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Lung Cancer clinical trials in Baltimore, MD

40 studies for Lung Cancer are looking for participants at sites in and around Baltimore (within about 30 miles). Open a study to see who can join and how to contact the study team.

Recruiting for a study here? Feature it at the top of this page — $99 for 30 days →

Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

RecruitingPhase 3
  • Greater Baltimore Medical Center, Baltimore
  • Sinai Hospital of Baltimore, Baltimore
  • Kaiser Permanente-Woodlawn Medical Center, Baltimore
  • and 3 more
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT04267848

Substudy 01I: A Study of Investigational Agents in Participants With Previously Treated Stage IV Squamous Non-small Cell Lung Cancer (NSCLC) (MK-3475-01I/KEYMAKER-U01I)

RecruitingPhase 2
  • MedStar Franklin Square Medical Center ( Site 0033), Baltimore
Ages 18 and older · All sexes · Updated Oct 2, 2026 · NCT06780098

Collecting Blood Samples From Patients With and Without Cancer to Evaluate Tests for Early Cancer Detection

RecruitingObservational studyHealthy volunteers welcome
  • Mercy Medical Center, Baltimore
  • Sinai Hospital of Baltimore, Baltimore
  • MedStar Franklin Square Medical Center/Weinberg Cancer Institute, Baltimore
  • and 2 more
Ages 40 to 75 · All sexes · Updated Oct 2, 2026 · NCT05334069

A Study of HER3-DXd in Subjects With Locally Advanced or Metastatic Solid Tumors

RecruitingPhase 2
  • Johns Hopkins University, Baltimore
Ages 18 and older · All sexes · Updated Oct 1, 2026 · NCT06172478

Chemotherapy Combined With Immunotherapy Versus Immunotherapy Alone for Older Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trial

RecruitingPhase 3
  • University of Maryland/Greenebaum Cancer Center, Baltimore
  • Sinai Hospital of Baltimore, Baltimore
Ages 70 and older · All sexes · Updated Oct 1, 2026 · NCT06096844

Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301)

RecruitingPhase 3
  • Johns Hopkins University of Medicine, Baltimore
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT06881784

DK222 Study at Hopkins

RecruitingPhase 1
  • Johns Hopkins Hospital, Baltimore
Ages 18 and older · All sexes · Updated Sep 29, 2026 · NCT07140315

Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer

RecruitingPhase 3
  • Maryland Oncology Hematology, P.A., Annapolis · 22 mi away
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07222566

A Study to Investigate Ubamatamab With and Without Marlotamig (REGN7075) in Adult Participants With Advanced/Metastatic Non-Small Cell Lung Cancer (NSCLC)

RecruitingPhase 2
  • University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore
Ages 18 and older · All sexes · Updated Sep 25, 2026 · NCT07154290

Neoadjuvant and Adjuvant Treatment in Resectable Non-small Cell Lung Cancer

RecruitingPhase 2
  • Research Site, Baltimore
Ages 18 to 95 · All sexes · Updated Sep 23, 2026 · NCT05061550

Study of RMC-5127 in Patients With Advanced KRAS G12V-Mutant Solid Tumors

RecruitingPhase 1
  • Johns Hopkins, Baltimore
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT07349537

Testing the Combination of an Anti-cancer Drug, Iadademstat, With Other Anti-cancer Drugs (Atezolizumab or Durvalumab) at Improving Outcomes for Small Cell Lung Cancer

RecruitingPhase 1/2
  • University of Maryland/Greenebaum Cancer Center, Baltimore
  • Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore
Ages 18 and older · All sexes · Updated Sep 17, 2026 · NCT06287775

A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

RecruitingPhase 3
  • Johns Hopkins Bayview Medical Center, Baltimore
Ages 18 and older · All sexes · Updated Sep 8, 2026 · NCT06119581

Open-label Study of BBO-8520 in Adult Subjects With KRASG12C Non-small Cell Lung Cancer

RecruitingPhase 1
  • University of Maryland Marlene & Stewart Greenebaum Comprehensive Cancer Center, Baltimore
Ages 18 and older · All sexes · Updated Sep 3, 2026 · NCT06343402

