
Ages 18 and older · All sexes · Updated Sep 9, 2026 · NCT06750185

Study of INBRX-106 and INBRX-106 in Combination With Pembrolizumab (Keytruda®) in Subjects With Locally Advanced or Metastatic Solid Tumors (Hexavalent OX40 Agonist)

RecruitingPhase 1/2
  • Norton Cancer Institute, Louisville
Ages 18 and older · All sexes · Updated Jul 29, 2026 · NCT04198766

Clinical Trial Evaluating the Safety, Tolerability and Preliminary Efficacy of BNT116 Alone and in Combinations in Patients With Advanced Non-small Cell Lung Cancer

RecruitingPhase 1
  • Norton Cancer Institute, Louisville
Ages 18 and older · All sexes · Updated Jul 22, 2026 · NCT05142189

Autologous LN-145 in Patients With Metastatic Non-Small-Cell Lung Cancer

RecruitingPhase 2
  • University of Louisville, Louisville
Ages 18 to 70 · All sexes · Updated Jun 26, 2026 · NCT04614103

Study of PF-07248144 in Advanced or Metastatic Solid Tumors

RecruitingPhase 2
  • University Medical Center, lnc.:DBA University of Louisville Hospital, Louisville
  • University of Louisville, Louisville
  • UofL Health Brown Cancer Center, Louisville
Ages 18 and older · All sexes · Updated Apr 16, 2026 · NCT04606446

A Phase 1/2a Study of DB-1311/BNT324 in Advanced/Metastatic Solid Tumors

RecruitingPhase 1/2
  • Research Site 115, Louisville
Ages 18 and older · All sexes · Updated Nov 21, 2025 · NCT05914116

A Study of the Oral EGFR Inhibitor PLB1004 in Non-Small Cell Lung Cancer

RecruitingPhase 1
  • Research Site, Louisville
Ages 18 and older · All sexes · Updated Apr 23, 2025 · NCT06046495

The Effect of Beta-glucan in Non-Small Cell Lung Cancer

Recruiting
  • James Graham Brown Cancer Center, Louisville
Ages 18 and older · All sexes · Updated Jan 10, 2025 · NCT00682032

Non-Small Cell Lung Cancer trials in other cities

Other studies in Louisville

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.