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Head and Neck Squamous Cell Carcinoma clinical trials in Ann Arbor, MI

12 studies for Head and Neck Squamous Cell Carcinoma are looking for participants at sites in and around Ann Arbor (within about 30 miles). Open a study to see who can join and how to contact the study team.

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FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC

RecruitingPhase 2/3
  • University of Michigan (Site # 161), Ann Arbor
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06788990

Testing the Addition of Anti-Cancer Drug, Cetuximab, to Standard of Care Treatment (Pembrolizumab) for Returning or Spreading Head and Neck Cancer After Previous Treatment

RecruitingPhase 3
  • Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor
  • Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus, Ypsilanti · 7 mi away
  • Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital, Chelsea · 15 mi away
  • and 1 more
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06589804

A Study of Amivantamab in Addition to Standard of Care Agents (SOC) Compared With SOC Alone in Participants With Recurrent/Metastatic Head and Neck Cancer

RecruitingPhase 3
  • Trinity Health St Joseph Mercy Ann Arbor, Ann Arbor
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07276399

A Study of Amivantamab Alone or in Addition to Other Treatment Agents in Participants With Head and Neck Cancer

RecruitingPhase 1/2
  • University of Michigan Rogel Cancer Center, Ann Arbor
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06385080

BiCaZO: A Study Combining Two Immunotherapies (Cabozantinib and Nivolumab) to Treat Patients With Advanced Melanoma or Squamous Cell Head and Neck Cancer, an immunoMATCH Pilot Study

RecruitingPhase 2
  • Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor
  • University of Michigan Rogel Cancer Center, Ann Arbor
  • Huron Gastroenterology PC, Ypsilanti · 7 mi away
  • and 5 more
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT05136196

Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery

RecruitingPhase 2
  • Trinity Health Saint Joseph Mercy Hospital Ann Arbor, Ann Arbor
  • University of Michigan Rogel Cancer Center, Ann Arbor
  • Huron Gastroenterology PC, Ypsilanti · 7 mi away
  • and 6 more
Ages 18 and older · All sexes · Updated Sep 14, 2026 · NCT02734537

Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity Cancer

RecruitingPhase 2/3
  • University of Michigan Rogel Cancer Center, Ann Arbor
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT04333537

Personalized Neck Radiation Therapy Directed by Sentinel Lymph Node Biopsy for the Treatment of Oral Cavity Squamous Cell Carcinoma, PRECEDENT Trial

RecruitingPhase 2
  • University of Michigan Comprehensive Cancer Center, Ann Arbor
Ages 18 and older · All sexes · Updated Jul 31, 2026 · NCT07121595

Study With ABBV-CLS-484 in Participants With Locally Advanced or Metastatic Tumors

RecruitingPhase 1
  • University of Michigan Comprehensive Cancer Center Michigan Medicine /ID# 252010, Ann Arbor
Ages 18 and older · All sexes · Updated Jun 4, 2026 · NCT04777994

A Phase II Study for p16+ Oropharyngeal Cancer PerSonalized De-escalation Treatment at University of MIchigan (CuSToMIze)

RecruitingPhase 2
  • University of Michigan Rogel Cancer Center, Ann Arbor
Ages 18 and older · All sexes · Updated Feb 2, 2026 · NCT05894083

A Phase I/II Study of VLS-1488 in Subjects With Advanced Cancer

RecruitingPhase 1/2
  • University of Michigan, Ann Arbor
Ages 18 and older · All sexes · Updated Nov 4, 2025 · NCT05902988

A Study to Evaluate TROP2 ADC LCB84 Single Agent and in Combination With an Anti-PD-1 Ab in Advanced Solid Tumors

RecruitingPhase 1/2
  • University of Michigan, Ann Arbor
Ages 18 and older · All sexes · Updated Sep 24, 2025 · NCT05941507

Head and Neck Squamous Cell Carcinoma trials in other cities

Other studies in Ann Arbor

From ClinicalTrials.gov, data retrieved Oct 6, 2026. Each study sets its own eligibility; the study team decides who can join.