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Breast Cancer clinical trials in Indianapolis, IN

20 studies for Breast Cancer are looking for participants at sites in and around Indianapolis (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Phase IIIb Study of Ribociclib + ET in Early Breast Cancer

RecruitingPhase 3
  • Investigative Clinical R of Indiana, Indianapolis
Ages 18 to 100 · All sexes · Updated Oct 2, 2026 · NCT05827081

Open-Label Study of BBO-10203 in Subjects With Advanced Solid Tumors

RecruitingPhase 1
  • Indiana University Simon Comprehensive Cancer Center, Indianapolis
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06625775

Low Dose Aspirin for the Prevention of Postpartum Related Breast Cancer

RecruitingPhase 2Healthy volunteers welcome
  • Indiana University Simon Comprehensive Cancer Center, Indianapolis
Ages 18 to 45 · Women · Updated Oct 1, 2026 · NCT05557877

A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)

RecruitingPhase 3
  • Franciscan Health ( Site 0077), Indianapolis
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT06966700

Signatera-Guided CDK4/6 Inhibitor Therapy in Breast Cancer

Recruiting
  • Indiana University, Indianapolis
Ages 18 and older · All sexes · Updated Sep 23, 2026 · NCT07214532

A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

RecruitingPhase 3
  • Indiana University Health University Hospital, Indianapolis
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07174336

A Study of Imlunestrant (LY3484356) in Premenopausal Women With Estrogen Receptor-Positive (ER+) Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Early Breast Cancer

RecruitingPhase 2
  • Indiana University Melvin and Bren Simon Cancer Center, Indianapolis
Ages 18 and older · Women · Updated Sep 22, 2026 · NCT07287098

A Study of LY4337713 in Participants With FAP-Positive Solid Tumors

RecruitingPhase 1
  • Indiana University (IU) School of Medicine, Indianapolis
Ages 18 and older · All sexes · Updated Sep 22, 2026 · NCT07213791

Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer

RecruitingPhase 3
  • Community Health Network, Inc, Indianapolis
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT06982521

Toci +/- SOC Chemo for Metastatic Triple Negative and ER-positive, HER2-negative Breast Cancers

RecruitingPhase 2
  • Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis
  • Sidney and Lois Eskenazi Hospital, Indianapolis
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT05846789

Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

RecruitingPhase 3
  • Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis
  • Sidney and Lois Eskenazi Hospital, Indianapolis
  • Community Cancer Center East, Indianapolis
  • and 5 more
Ages 18 to 60 · Women · Updated Sep 2, 2026 · NCT05879926

HER2 Vaccine for Locally Advanced Breast Cancer

RecruitingPhase 1
  • Indiana University Melvin & Bren Simon Comprehensive Cancer Center, Indianapolis
Ages 18 and older · All sexes · Updated Aug 27, 2026 · NCT06949410

Exercise in Metastatic Breast Cancer: EMBody

Recruiting
  • Indiana University Melvin & Bren Simon Cancer Center, Indianapolis
Ages 18 and older · All sexes · Updated Apr 27, 2026 · NCT05468034

De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)

RecruitingPhase 3
  • Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis
  • Franciscan Health Indianapolis, Indianapolis
  • Franciscan Health Mooresville, Mooresville · 16 mi away
Ages 50 to 70 · All sexes · Updated Apr 23, 2026 · NCT04852887

Avelumab or Hydroxychloroquine With or Without Palbociclib to Eliminate Dormant Breast Cancer

RecruitingPhase 2
  • Indiana University, Indianapolis
Ages 18 and older · All sexes · Updated Apr 9, 2026 · NCT04841148

A Phase 1/2 Clinical Trial to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of HMBD-501 in Patients With HER3-Expressing Solid Tumors

RecruitingPhase 1/2
  • Research Site, Indianapolis
Ages 18 and older · All sexes · Updated Mar 2, 2026 · NCT06956690

NearWave Optical Molecular Monitoring

Recruiting
  • Indiana University Simon Comprehensive Cancer Center, Indianapolis
Ages 18 and older · Women · Updated Feb 17, 2026 · NCT06744465

S1501 Dual Observational and Randomized Cohort Study of Patients With Metastatic HER-2+ Breast Cancer at Risk of Cardiac Toxicity

RecruitingPhase 3
  • Franciscan Health Indianapolis, Indianapolis
  • Franciscan Health Mooresville, Mooresville · 16 mi away
Ages 18 and older · All sexes · Updated Oct 8, 2025 · NCT03418961

About Breast Cancer

Breast cancer is a cancer that starts in the breast tissue, when cells change and grow out of control. These extra cells can form a mass called a tumor.

More about Breast Cancer on MedlinePlus

Breast Cancer trials in other cities

Other studies in Indianapolis

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.