A Study of Pembrolizumab With or Without Chemotherapy in Combination With Additional Treatments for Advanced Non-Small Cell Lung Cancer (NSCLC) (MK-3475-01G/KEYMAKER U01)

RecruitingPhase 2
  • MedStar Franklin Square Medical Center ( Site 0033), Baltimore
Ages 18 and older · All sexes · Updated Aug 18, 2026 · NCT06731907

Testing Proton Craniospinal Radiation Therapy Versus the Usual Radiation Therapy for Leptomeningeal Metastasis, RADIATE-LM Trial

RecruitingPhase 3
  • Johns Hopkins University/Sidney Kimmel Cancer Center, Baltimore
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT06500481

Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-Small Cell Lung Cancer

RecruitingPhase 3
  • Greater Baltimore Medical Center, Baltimore
  • Sinai Hospital of Baltimore, Baltimore
Ages 18 and older · All sexes · Updated Aug 17, 2026 · NCT05624996

Immunobiology Blood and Tissue Collection of Upper Aerodigestive Malignancies

RecruitingObservational study
  • Johns Hopkins University, Baltimore
Ages 18 and older · All sexes · Updated Aug 6, 2026 · NCT05995821

Signature Development and Validation Protocol for an Epigenetic Assay in Diagnosing Lung Cancer

RecruitingObservational studyHealthy volunteers welcome
  • University of Maryland Baltimore Washington Medical Center, Glen Burnie · 9 mi away
Ages 18 and older · All sexes · Updated Jul 29, 2026 · NCT07008664

A Study of Peluntamig (PT217) in Patients With Neuroendocrine Carcinomas Expressing DLL3 (the SKYBRIDGE Study)

RecruitingPhase 1/2
  • Sidney Kimmel Comprehensive Cancer Center at John Hopkins, Baltimore
Ages 18 and older · All sexes · Updated Jul 15, 2026 · NCT05652686

EXoPERT EMERALD Clinical Study

RecruitingObservational studyHealthy volunteers welcome
  • John Hopkins University, Baltimore
Ages 45 and older · All sexes · Updated Jul 1, 2026 · NCT07186296

GCC 2546- Motion Management

Recruiting
  • University of Maryland Greenebaum Cancer Center, Baltimore
Ages 18 and older · All sexes · Updated Jun 26, 2026 · NCT07398209

Comparing Combinations of Targeted Drugs for Advanced Non-Small Cell Lung Cancer That Has EGFR and MET Gene Changes (A Lung-MAP Treatment Trial)

RecruitingPhase 2
  • Kaiser Permanente-Woodlawn Medical Center, Baltimore
  • Kaiser Permanente Lutherville - Timonium Medical Center, Lutherville · 9 mi away
Ages 18 and older · All sexes · Updated Jun 3, 2026 · NCT05642572

Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors

RecruitingPhase 1
  • Johns Hopkins University, Baltimore
Ages 18 and older · All sexes · Updated Jun 3, 2026 · NCT06040541

A Study to Evaluate the Safety, Tolerability, and Efficacy of BMS-986523 Alone and in Combination With Anti-Cancer Agents in Participants With Advanced Solid Malignancies

RecruitingPhase 1/2
  • Johns Hopkins Hospital, Baltimore
Ages 18 and older · All sexes · Updated May 28, 2026 · NCT07223047

Study of RMC-6236 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS

RecruitingPhase 1/2
  • Johns Hopkins University, Baltimore
Ages 18 and older · All sexes · Updated May 15, 2026 · NCT05379985

Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has a MET Exon 14 Skipping Gene Change (An Expanded Lung-MAP Treatment Trial)

RecruitingPhase 2
  • Kaiser Permanente-Woodlawn Medical Center, Baltimore
  • Kaiser Permanente Lutherville - Timonium Medical Center, Lutherville · 9 mi away
18 Minutes · All sexes · Updated May 5, 2026 · NCT06031688

