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Lung Cancer clinical trials in Indianapolis, IN

16 studies for Lung Cancer are looking for participants at sites in and around Indianapolis (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

RecruitingPhase 3
  • Saint Catherine Hospital, Indianapolis
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT04267848

Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trial

RecruitingPhase 3
  • Saint Catherine Hospital, Indianapolis
Ages 70 and older · All sexes · Updated Oct 1, 2026 · NCT06096844

Osimertinib With or Without Bevacizumab as Initial Treatment for Patients With EGFR-Mutant Lung Cancer

RecruitingPhase 3
  • Saint Catherine Hospital, Indianapolis
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT04181060

Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors

RecruitingPhase 1
  • Indiana University Simon Comprehensive Cancer Center, Indianapolis
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06625775

Immunotherapy After Surgery for People Who Have No Remaining Cancer Cells After Standard Treatment for Early-Stage Non-Small Cell Lung Cancer, INSIGHT Trial

RecruitingPhase 3
  • Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis
  • Sidney and Lois Eskenazi Hospital, Indianapolis
  • IU Health West Hospital, Avon · 13 mi away
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06498635

Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

RecruitingPhase 3
  • Community Health Network, Inc, Indianapolis
  • Community Health Network, Inc., Indianapolis
  • Community Health Network, Inc., Indianapolis
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07222566

Safety, Efficacy, and Pharmacokinetics of BNT327 in Combination With Chemotherapy and Other Investigational Agents for Lung Cancer

RecruitingPhase 2/3
  • Indiana University Health University Hospital, Indianapolis
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06712316

Study of Elironrasib and Daraxonrasib as Monotherapies and Combination Therapy in Participants With Advanced KRAS G12C Mutant Solid Tumors

RecruitingPhase 1/2
  • Community Health Network, Indianapolis
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT06128551

Increasing Equity in Lung Cancer Screening

RecruitingHealthy volunteers welcome
  • Eskenazi Health, Indianapolis
Ages 50 to 80 · All sexes · Updated Sep 10, 2026 · NCT06360822

A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

RecruitingPhase 3
  • Indiana University Melvin and Bren Simon Cancer Center, Indianapolis
  • Franciscan Health, Indianapolis
  • Community Cancer Center North, Indianapolis
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT06119581

Rapid Autopsy Protocol for Patients With Small Cell Lung Cancer

RecruitingObservational study
  • Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis
  • Roudebush VA Medical Center, Indianapolis
  • Sidney and Lois Eskenazi Hospital, Indianapolis
Ages 18 and older · All sexes · Updated Jul 14, 2026 · NCT05889546

Study to Evaluate the Safety, Tolerability & Efficacy of TNG462 in Combination in PDAC & NSCLC Patients

RecruitingPhase 1/2
  • University of Indiana, Indianapolis
Ages 18 and older · All sexes · Updated May 14, 2026 · NCT06922591

Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has a MET Exon 14 Skipping Gene Change (An Expanded Lung-MAP Treatment Trial)

RecruitingPhase 2
  • Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis
18 Minutes · All sexes · Updated May 5, 2026 · NCT06031688

Adding the Immunotherapy Drug Cemiplimab to Usual Treatment for People With Advanced Non-Small Cell Lung Cancer Who Had Previous Treatment With Platinum Chemotherapy and Immunotherapy (An Expanded Lung-MAP Treatment Trial)

RecruitingPhase 2/3
  • Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis
  • Richard L. Roudebush Veterans Affairs Medical Center, Indianapolis
Ages 18 and older · All sexes · Updated May 5, 2026 · NCT06616584

Temozolomide and Atezolizumab for Subsequent Line for the Treatment of Metastatic or Recurrent Small Cell Lung Cancer

RecruitingPhase 2
  • Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis
Ages 18 and older · All sexes · Updated Apr 8, 2026 · NCT04919382

Veterans Affairs Lung Cancer Surgery Or Stereotactic Radiotherapy

Recruiting
  • Richard L. Roudebush VA Medical Center, Indianapolis, IN, Indianapolis
Ages 18 and older · All sexes · Updated Feb 19, 2026 · NCT02984761

About Lung Cancer

Lung cancer forms in tissues of the lung, usually in the cells that line the air passages. It is the leading cause of cancer death in both men and women.

More about Lung Cancer on MedlinePlus

Lung Cancer trials in other cities

Other studies in Indianapolis

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.