Adding the Immunotherapy Drug Cemiplimab to Usual Treatment for People With Advanced Non-Small Cell Lung Cancer Who Had Previous Treatment With Platinum Chemotherapy and Immunotherapy (An Expanded Lung-MAP Treatment Trial)

RecruitingPhase 2/3
  • Saint Agnes Hospital, Baltimore
  • Kaiser Permanente-Woodlawn Medical Center, Baltimore
  • Kaiser Permanente Lutherville - Timonium Medical Center, Lutherville · 9 mi away
Ages 18 and older · All sexes · Updated May 5, 2026 · NCT06616584

Study to Evaluate Sutetinib Maleate Capsule in Locally Advanced or Metastatic Non-small Cell Lung Cancer

RecruitingPhase 2
  • University of Maryland Medical Center, Baltimore
Ages 18 and older · All sexes · Updated Apr 28, 2026 · NCT05168566

A Phase 1/2 Study of VS-7375 in Patients With KRAS G12D-Mutated Solid Tumors

RecruitingPhase 1/2
  • Johns Hopkins University, Baltimore
Ages 18 and older · All sexes · Updated Apr 22, 2026 · NCT07020221

Durvalumab and Tremelimumab in Combination With Chemotherapy in HIV-infected Patients With Non-small Cell Lung Cancer

RecruitingPhase 2
  • Marlene and Stewart Greenebaum Comprehensive Cancer Center, Baltimore
  • Harry and Jeannette Weinberg Cancer Institute at Franklin Square, Baltimore
Ages 18 and older · All sexes · Updated Mar 16, 2026 · NCT04499053

Veterans Affairs Lung Cancer Surgery Or Stereotactic Radiotherapy

Recruiting
  • Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD, Baltimore
Ages 18 and older · All sexes · Updated Feb 19, 2026 · NCT02984761

A Study of CLSP-1025 in Adult Patients With Solid Tumors That Harbor the p53 R175H Mutation

RecruitingPhase 1
  • Johns Hopkins - Sidney Kimmel Comprehensive Cancer Center, Baltimore
Ages 18 and older · All sexes · Updated Feb 13, 2026 · NCT06778863

Study of PLK1 Inhibitor, Onvansertib, in Relapsed Small Cell Lung Cancer

RecruitingPhase 2
  • University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore
Ages 18 and older · All sexes · Updated Dec 17, 2025 · NCT05450965

Full-Field Optical Coherence Tomography (FFOCT) for Evaluation of Bronchoscopic Small Biopsy Specimens

RecruitingObservational study
  • Johns Hopkins Hospital, Baltimore
Ages 18 and older · All sexes · Updated Dec 17, 2025 · NCT05171478

SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry

RecruitingObservational study
  • Massive Bio SYNERGY-AI site, Baltimore
  • Massive Bio SYNERGY-AI site, Towson · 8 mi away
All ages · All sexes · Updated Oct 28, 2025 · NCT03452774

Clinical Validation of Freenome Multiomics Blood Test for Lung Cancer Screening

RecruitingObservational study
  • Ascension St. Agnes Hospital, Baltimore
Ages 50 and older · All sexes · Updated Aug 5, 2025 · NCT06122077

Clinical Utility of Management of Patients With Pulmonary Nodules Using the Percepta Nasal Swab Classifier

RecruitingObservational study
  • University of Maryland Medical Center, Baltimore
Ages 29 to 85 · All sexes · Updated Nov 13, 2024 · NCT06426628

First in Human Phase 1 Study of AG01 Anti-Progranulin/GP88 Antibody in Advanced Solid Tumor Malignancies

RecruitingPhase 1
  • University of Maryland Greenebaum Comprehensive Cancer Center, Baltimore
Ages 18 and older · All sexes · Updated Nov 28, 2022 · NCT05627960

About Lung Cancer

Lung cancer forms in tissues of the lung, usually in the cells that line the air passages. It is the leading cause of cancer death in both men and women.

More about Lung Cancer on MedlinePlus

Lung Cancer trials in other cities

Other studies in Baltimore

From ClinicalTrials.gov, data retrieved Oct 5, 2026. Each study sets its own eligibility; the study team decides who can join.